Real-Time Monitoring of NDM‑1 Activity in Live Bacterial Cells by Isothermal Titration Calorimetry: A New Approach To Measure Inhibition of Antibiotic-Resistant Bacteria

The “superbug” infection caused by New Delhi metallo-β-lactamase (NDM-1) has become an emerging threat. Monitoring NDM-1 has proven challenging due to its shuttling between pathogenic bacteria. Here, we report an isothermal titration calorimetry (ITC) method that can monitor activity and inhibition...

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Veröffentlicht in:	ACS infectious diseases 2018-12, Vol.4 (12), p.1671-1678
Hauptverfasser:	Zhang, Yue-Juan, Wang, Wen-Ming, Oelschlaeger, Peter, Chen, Cheng, Lei, Jin-E, Lv, Miao, Yang, Ke-Wu
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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