Knowledge-Based Approaches to Off-Target Screening

Selective binding of a drug for its target vs other proteins is an important consideration in designing compounds with minimal risk of toxicity and therefore a key aspect of lead optimization. Screening all compounds against all known off-target proteins would be prohibitively expensive, so project...

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Veröffentlicht in:	Methods in enzymology 2018, Vol.610, p.311-323
1. Verfasser:	McMasters, Daniel R
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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