Increased sesqui- and triterpene production by co-expression of HMG-CoA reductase and biotin carboxyl carrier protein in tobacco (Nicotiana benthamiana)

Terpenoids are the most diverse natural products with many industrial applications and are all synthesized from simple precursors, isopentenyl diphosphate (IPP) and its isomer dimethylallyl diphosphate (DMAPP). In plants, IPP is synthesized by two distinct metabolic pathways – cytosolic mevalonate (...

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Veröffentlicht in:	Metabolic engineering 2019-03, Vol.52, p.20-28
Hauptverfasser:	Lee, Ah-Reum, Kwon, Moonhyuk, Kang, Min-Kyoung, Kim, Jeonghan, Kim, Soo-Un, Ro, Dae-Kyun
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetyl Coenzyme A - metabolism Acetyl-CoA carboxylase Acetyl-CoA Carboxylase - metabolism Biotin carboxyl carrier protein Carrier Proteins - metabolism Cytosol - metabolism Fatty Acid Synthase, Type II - metabolism Fatty Acids - biosynthesis Hydroxymethylglutaryl CoA Reductases - genetics Hydroxymethylglutaryl CoA Reductases - metabolism Malonyl Coenzyme A - metabolism Mevalonate pathway Monocyclic Sesquiterpenes Nicotiana - genetics Nicotiana - metabolism Plant Leaves - metabolism Sesquiterpenes - metabolism Terpene Triterpenes - metabolism α -bisabolol
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