Are hypothyroidism and hypogonadism clinically relevant in patients with malignant gliomas? A longitudinal trial in patients with glioma
•Standard postsurgical therapy induces hormonal deficiencies of pituitary and downstream gland.•Along with concomitant radiochemotherapy acute “non thyroidal” illness was observed.•Secondary hypothyroidism developed during follow up in around 10% of patients.•Half of premenopausal women developed ea...
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| Veröffentlicht in: | Radiotherapy and oncology 2019-01, Vol.130, p.139-148 |
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| creator | Handisurya, Ammon Rumpold, Tamara Caucig-Lütgendorf, Carola Flechl, Birgit Preusser, Matthias Ilhan-Mutlu, Aysegül Dieckmann, Karin Widhalm, Georg Grisold, Anna Wöhrer, Adelheid Hainfellner, Johannes Ristl, Robin Kurz, Christine Marosi, Christine Gessl, Alois Hassler, Marco |
| description | •Standard postsurgical therapy induces hormonal deficiencies of pituitary and downstream gland.•Along with concomitant radiochemotherapy acute “non thyroidal” illness was observed.•Secondary hypothyroidism developed during follow up in around 10% of patients.•Half of premenopausal women developed early menopause, the percentage of men with lowered testosterone levels appears much lower.•Providing adequate hormonal replacement could contribute to decrease fatigue and listlessness.
So far, the development and course of therapy-induced deficiencies in hypothalamic–pituitary hormones in adult patients with malignant gliomas has not received much attention. However, such deficiencies may impact patient’s quality of life substantially.
In this monocentric longitudinal trial, we examined hormonal levels of TSH, T3, T4, fT3, fT4, FSH, LH, testosterone, estradiol and prolactin in patients with malignant high grade gliomas before the start of radiochemotherapy (RCT), at the end of RCT and then every three months for newly diagnosed patients and every six months in patients diagnosed more than two years before study inclusion. Growth hormone was not measured in this trial.
436 patients (198 female, 238 male) with high-grade gliomas, aged 19–83 years (median 50 years), were included in this study. Low levels of thyroid hormones were observed in around 10% of patients within the first six months of follow up and increasingly after 36 months. Half of premenopausal women at study entry developed premature menopause, 35% showed hyperprolactinemia. Low testosterone levels were measured in 37% of men aged less than 50 years and in 35/63 (55%) of men aged 50 years or older.
The results of this study show that a significant percentage of patients with malignant gliomas develop hormonal deficiencies mandating regular clinical follow up, state of the art counseling and if clinically necessary substitution therapy. |
| doi_str_mv | 10.1016/j.radonc.2018.10.014 |
| format | Article |
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So far, the development and course of therapy-induced deficiencies in hypothalamic–pituitary hormones in adult patients with malignant gliomas has not received much attention. However, such deficiencies may impact patient’s quality of life substantially.
In this monocentric longitudinal trial, we examined hormonal levels of TSH, T3, T4, fT3, fT4, FSH, LH, testosterone, estradiol and prolactin in patients with malignant high grade gliomas before the start of radiochemotherapy (RCT), at the end of RCT and then every three months for newly diagnosed patients and every six months in patients diagnosed more than two years before study inclusion. Growth hormone was not measured in this trial.
436 patients (198 female, 238 male) with high-grade gliomas, aged 19–83 years (median 50 years), were included in this study. Low levels of thyroid hormones were observed in around 10% of patients within the first six months of follow up and increasingly after 36 months. Half of premenopausal women at study entry developed premature menopause, 35% showed hyperprolactinemia. Low testosterone levels were measured in 37% of men aged less than 50 years and in 35/63 (55%) of men aged 50 years or older.
