Long Term Surveillance of Renal Cell Carcinoma Recurrence Following Ablation using 2D and 3D Contrast-Enhanced Ultrasound
To evaluate efficacy of using 2D and 3D contrast enhanced ultrasound (CEUS) for surveillance of RCC recurrence in patients post-ablation and identify imaging hallmarks of recurrence. 53 patients >8 months post ablation of RCC provided informed consent for this IRB approved study. Patients receive...
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| Veröffentlicht in: | Urology (Ridgewood, N.J.) N.J.), 2018-11, Vol.121, p.189-196 |
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| creator | Calio, Brian P. Lyshchik, Andrej Li, Jingzhi Stanczak, Maria Shaw, Collette M. Adamo, Robert Liu, Ji-Bin Forsberg, Flemming Lallas, Costas D. Trabulsi, Edouard J. Eisenbrey, John R. |
| description | To evaluate efficacy of using 2D and 3D contrast enhanced ultrasound (CEUS) for surveillance of RCC recurrence in patients post-ablation and identify imaging hallmarks of recurrence.
53 patients >8 months post ablation of RCC provided informed consent for this IRB approved study. Patients received 2D and 3D CEUS examinations with Optison (GE Healthcare). Three radiologists of varying CEUS experience described enhancement characteristics, made a diagnosis of recurrence/no-recurrence, and quantified their diagnostic confidence levels.
Cases of RCC recurrence showed full ablation cavity enhancement with equal arrival times and intensity compared to the renal cortex. Lack of recurrence was characterized as a complete lack of enhancement within the cavity, or delayed enhancement stemming from the periphery of the ablation cavity. Sensitivity for detecting RCC recurrence was 100% for all readers and specificity was 90%-94%. Reader agreement ranged from 88% to 96%. No significant improvements were achieved with the addition of 3D CEUS, and its inclusion resulted in decreased reader confidence.
Contrast-enhanced ultrasound successfully identified all cases of RCC recurrence in this study. Importantly, some patients with complete response to treatment developed delayed enhancement at the periphery of the ablation cavity over time, corresponding to fat necrosis, scarring or granulation tissue within the ablation cavity. |
| doi_str_mv | 10.1016/j.urology.2018.05.053 |
| format | Article |
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53 patients >8 months post ablation of RCC provided informed consent for this IRB approved study. Patients received 2D and 3D CEUS examinations with Optison (GE Healthcare). Three radiologists of varying CEUS experience described enhancement characteristics, made a diagnosis of recurrence/no-recurrence, and quantified their diagnostic confidence levels.
Cases of RCC recurrence showed full ablation cavity enhancement with equal arrival times and intensity compared to the renal cortex. Lack of recurrence was characterized as a complete lack of enhancement within the cavity, or delayed enhancement stemming from the periphery of the ablation cavity. Sensitivity for detecting RCC recurrence was 100% for all readers and specificity was 90%-94%. Reader agreement ranged from 88% to 96%. No significant improvements were achieved with the addition of 3D CEUS, and its inclusion resulted in decreased reader confidence.
Contrast-enhanced ultrasound successfully identified all cases of RCC recurrence in this study. Importantly, some patients with complete response to treatment developed delayed enhancement at the periphery of the ablation cavity over time, corresponding to fat necrosis, scarring or granulation tissue within the ablation cavity.</description><identifier>ISSN: 0090-4295</identifier><identifier>EISSN: 1527-9995</identifier><identifier>DOI: 10.1016/j.urology.2018.05.053</identifier><identifier>PMID: 30384977</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Ablation Techniques - adverse effects ; Ablation Techniques - methods ; Aged ; Albumins - pharmacology ; Carcinoma, Renal Cell - pathology ; Carcinoma, Renal Cell - surgery ; Contrast Media - pharmacology ; Female ; Fluorocarbons - pharmacology ; Humans ; Image Enhancement - methods ; Kidney - diagnostic imaging ; Kidney Neoplasms - pathology ; Kidney Neoplasms - surgery ; Male ; Middle Aged ; Neoplasm Recurrence, Local - diagnosis ; Reproducibility of Results ; Ultrasonography - methods</subject><ispartof>Urology (Ridgewood, N.J.), 2018-11, Vol.121, p.189-196</ispartof><rights>2018 Elsevier Inc.</rights><rights>Copyright © 2018 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c365t-e2c129059b9eaf024375fe1099b7c7abd77e53c1460e71274c54d6554d8134f03</citedby><cites>FETCH-LOGICAL-c365t-e2c129059b9eaf024375fe1099b7c7abd77e53c1460e71274c54d6554d8134f03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S009042951830774X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30384977$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Calio, Brian P.</creatorcontrib><creatorcontrib>Lyshchik, Andrej</creatorcontrib><creatorcontrib>Li, Jingzhi</creatorcontrib><creatorcontrib>Stanczak, Maria</creatorcontrib><creatorcontrib>Shaw, Collette M.</creatorcontrib><creatorcontrib>Adamo, Robert</creatorcontrib><creatorcontrib>Liu, Ji-Bin</creatorcontrib><creatorcontrib>Forsberg, Flemming</creatorcontrib><creatorcontrib>Lallas, Costas D.</creatorcontrib><creatorcontrib>Trabulsi, Edouard J.</creatorcontrib><creatorcontrib>Eisenbrey, John R.</creatorcontrib><title>Long Term Surveillance of Renal Cell Carcinoma Recurrence Following Ablation using 2D and 3D Contrast-Enhanced Ultrasound</title><title>Urology (Ridgewood, N.J.)</title><addtitle>Urology</addtitle><description>To evaluate efficacy of using 2D and 3D contrast enhanced ultrasound (CEUS) for surveillance of RCC recurrence in patients post-ablation and identify imaging hallmarks of recurrence.
