Senescent T Cells Predict the Development of Hyperglycemia in Humans
Senescent T cells have been implicated in chronic inflammatory and cardiovascular diseases. In this study, we explored the relationship between senescent T cells and glycemic status in a cohort of 805 participants by investigating the frequency of CD57 or CD28 senescent T cells in peripheral blood....
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| Veröffentlicht in: | Diabetes (New York, N.Y.) N.Y.), 2019-01, Vol.68 (1), p.156-162 |
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| container_title | Diabetes (New York, N.Y.) |
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| creator | Lee, Yong-Ho Kim, So Ra Han, Dai Hoon Yu, Hee Tae Han, Yoon Dae Kim, Jin Hee Kim, Soo Hyun Lee, Chan Joo Min, Byoung-Hoon Kim, Dong-Hyun Kim, Kyung Hwan Cho, Jin Won Lee, Won-Woo Shin, Eui-Cheol Park, Sungha |
| description | Senescent T cells have been implicated in chronic inflammatory and cardiovascular diseases. In this study, we explored the relationship between senescent T cells and glycemic status in a cohort of 805 participants by investigating the frequency of CD57
or CD28
senescent T cells in peripheral blood. Participants with normal glucose tolerance (NGT) with follow-up data (
= 149) were included to determine whether hyperglycemia (prediabetes or type 2 diabetes) developed during follow-up (mean 2.3 years). CD8
CD57
and CD8
CD28
T-cell frequencies were significantly higher in prediabetes and type 2 diabetes compared with NGT. Increased CD57
or CD28
cells in the CD8
T-cell subset were independently associated with hyperglycemia. Furthermore, among participants with baseline NGT, the frequency of CD8
CD57
T cells was an independent predictor of hyperglycemia development. Immunofluorescent analyses confirmed that CD8
CD57
T-cell infiltration was increased in visceral adipose tissue of patients with prediabetes or type 2 diabetes compared with those with NGT. Our data suggest that increased frequency of senescent CD8
T cells in the peripheral blood is associated with development of hyperglycemia. |
| doi_str_mv | 10.2337/db17-1218 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2129534782</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2129534782</sourcerecordid><originalsourceid>FETCH-LOGICAL-c348t-61cdf0ff096b35926b7f1582664df8ed63c06b970fff0dd1cc2e6971ea518b5c3</originalsourceid><addsrcrecordid>eNpd0E1LxDAQBuAgiruuHvwDEvCih2o-2qQ5yq66woKCK3grbTLRLv0yaYX996bs6kHmMId5eBlehM4puWGcy1tTUBlRRtMDNKWKq4gz-X6IpoRQFlGp5ASdeL8hhIgwx2jCCU-VjOUULV6hAa-h6fEaz6GqPH5xYErd4_4T8AK-oWq7ery3Fi-3HbiPaquhLnNcNng51HnjT9GRzSsPZ_s9Q28P9-v5Mlo9Pz7N71aR5nHaR4JqY4m1RImCJ4qJQlqapEyI2NgUjOCaiELJQCwxhmrNQChJIU9oWiSaz9DVLrdz7dcAvs_qMvxeVXkD7eAzRplKeCxTFujlP7ppB9eE74KSVMUJESqo653SrvXegc06V9a522aUZGO12VhtNlYb7MU-cShqMH_yt0v-A_47ckU</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2171945069</pqid></control><display><type>article</type><title>Senescent T Cells Predict the Development of Hyperglycemia in Humans</title><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><creator>Lee, Yong-Ho ; Kim, So Ra ; Han, Dai Hoon ; Yu, Hee Tae ; Han, Yoon Dae ; Kim, Jin Hee ; Kim, Soo Hyun ; Lee, Chan Joo ; Min, Byoung-Hoon ; Kim, Dong-Hyun ; Kim, Kyung Hwan ; Cho, Jin Won ; Lee, Won-Woo ; Shin, Eui-Cheol ; Park, Sungha</creator><creatorcontrib>Lee, Yong-Ho ; Kim, So Ra ; Han, Dai Hoon ; Yu, Hee Tae ; Han, Yoon Dae ; Kim, Jin Hee ; Kim, Soo Hyun ; Lee, Chan Joo ; Min, Byoung-Hoon ; Kim, Dong-Hyun ; Kim, Kyung Hwan ; Cho, Jin Won ; Lee, Won-Woo ; Shin, Eui-Cheol ; Park, Sungha</creatorcontrib><description>Senescent T cells have been implicated in chronic inflammatory and cardiovascular diseases. In this study, we explored the relationship between senescent T cells and glycemic status in a cohort of 805 participants by investigating the frequency of CD57
