Effects of Transcranial Direct Current Stimulation on Episodic Memory in Amnestic Mild Cognitive Impairment: A Pilot Study
Abstract Objectives Episodic memory is impaired in amnestic mild cognitive impairment (aMCI), which is posited as a potential prodromal form of Alzheimer’s disease. Reactivated existing memories become sensitive to modification during reconsolidation. There is evidence that the lateral prefrontal co...
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| Veröffentlicht in: | The journals of gerontology. Series B, Psychological sciences and social sciences Psychological sciences and social sciences, 2020-08, Vol.75 (7), p.1403-1413 |
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| container_title | The journals of gerontology. Series B, Psychological sciences and social sciences |
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| creator | Manenti, Rosa Sandrini, Marco Gobbi, Elena Binetti, Giuliano Cotelli, Maria |
| description | Abstract
Objectives
Episodic memory is impaired in amnestic mild cognitive impairment (aMCI), which is posited as a potential prodromal form of Alzheimer’s disease. Reactivated existing memories become sensitive to modification during reconsolidation. There is evidence that the lateral prefrontal cortex (PFC) plays causal role in episodic memory reconsolidation. Transcranial direct current stimulation (tDCS) applied to the PFC after a contextual reminder enhanced episodic memory performance up to 1 month, conceivably through reconsolidation, in older adults with subjective memory complaints, a condition that may represent a “pre-mild cognitive impairment” stage. The aim of this pilot study was to test the effect of PFC-tDCS (anode over left lateral PFC, cathode over right supraorbital area) after a contextual reminder on episodic memory in older adults with aMCI.
Method
Older adults with aMCI learned a list of words. Twenty-four hours later, tDCS (Active or Sham) was applied after a contextual reminder. Memory retrieval (free recall and recognition) was tested 48 hrs and 1 month after the learning session.
Results
Active tDCS enhanced recognition memory relative to Sham stimulation.
Discussion
Modulating reconsolidation with PFC-tDCS might be a novel intervention to enhance episodic memories in aMCI. |
| doi_str_mv | 10.1093/geronb/gby134 |
| format | Article |
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Objectives
Episodic memory is impaired in amnestic mild cognitive impairment (aMCI), which is posited as a potential prodromal form of Alzheimer’s disease. Reactivated existing memories become sensitive to modification during reconsolidation. There is evidence that the lateral prefrontal cortex (PFC) plays causal role in episodic memory reconsolidation. Transcranial direct current stimulation (tDCS) applied to the PFC after a contextual reminder enhanced episodic memory performance up to 1 month, conceivably through reconsolidation, in older adults with subjective memory complaints, a condition that may represent a “pre-mild cognitive impairment” stage. The aim of this pilot study was to test the effect of PFC-tDCS (anode over left lateral PFC, cathode over right supraorbital area) after a contextual reminder on episodic memory in older adults with aMCI.
Method
Older adults with aMCI learned a list of words. Twenty-four hours later, tDCS (Active or Sham) was applied after a contextual reminder. Memory retrieval (free recall and recognition) was tested 48 hrs and 1 month after the learning session.
Results
Active tDCS enhanced recognition memory relative to Sham stimulation.
