Novel Chimpanzee/Human Monoclonal Antibodies That Neutralize Anthrax Lethal Factor, and Evidence for Possible Synergy with Anti-Protective Antigen Antibody

Three chimpanzee Fabs reactive with lethal factor (LF) of anthrax toxin were isolated and converted into complete monoclonal antibodies (MAbs) with human γ1 heavy-chain constant regions. In a macrophage toxicity assay, two of the MAbs, LF10E and LF11H, neutralized lethal toxin (LT), a complex of LF...

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Veröffentlicht in:	Infection and Immunity 2009-09, Vol.77 (9), p.3902-3908
Hauptverfasser:	Chen, Zhaochun, Moayeri, Mahtab, Crown, Devorah, Emerson, Suzanne, Gorshkova, Inna, Schuck, Peter, Leppla, Stephen H, Purcell, Robert H
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Antibodies, Bacterial - immunology Antibodies, Monoclonal - immunology Antibody Affinity Antigens, Bacterial - immunology Applied microbiology Bacterial Toxins - immunology Bacteriology Biological and medical sciences Fundamental and applied biological sciences. Psychology Humans Immunoglobulin Fab Fragments - immunology Microbial Immunity and Vaccines Microbiology Miscellaneous Molecular Sequence Data Neutralization Tests Pan troglodytes Rats Rats, Inbred F344 Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
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