53 patients >8 months post ablation of RCC provided informed consent for this IRB approved study. Patients received 2D and 3D CEUS examinations with Optison (GE Healthcare). Three radiologists of varying CEUS experience described enhancement characteristics, made a diagnosis of recurrence/no-recurrence, and quantified their diagnostic confidence levels.
Cases of RCC recurrence showed full ablation cavity enhancement with equal arrival times and intensity compared to the renal cortex. Lack of recurrence was characterized as a complete lack of enhancement within the cavity, or delayed enhancement stemming from the periphery of the ablation cavity. Sensitivity for detecting RCC recurrence was 100% for all readers and specificity was 90%-94%. Reader agreement ranged from 88% to 96%. No significant improvements were achieved with the addition of 3D CEUS, and its inclusion resulted in decreased reader confidence.
Contrast-enhanced ultrasound successfully identified all cases of RCC recurrence in this study. Importantly, some patients with complete response to treatment developed delayed enhancement at the periphery of the ablation cavity over time, corresponding to fat necrosis, scarring or granulation tissue within the ablation cavity.</description><subject>Ablation Techniques - adverse effects</subject><subject>Ablation Techniques - methods</subject><subject>Aged</subject><subject>Albumins - pharmacology</subject><subject>Carcinoma, Renal Cell - pathology</subject><subject>Carcinoma, Renal Cell - surgery</subject><subject>Contrast Media - pharmacology</subject><subject>Female</subject><subject>Fluorocarbons - pharmacology</subject><subject>Humans</subject><subject>Image Enhancement - methods</subject><subject>Kidney - diagnostic imaging</subject><subject>Kidney Neoplasms - pathology</subject><subject>Kidney Neoplasms - surgery</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neoplasm Recurrence, Local - diagnosis</subject><subject>Reproducibility of Results</subject><subject>Ultrasonography - methods</subject><issn>0090-4295</issn><issn>1527-9995</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEFr3DAQhUVoSbZJfkKLjr14O7Isa3UqYZO0hYVCm5yFLI9TLbKUSnbC_vvK7LbXwjBCw3tvmI-Q9wzWDFj7ab-eU_Tx6bCugW3WIErxM7JiopaVUkq8ISsABVVTK3FB3uW8B4C2beU5ueDAN42SckUOuxie6AOmkf6c0ws6702wSONAf2Awnm7Rl2aSdSGOpgztnBIukvvofXx1xX7TeTO5GOicl299S03oKb-l2ximZPJU3YVfS2xPH_0yiHPor8jbwfiM16f3kjze3z1sv1a771--bW92leWtmCqsLasVCNUpNAPUDZdiQAZKddJK0_VSouCWNS2gZLVsrGj6VpS2YbwZgF-Sj8fc5xR_z5gnPbpscbkT45x1XeIFl2wji1QcpTbFnBMO-jm50aSDZqAX6nqvT9T1Ql2DKMWL78NpxdyN2P9z_cVcBJ-PAiyHvjhMOlu3QOxdQjvpPrr_rPgDyhiWTA</recordid><startdate>201811</startdate><enddate>201811</enddate><creator>Calio, Brian P.</creator><creator>Lyshchik, Andrej</creator><creator>Li, Jingzhi</creator><creator>Stanczak, Maria</creator><creator>Shaw, Collette M.</creator><creator>Adamo, Robert</creator><creator>Liu, Ji-Bin</creator><creator>Forsberg, Flemming</creator><creator>Lallas, Costas D.</creator><creator>Trabulsi, Edouard J.</creator><creator>Eisenbrey, John R.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201811</creationdate><title>Long Term Surveillance of Renal Cell Carcinoma Recurrence Following Ablation using 2D and 3D Contrast-Enhanced Ultrasound</title><author>Calio, Brian P. ; Lyshchik, Andrej ; Li, Jingzhi ; Stanczak, Maria ; Shaw, Collette M. ; Adamo, Robert ; Liu, Ji-Bin ; Forsberg, Flemming ; Lallas, Costas D. ; Trabulsi, Edouard J. ; Eisenbrey, John R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c365t-e2c129059b9eaf024375fe1099b7c7abd77e53c1460e71274c54d6554d8134f03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Ablation Techniques - adverse effects</topic><topic>Ablation Techniques - methods</topic><topic>Aged</topic><topic>Albumins - pharmacology</topic><topic>Carcinoma, Renal Cell - pathology</topic><topic>Carcinoma, Renal Cell - surgery</topic><topic>Contrast Media - pharmacology</topic><topic>Female</topic><topic>Fluorocarbons - pharmacology</topic><topic>Humans</topic><topic>Image Enhancement - methods</topic><topic>Kidney - diagnostic imaging</topic><topic>Kidney Neoplasms - pathology</topic><topic>Kidney Neoplasms - surgery</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neoplasm Recurrence, Local - diagnosis</topic><topic>Reproducibility of Results</topic><topic>Ultrasonography - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Calio, Brian P.