Discussion
Modulating reconsolidation with PFC-tDCS might be a novel intervention to enhance episodic memories in aMCI.</description><identifier>ISSN: 1079-5014</identifier><identifier>EISSN: 1758-5368</identifier><identifier>DOI: 10.1093/geronb/gby134</identifier><identifier>PMID: 30395314</identifier><language>eng</language><publisher>US: Oxford University Press</publisher><subject>Aged ; Cognitive Dysfunction - psychology ; Cognitive Dysfunction - therapy ; Double-Blind Method ; Female ; Humans ; Male ; Memory and Learning Tests ; Memory, Episodic ; Mental Recall ; Neuropsychological Tests ; Pilot Projects ; Transcranial Direct Current Stimulation - methods</subject><ispartof>The journals of gerontology. Series B, Psychological sciences and social sciences, 2020-08, Vol.75 (7), p.1403-1413</ispartof><rights>The Author(s) 2018. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com. 2018</rights><rights>The Author(s) 2018. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c431t-45b71fc80980e93b537adc57b4df93b37808b45cfc0f8e38d56017f1cabfc44c3</citedby><cites>FETCH-LOGICAL-c431t-45b71fc80980e93b537adc57b4df93b37808b45cfc0f8e38d56017f1cabfc44c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1578,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30395314$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Anderson, Nicole</contributor><creatorcontrib>Manenti, Rosa</creatorcontrib><creatorcontrib>Sandrini, Marco</creatorcontrib><creatorcontrib>Gobbi, Elena</creatorcontrib><creatorcontrib>Binetti, Giuliano</creatorcontrib><creatorcontrib>Cotelli, Maria</creatorcontrib><title>Effects of Transcranial Direct Current Stimulation on Episodic Memory in Amnestic Mild Cognitive Impairment: A Pilot Study</title><title>The journals of gerontology. Series B, Psychological sciences and social sciences</title><addtitle>J Gerontol B Psychol Sci Soc Sci</addtitle><description>Abstract
Objectives
Episodic memory is impaired in amnestic mild cognitive impairment (aMCI), which is posited as a potential prodromal form of Alzheimer’s disease. Reactivated existing memories become sensitive to modification during reconsolidation. There is evidence that the lateral prefrontal cortex (PFC) plays causal role in episodic memory reconsolidation. Transcranial direct current stimulation (tDCS) applied to the PFC after a contextual reminder enhanced episodic memory performance up to 1 month, conceivably through reconsolidation, in older adults with subjective memory complaints, a condition that may represent a “pre-mild cognitive impairment” stage. The aim of this pilot study was to test the effect of PFC-tDCS (anode over left lateral PFC, cathode over right supraorbital area) after a contextual reminder on episodic memory in older adults with aMCI.
Method
Older adults with aMCI learned a list of words. Twenty-four hours later, tDCS (Active or Sham) was applied after a contextual reminder. Memory retrieval (free recall and recognition) was tested 48 hrs and 1 month after the learning session.
Results
Active tDCS enhanced recognition memory relative to Sham stimulation.
Discussion
Modulating reconsolidation with PFC-tDCS might be a novel intervention to enhance episodic memories in aMCI.</description><subject>Aged</subject><subject>Cognitive Dysfunction - psychology</subject><subject>Cognitive Dysfunction - therapy</subject><subject>Double-Blind Method</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Memory and Learning Tests</subject><subject>Memory, Episodic</subject><subject>Mental Recall</subject><subject>Neuropsychological Tests</subject><subject>Pilot Projects</subject><subject>Transcranial Direct Current Stimulation - methods</subject><issn>1079-5014</issn><issn>1758-5368</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMFPwyAUxonRuDk9ejUcvdTBgJV6W-bUJTOaOM8NpbBgSqnQmtS_XpZOPfpC3oOXL7_3-AC4xOgGo4xMd8q7upjuih4TegTGOGU8YWTOj-MdpVnCEKYjcBbCO4qBU3oKRgSRjBFMx-BrpbWSbYBOw60XdZAxGVHBO-NjHy4771XdwtfW2K4SrXE1jGfVmOBKI-GTss730NRwYWsV2n3LVCVcul1tWvOp4No2wngbIbdwAV9M5fa0ruzPwYkWVVAXhzoBb_er7fIx2Tw_rJeLTSIpwW1CWZFiLTnKOFIZKRhJRSlZWtBSxydJOeIFZVJLpLkivGTz-EuNpSi0pFSSCbgeuI13H13cMbcmSFVVolauC_kME4TYHKNZlCaDVHoXglc6b7yxwvc5Rvne7nywOx_sjvqrA7orrCp_1T_-_s12XfMP6xt_rIyX</recordid><startdate>20200813</startdate><enddate>20200813</enddate><creator>Manenti, Rosa</creator><creator>Sandrini, Marco</creator><creator>Gobbi, Elena</creator><creator>Binetti, Giuliano</creator><creator>Cotelli, Maria</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20200813</creationdate><title>Effects