or CD28
senescent T cells in peripheral blood. Participants with normal glucose tolerance (NGT) with follow-up data (
= 149) were included to determine whether hyperglycemia (prediabetes or type 2 diabetes) developed during follow-up (mean 2.3 years). CD8
CD57
and CD8
CD28
T-cell frequencies were significantly higher in prediabetes and type 2 diabetes compared with NGT. Increased CD57
or CD28
cells in the CD8
T-cell subset were independently associated with hyperglycemia. Furthermore, among participants with baseline NGT, the frequency of CD8
CD57
T cells was an independent predictor of hyperglycemia development. Immunofluorescent analyses confirmed that CD8
CD57
T-cell infiltration was increased in visceral adipose tissue of patients with prediabetes or type 2 diabetes compared with those with NGT. Our data suggest that increased frequency of senescent CD8
T cells in the peripheral blood is associated with development of hyperglycemia.</description><identifier>ISSN: 0012-1797</identifier><identifier>EISSN: 1939-327X</identifier><identifier>DOI: 10.2337/db17-1218</identifier><identifier>PMID: 30389747</identifier><language>eng</language><publisher>United States: American Diabetes Association</publisher><subject>Adipocytes ; Adipose tissue ; Cardiovascular diseases ; CD28 antigen ; CD57 antigen ; CD8 antigen ; Cells ; Diabetes ; Diabetes mellitus ; Diabetes mellitus (non-insulin dependent) ; Glucose ; Glucose tolerance ; Glycemic index ; Hyperglycemia ; Immunological tolerance ; Lymphocytes T ; Peripheral blood</subject><ispartof>Diabetes (New York, N.Y.), 2019-01, Vol.68 (1), p.156-162</ispartof><rights>2018 by the American Diabetes Association.</rights><rights>Copyright American Diabetes Association Jan 1, 2019</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c348t-61cdf0ff096b35926b7f1582664df8ed63c06b970fff0dd1cc2e6971ea518b5c3</citedby><cites>FETCH-LOGICAL-c348t-61cdf0ff096b35926b7f1582664df8ed63c06b970fff0dd1cc2e6971ea518b5c3</cites><orcidid>0000-0002-5347-9591 ; 0000-0002-6308-9503 ; 0000-0002-8756-409X ; 0000-0001-5362-478X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30389747$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lee, Yong-Ho</creatorcontrib><creatorcontrib>Kim, So Ra</creatorcontrib><creatorcontrib>Han, Dai Hoon</creatorcontrib><creatorcontrib>Yu, Hee Tae</creatorcontrib><creatorcontrib>Han, Yoon Dae</creatorcontrib><creatorcontrib>Kim, Jin Hee</creatorcontrib><creatorcontrib>Kim, Soo Hyun</creatorcontrib><creatorcontrib>Lee, Chan Joo</creatorcontrib><creatorcontrib>Min, Byoung-Hoon</creatorcontrib><creatorcontrib>Kim, Dong-Hyun</creatorcontrib><creatorcontrib>Kim, Kyung Hwan</creatorcontrib><creatorcontrib>Cho, Jin Won</creatorcontrib><creatorcontrib>Lee, Won-Woo</creatorcontrib><creatorcontrib>Shin, Eui-Cheol</creatorcontrib><creatorcontrib>Park, Sungha</creatorcontrib><title>Senescent T Cells Predict the Development of Hyperglycemia in Humans</title><title>Diabetes (New York, N.Y.)</title><addtitle>Diabetes</addtitle><description>Senescent T cells have been implicated in chronic inflammatory and cardiovascular diseases. In this study, we explored the relationship between senescent T cells and glycemic status in a cohort of 805 participants by investigating the frequency of CD57
or CD28
senescent T cells in peripheral blood. Participants with normal glucose tolerance (NGT) with follow-up data (
= 149) were included to determine whether hyperglycemia (prediabetes or type 2 diabetes) developed during follow-up (mean 2.3 years). CD8
CD57
and CD8
CD28
