Non-coding RNA Neat1 and Abhd11os expressions are dysregulated in medium spiny neurons of Huntington disease model mice

•The expression of many ncRNAs was dysregulated in R6/2 HD model mouse brains.•Abhd11os, Neat1-1 and Neat1-2 expressions were downregulated in R6/2.•ViewRNA ISH provided precise detection of ncRNAs with low expression levels. Huntington Disease (HD) is a neurodegenerative disorder caused by expanded...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Neuroscience research 2019-10, Vol.147, p.58-63
Hauptverfasser:	Park, Hongsun, Miyazaki, Haruko, Yamanaka, Tomoyuki, Nukina, Nobuyuki
Format:	Artikel
Sprache:	eng
Schlagworte:	Abhd11os Animals Brain - metabolism Corpus Striatum - metabolism Disease Models, Animal Dopamine and cAMP-Regulated Phosphoprotein 32 - metabolism Gene Expression Humans Huntington disease Huntington Disease - genetics Huntington Disease - metabolism Huntington Disease - pathology In Situ Hybridization Mice Mice, Transgenic Microarray Neat1 Neurons - metabolism Neurons - pathology Non-coding RNA RNA, Long Noncoding - biosynthesis RNA, Long Noncoding - genetics RNA, Long Noncoding - metabolism Serine Proteases - biosynthesis Serine Proteases - genetics Serine Proteases - metabolism Transcriptome ViewRNA in situ hybridization
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!