of Transcranial Direct Current Stimulation on Episodic Memory in Amnestic Mild Cognitive Impairment: A Pilot Study</title><author>Manenti, Rosa ; Sandrini, Marco ; Gobbi, Elena ; Binetti, Giuliano ; Cotelli, Maria</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c431t-45b71fc80980e93b537adc57b4df93b37808b45cfc0f8e38d56017f1cabfc44c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Aged</topic><topic>Cognitive Dysfunction - psychology</topic><topic>Cognitive Dysfunction - therapy</topic><topic>Double-Blind Method</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Memory and Learning Tests</topic><topic>Memory, Episodic</topic><topic>Mental Recall</topic><topic>Neuropsychological Tests</topic><topic>Pilot Projects</topic><topic>Transcranial Direct Current Stimulation - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Manenti, Rosa</creatorcontrib><creatorcontrib>Sandrini, Marco</creatorcontrib><creatorcontrib>Gobbi, Elena</creatorcontrib><creatorcontrib>Binetti, Giuliano</creatorcontrib><creatorcontrib>Cotelli, Maria</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The journals of gerontology. Series B, Psychological sciences and social sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Manenti, Rosa</au><au>Sandrini, Marco</au><au>Gobbi, Elena</au><au>Binetti, Giuliano</au><au>Cotelli, Maria</au><au>Anderson, Nicole</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of Transcranial Direct Current Stimulation on Episodic Memory in Amnestic Mild Cognitive Impairment: A Pilot Study</atitle><jtitle>The journals of gerontology. Series B, Psychological sciences and social sciences</jtitle><addtitle>J Gerontol B Psychol Sci Soc Sci</addtitle><date>2020-08-13</date><risdate>2020</risdate><volume>75</volume><issue>7</issue><spage>1403</spage><epage>1413</epage><pages>1403-1413</pages><issn>1079-5014</issn><eissn>1758-5368</eissn><abstract>Abstract
Objectives
Episodic memory is impaired in amnestic mild cognitive impairment (aMCI), which is posited as a potential prodromal form of Alzheimer’s disease. Reactivated existing memories become sensitive to modification during reconsolidation. There is evidence that the lateral prefrontal cortex (PFC) plays causal role in episodic memory reconsolidation. Transcranial direct current stimulation (tDCS) applied to the PFC after a contextual reminder enhanced episodic memory performance up to 1 month, conceivably through reconsolidation, in older adults with subjective memory complaints, a condition that may represent a “pre-mild cognitive impairment” stage. The aim of this pilot study was to test the effect of PFC-tDCS (anode over left lateral PFC, cathode over right supraorbital area) after a contextual reminder on episodic memory in older adults with aMCI.
Method
Older adults with aMCI learned a list of words. Twenty-four hours later, tDCS (Active or Sham) was applied after a contextual reminder. Memory retrieval (free recall and recognition) was tested 48 hrs and 1 month after the learning session.
Results
Active tDCS enhanced recognition memory relative to Sham stimulation.
Discussion
Modulating reconsolidation with PFC-tDCS might be a novel intervention to enhance episodic memories in aMCI.</abstract><cop>US</cop><pub>Oxford University Press</pub><pmid>30395314</pmid><doi>10.1093/geronb/gby134</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Aged Cognitive Dysfunction - psychology Cognitive Dysfunction - therapy Double-Blind Method Female Humans Male Memory and Learning Tests Memory, Episodic Mental Recall Neuropsychological Tests Pilot Projects Transcranial Direct Current Stimulation - methods |
| title | Effects of Transcranial Direct Current Stimulation on Episodic Memory in Amnestic Mild Cognitive Impairment: A Pilot Study |
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