T-cell frequencies were significantly higher in prediabetes and type 2 diabetes compared with NGT. Increased CD57
or CD28
cells in the CD8
T-cell subset were independently associated with hyperglycemia. Furthermore, among participants with baseline NGT, the frequency of CD8
CD57
T cells was an independent predictor of hyperglycemia development. Immunofluorescent analyses confirmed that CD8
CD57
T-cell infiltration was increased in visceral adipose tissue of patients with prediabetes or type 2 diabetes compared with those with NGT. Our data suggest that increased frequency of senescent CD8
T cells in the peripheral blood is associated with development of hyperglycemia.</description><subject>Adipocytes</subject><subject>Adipose tissue</subject><subject>Cardiovascular diseases</subject><subject>CD28 antigen</subject><subject>CD57 antigen</subject><subject>CD8 antigen</subject><subject>Cells</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Diabetes mellitus (non-insulin dependent)</subject><subject>Glucose</subject><subject>Glucose tolerance</subject><subject>Glycemic index</subject><subject>Hyperglycemia</subject><subject>Immunological tolerance</subject><subject>Lymphocytes T</subject><subject>Peripheral blood</subject><issn>0012-1797</issn><issn>1939-327X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNpd0E1LxDAQBuAgiruuHvwDEvCih2o-2qQ5yq66woKCK3grbTLRLv0yaYX996bs6kHmMId5eBlehM4puWGcy1tTUBlRRtMDNKWKq4gz-X6IpoRQFlGp5ASdeL8hhIgwx2jCCU-VjOUULV6hAa-h6fEaz6GqPH5xYErd4_4T8AK-oWq7ery3Fi-3HbiPaquhLnNcNng51HnjT9GRzSsPZ_s9Q28P9-v5Mlo9Pz7N71aR5nHaR4JqY4m1RImCJ4qJQlqapEyI2NgUjOCaiELJQCwxhmrNQChJIU9oWiSaz9DVLrdz7dcAvs_qMvxeVXkD7eAzRplKeCxTFujlP7ppB9eE74KSVMUJESqo653SrvXegc06V9a522aUZGO12VhtNlYb7MU-cShqMH_yt0v-A_47ckU</recordid><startdate>201901</startdate><enddate>201901</enddate><creator>Lee, Yong-Ho</creator><creator>Kim, So Ra</creator><creator>Han, Dai Hoon</creator><creator>Yu, Hee Tae</creator><creator>Han, Yoon Dae</creator><creator>Kim, Jin Hee</creator><creator>Kim, Soo Hyun</creator><creator>Lee, Chan Joo</creator><creator>Min, Byoung-Hoon</creator><creator>Kim, Dong-Hyun</creator><creator>Kim, Kyung Hwan</creator><creator>Cho, Jin Won</creator><creator>Lee, Won-Woo</creator><creator>Shin, Eui-Cheol</creator><creator>Park, Sungha</creator><general>American Diabetes Association</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-5347-9591</orcidid><orcidid>https://orcid.org/0000-0002-6308-9503</orcidid><orcidid>https://orcid.org/0000-0002-8756-409X</orcidid><orcidid>https://orcid.org/0000-0001-5362-478X</orcidid></search><sort><creationdate>201901</creationdate><title>Senescent T Cells Predict the Development of Hyperglycemia in Humans</title><author>Lee, Yong-Ho ; Kim, So Ra ; Han, Dai Hoon ; Yu, Hee Tae ; Han, Yoon Dae ; Kim, Jin Hee ; Kim, Soo Hyun ; Lee, Chan Joo ; Min, Byoung-Hoon ; Kim, Dong-Hyun ; Kim, Kyung Hwan ; Cho, Jin Won ; Lee, Won-Woo ; Shin, Eui-Cheol ; Park, Sungha</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c348t-61cdf0ff096b35926b7f1582664df8ed63c06b970fff0dd1cc2e6971ea518b5c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adipocytes</topic><topic>Adipose tissue</topic><topic>Cardiovascular diseases</topic><topic>CD28 antigen</topic><topic>CD57 antigen</topic><topic>CD8 antigen</topic><topic>Cells</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>Diabetes mellitus (non-insulin dependent)</topic><topic>Glucose</topic><topic>Glucose tolerance</topic><topic>Glycemic index</topic><topic>Hyperglycemia</topic><topic>Immunological tolerance</topic><topic>Lymphocytes T</topic><topic>Peripheral blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, Yong-Ho</creatorcontrib><creatorcontrib>Kim, So Ra</creatorcontrib><creatorcontrib>Han, Dai