The results of this study show that a significant percentage of patients with malignant gliomas develop hormonal deficiencies mandating regular clinical follow up, state of the art counseling and if clinically necessary substitution therapy.</description><identifier>ISSN: 0167-8140</identifier><identifier>EISSN: 1879-0887</identifier><identifier>DOI: 10.1016/j.radonc.2018.10.014</identifier><identifier>PMID: 30389240</identifier><language>eng</language><publisher>Ireland: Elsevier B.V</publisher><subject>Adult ; Adult brain tumor patients ; Aged ; Aged, 80 and over ; Brain Neoplasms - blood ; Brain Neoplasms - therapy ; Chemoradiotherapy - adverse effects ; Female ; Glioma - blood ; Glioma - therapy ; Humans ; Hypogonadism - etiology ; Hypothalamic–pituitary hormones ; Hypothyroidism - etiology ; Male ; Middle Aged ; Prolactin - blood ; Prospective Studies ; Radiation induced hormonal deficits ; Testosterone - blood ; Thyroid Hormones - blood</subject><ispartof>Radiotherapy and oncology, 2019-01, Vol.130, p.139-148</ispartof><rights>2018 Elsevier B.V.</rights><rights>Copyright © 2018 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c362t-3231966cc170a30c9fb815d5c400fadb64c41ec75d9bfee264019c4a06ed31a33</citedby><cites>FETCH-LOGICAL-c362t-3231966cc170a30c9fb815d5c400fadb64c41ec75d9bfee264019c4a06ed31a33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.radonc.2018.10.014$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,45974</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30389240$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Handisurya, Ammon</creatorcontrib><creatorcontrib>Rumpold, Tamara</creatorcontrib><creatorcontrib>Caucig-Lütgendorf, Carola</creatorcontrib><creatorcontrib>Flechl, Birgit</creatorcontrib><creatorcontrib>Preusser, Matthias</creatorcontrib><creatorcontrib>Ilhan-Mutlu, Aysegül</creatorcontrib><creatorcontrib>Dieckmann, Karin</creatorcontrib><creatorcontrib>Widhalm, Georg</creatorcontrib><creatorcontrib>Grisold, Anna</creatorcontrib><creatorcontrib>Wöhrer, Adelheid</creatorcontrib><creatorcontrib>Hainfellner, Johannes</creatorcontrib><creatorcontrib>Ristl, Robin</creatorcontrib><creatorcontrib>Kurz, Christine</creatorcontrib><creatorcontrib>Marosi, Christine</creatorcontrib><creatorcontrib>Gessl, Alois</creatorcontrib><creatorcontrib>Hassler, Marco</creatorcontrib><title>Are hypothyroidism and hypogonadism clinically relevant in patients with malignant gliomas? A longitudinal trial in patients with glioma</title><title>Radiotherapy and oncology</title><addtitle>Radiother Oncol</addtitle><description>•Standard postsurgical therapy induces hormonal deficiencies of pituitary and downstream gland.•Along with concomitant radiochemotherapy acute “non thyroidal” illness was observed.•Secondary hypothyroidism developed during follow up in around 10% of patients.•Half of premenopausal women developed early menopause, the percentage of men with lowered testosterone levels appears much lower.•Providing adequate hormonal replacement could contribute to decrease fatigue and listlessness.
So far, the development and course of therapy-induced deficiencies in hypothalamic–pituitary hormones in adult patients with malignant gliomas has not received much attention. However, such deficiencies may impact patient’s quality of life substantially.
In this monocentric longitudinal trial, we examined hormonal levels of TSH, T3, T4, fT3, fT4, FSH, LH, testosterone, estradiol and prolactin in patients with malignant high grade gliomas before the start of radiochemotherapy (RCT), at the end of RCT and then every three months for newly diagnosed patients and every six months in patients diagnosed more than two years before study inclusion. Growth hormone was not measured in this trial.
436 patients (198 female, 238 male) with high-grade gliomas, aged 19–83 years (median 50 years), were included in this study. Low levels of thyroid hormones were observed in around 10% of patients within the first six months of follow up and increasingly after 36 months. Half of premenopausal women at study entry developed premature menopause, 35% showed hyperprolactinemia. Low testosterone levels were measured in 37% of men aged less than 50 years and in 35/63 (55%) of men aged 50 years or older.
