ADAR RNA editing in innate immune response phasing, in circadian clocks and in sleep

Adenosine deaminases acting on RNA (ADARs) convert adenosine to inosine in dsRNA. ADAR editing in pre-mRNAs recodes open reading frames and alters splicing, mRNA structure and interactions with miRNAs. Here, we review ADAR gene expression, splice forms, posttranslational modifications, subcellular l...

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Veröffentlicht in:	Biochimica et biophysica acta. Gene regulatory mechanisms 2019-03, Vol.1862 (3), p.356-369
Hauptverfasser:	Sinigaglia, Ketty, Wiatrek, Dagmara, Khan, Anzer, Michalik, David, Sambrani, Nagraj, Sedmík, Jiří, Vukić, Dragana, O'Connell, Mary A., Keegan, Liam P.
Format:	Artikel
Sprache:	eng
Schlagworte:	ADAR Adenosine Deaminase - genetics Adenosine Deaminase - metabolism Animals Circadian Clocks Circadian rhythm dsRNA Epitranscriptome Humans Immunity, Innate Innate immunity microRNA RNA Editing Sleep
Online-Zugang:	Volltext
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