Hoon</creatorcontrib><creatorcontrib>Yu, Hee Tae</creatorcontrib><creatorcontrib>Han, Yoon Dae</creatorcontrib><creatorcontrib>Kim, Jin Hee</creatorcontrib><creatorcontrib>Kim, Soo Hyun</creatorcontrib><creatorcontrib>Lee, Chan Joo</creatorcontrib><creatorcontrib>Min, Byoung-Hoon</creatorcontrib><creatorcontrib>Kim, Dong-Hyun</creatorcontrib><creatorcontrib>Kim, Kyung Hwan</creatorcontrib><creatorcontrib>Cho, Jin Won</creatorcontrib><creatorcontrib>Lee, Won-Woo</creatorcontrib><creatorcontrib>Shin, Eui-Cheol</creatorcontrib><creatorcontrib>Park, Sungha</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Diabetes (New York, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, Yong-Ho</au><au>Kim, So Ra</au><au>Han, Dai Hoon</au><au>Yu, Hee Tae</au><au>Han, Yoon Dae</au><au>Kim, Jin Hee</au><au>Kim, Soo Hyun</au><au>Lee, Chan Joo</au><au>Min, Byoung-Hoon</au><au>Kim, Dong-Hyun</au><au>Kim, Kyung Hwan</au><au>Cho, Jin Won</au><au>Lee, Won-Woo</au><au>Shin, Eui-Cheol</au><au>Park, Sungha</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Senescent T Cells Predict the Development of Hyperglycemia in Humans</atitle><jtitle>Diabetes (New York, N.Y.)</jtitle><addtitle>Diabetes</addtitle><date>2019-01</date><risdate>2019</risdate><volume>68</volume><issue>1</issue><spage>156</spage><epage>162</epage><pages>156-162</pages><issn>0012-1797</issn><eissn>1939-327X</eissn><abstract>Senescent T cells have been implicated in chronic inflammatory and cardiovascular diseases. In this study, we explored the relationship between senescent T cells and glycemic status in a cohort of 805 participants by investigating the frequency of CD57
or CD28
senescent T cells in peripheral blood. Participants with normal glucose tolerance (NGT) with follow-up data (
= 149) were included to determine whether hyperglycemia (prediabetes or type 2 diabetes) developed during follow-up (mean 2.3 years). CD8
CD57
and CD8
CD28
T-cell frequencies were significantly higher in prediabetes and type 2 diabetes compared with NGT. Increased CD57
or CD28
cells in the CD8
T-cell subset were independently associated with hyperglycemia. Furthermore, among participants with baseline NGT, the frequency of CD8
CD57
T cells was an independent predictor of hyperglycemia development. Immunofluorescent analyses confirmed that CD8
CD57
T-cell infiltration was increased in visceral adipose tissue of patients with prediabetes or type 2 diabetes compared with those with NGT. Our data suggest that increased frequency of senescent CD8
T cells in the peripheral blood is associated with development of hyperglycemia.</abstract><cop>United States</cop><pub>American Diabetes Association</pub><pmid>30389747</pmid><doi>10.2337/db17-1218</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-5347-9591</orcidid><orcidid>https://orcid.org/0000-0002-6308-9503</orcidid><orcidid>https://orcid.org/0000-0002-8756-409X</orcidid><orcidid>https://orcid.org/0000-0001-5362-478X</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
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| ispartof | Diabetes (New York, N.Y.), 2019-01, Vol.68 (1), p.156-162 |
| issn | 0012-1797 1939-327X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2129534782 |
| source | EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Adipocytes Adipose tissue Cardiovascular diseases CD28 antigen CD57 antigen CD8 antigen Cells Diabetes Diabetes mellitus Diabetes mellitus (non-insulin dependent) Glucose Glucose tolerance Glycemic index Hyperglycemia Immunological tolerance Lymphocytes T Peripheral blood |
| title | Senescent T Cells Predict the Development of Hyperglycemia in Humans |
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