The results of this study show that a significant percentage of patients with malignant gliomas develop hormonal deficiencies mandating regular clinical follow up, state of the art counseling and if clinically necessary substitution therapy.</description><subject>Adult</subject><subject>Adult brain tumor patients</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Brain Neoplasms - blood</subject><subject>Brain Neoplasms - therapy</subject><subject>Chemoradiotherapy - adverse effects</subject><subject>Female</subject><subject>Glioma - blood</subject><subject>Glioma - therapy</subject><subject>Humans</subject><subject>Hypogonadism - etiology</subject><subject>Hypothalamic–pituitary hormones</subject><subject>Hypothyroidism - etiology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Prolactin - blood</subject><subject>Prospective Studies</subject><subject>Radiation induced hormonal deficits</subject><subject>Testosterone - blood</subject><subject>Thyroid Hormones - blood</subject><issn>0167-8140</issn><issn>1879-0887</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc9OGzEQxq2qVUmBN0DIx142Ha-d_XOhilChlZB6gbPl2LOJI68dbAeUN-hj12GBS6VextLn3zejmY-QCwZzBqz5tp1HZYLX8xpYV6Q5MPGBzFjX9hV0XfuRzArWVh0TcEK-pLQFgBp4-5mccOBdXwuYkT_LiHRz2IW8OcRgjU0jVd68SOvg1YugnfVWK-cONKLDJ-UztZ7uVLboc6LPNm_oqJxd--PX2tkwqvSdLqkLfm3z3livHM3RlvqPccLPyKdBuYTnr-8pebj5cX_9s7r7ffvrenlXad7UueI1Z33TaM1aUBx0P6w6tjALLQAGZVaN0IKhbhemXw2IdSOA9VooaNBwpjg_JV-nvrsYHveYshxt0uic8hj2Sdas7hdccN4WVEyojiGliIPcRTuqeJAM5DEDuZVTBvKYwVEtGRTb5euE_WpE8256O3oBriYAy55PFqNMutxDo7ERdZYm2P9P-AuyeZ0m</recordid><startdate>201901</startdate><enddate>201901</enddate><creator>Handisurya, Ammon</creator><creator>Rumpold, Tamara</creator><creator>Caucig-Lütgendorf, Carola</creator><creator>Flechl, Birgit</creator><creator>Preusser, Matthias</creator><creator>Ilhan-Mutlu, Aysegül</creator><creator>Dieckmann, Karin</creator><creator>Widhalm, Georg</creator><creator>Grisold, Anna</creator><creator>Wöhrer, Adelheid</creator><creator>Hainfellner, Johannes</creator><creator>Ristl, Robin</creator><creator>Kurz, Christine</creator><creator>Marosi, Christine</creator><creator>Gessl, Alois</creator><creator>Hassler, Marco</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201901</creationdate><title>Are hypothyroidism and hypogonadism clinically relevant in patients with malignant gliomas? 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A longitudinal trial in patients with glioma</atitle><jtitle>Radiotherapy and oncology</jtitle><addtitle>Radiother Oncol</addtitle><date>2019-01</date><risdate>2019</risdate><volume>130</volume><spage>139</spage><epage>148</epage><pages>139-148</pages><issn>0167-8140</issn><eissn>1879-0887</eissn><abstract>•Standard postsurgical therapy induces hormonal deficiencies of pituitary and downstream gland.•Along with concomitant radiochemotherapy acute “non thyroidal” illness was observed.•Secondary hypothyroidism developed during follow up in around 10% of patients.•Half of premenopausal women developed early menopause, the percentage of men with lowered testosterone levels appears much lower.•Providing adequate hormonal replacement could contribute to decrease fatigue and listlessness.
So far, the development and course of therapy-induced deficiencies in hypothalamic–pituitary hormones in adult patients with malignant gliomas has not received much attention. However, such deficiencies may impact patient’s quality of life substantially.
In this monocentric longitudinal trial, we examined hormonal levels of TSH, T3, T4, fT3, fT4, FSH, LH, testosterone, estradiol and prolactin in patients with malignant high grade gliomas before the start of radiochemotherapy (RCT), at the end of RCT and then every three months for newly diagnosed patients and every six months in patients diagnosed more than two years before study inclusion. Growth hormone was not measured in this trial.
436 patients (198 female, 238 male) with high-grade gliomas, aged 19–83 years (median 50 years), were included in this study. Low levels of thyroid hormones were observed in around 10% of patients within the first six months of follow up and increasingly after 36 months. Half of premenopausal women at study entry developed premature menopause, 35% showed hyperprolactinemia. Low testosterone levels were measured in 37% of men aged less than 50 years and in 35/63 (55%) of men aged 50 years or older.
The results of this study show that a significant percentage of patients with malignant gliomas develop hormonal deficiencies mandating regular clinical follow up, state of the art counseling and if clinically necessary substitution therapy.</abstract><cop>Ireland</cop><pub>Elsevier B.V</pub><pmid>30389240</pmid><doi>10.1016/j.radonc.2018.10.014</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0167-8140 |
| ispartof | Radiotherapy and oncology, 2019-01, Vol.130, p.139-148 |
| issn | 0167-8140 1879-0887 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adult Adult brain tumor patients Aged Aged, 80 and over Brain Neoplasms - blood Brain Neoplasms - therapy Chemoradiotherapy - adverse effects Female Glioma - blood Glioma - therapy Humans Hypogonadism - etiology Hypothalamic–pituitary hormones Hypothyroidism - etiology Male Middle Aged Prolactin - blood Prospective Studies Radiation induced hormonal deficits Testosterone - blood Thyroid Hormones - blood |
| title | Are hypothyroidism and hypogonadism clinically relevant in patients with malignant gliomas? A longitudinal trial in patients with glioma |
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