</creatorcontrib><creatorcontrib>Lyshchik, Andrej</creatorcontrib><creatorcontrib>Li, Jingzhi</creatorcontrib><creatorcontrib>Stanczak, Maria</creatorcontrib><creatorcontrib>Shaw, Collette M.</creatorcontrib><creatorcontrib>Adamo, Robert</creatorcontrib><creatorcontrib>Liu, Ji-Bin</creatorcontrib><creatorcontrib>Forsberg, Flemming</creatorcontrib><creatorcontrib>Lallas, Costas D.</creatorcontrib><creatorcontrib>Trabulsi, Edouard J.</creatorcontrib><creatorcontrib>Eisenbrey, John R.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Urology (Ridgewood, N.J.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Calio, Brian P.</au><au>Lyshchik, Andrej</au><au>Li, Jingzhi</au><au>Stanczak, Maria</au><au>Shaw, Collette M.</au><au>Adamo, Robert</au><au>Liu, Ji-Bin</au><au>Forsberg, Flemming</au><au>Lallas, Costas D.</au><au>Trabulsi, Edouard J.</au><au>Eisenbrey, John R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Long Term Surveillance of Renal Cell Carcinoma Recurrence Following Ablation using 2D and 3D Contrast-Enhanced Ultrasound</atitle><jtitle>Urology (Ridgewood, N.J.)</jtitle><addtitle>Urology</addtitle><date>2018-11</date><risdate>2018</risdate><volume>121</volume><spage>189</spage><epage>196</epage><pages>189-196</pages><issn>0090-4295</issn><eissn>1527-9995</eissn><abstract>To evaluate efficacy of using 2D and 3D contrast enhanced ultrasound (CEUS) for surveillance of RCC recurrence in patients post-ablation and identify imaging hallmarks of recurrence.
53 patients >8 months post ablation of RCC provided informed consent for this IRB approved study. Patients received 2D and 3D CEUS examinations with Optison (GE Healthcare). Three radiologists of varying CEUS experience described enhancement characteristics, made a diagnosis of recurrence/no-recurrence, and quantified their diagnostic confidence levels.
Cases of RCC recurrence showed full ablation cavity enhancement with equal arrival times and intensity compared to the renal cortex. Lack of recurrence was characterized as a complete lack of enhancement within the cavity, or delayed enhancement stemming from the periphery of the ablation cavity. Sensitivity for detecting RCC recurrence was 100% for all readers and specificity was 90%-94%. Reader agreement ranged from 88% to 96%. No significant improvements were achieved with the addition of 3D CEUS, and its inclusion resulted in decreased reader confidence.
Contrast-enhanced ultrasound successfully identified all cases of RCC recurrence in this study. Importantly, some patients with complete response to treatment developed delayed enhancement at the periphery of the ablation cavity over time, corresponding to fat necrosis, scarring or granulation tissue within the ablation cavity.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>30384977</pmid><doi>10.1016/j.urology.2018.05.053</doi><tpages>8</tpages></addata></record> |
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| subjects | Ablation Techniques - adverse effects Ablation Techniques - methods Aged Albumins - pharmacology Carcinoma, Renal Cell - pathology Carcinoma, Renal Cell - surgery Contrast Media - pharmacology Female Fluorocarbons - pharmacology Humans Image Enhancement - methods Kidney - diagnostic imaging Kidney Neoplasms - pathology Kidney Neoplasms - surgery Male Middle Aged Neoplasm Recurrence, Local - diagnosis Reproducibility of Results Ultrasonography - methods |
| title | Long Term Surveillance of Renal Cell Carcinoma Recurrence Following Ablation using 2D and 3D Contrast-Enhanced Ultrasound |
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