Pyrazinamide drug resistance in RpsA mutant (∆438A) of Mycobacterium tuberculosis: Dynamics of essential motions and free‐energy landscape analysis

Pyrazinamide is an essential first‐line antitubercular drug which plays pivotal role in tuberculosis treatment. It is a prodrug that requires amide hydrolysis by mycobacterial pyrazinamidase enzyme for conversion into pyrazinoic acid (POA). POA is known to target ribosomal protein S1 (RpsA), asparta...

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Veröffentlicht in:	Journal of cellular biochemistry 2019-05, Vol.120 (5), p.7386-7402
Hauptverfasser:	Singh, Aditi, Somvanshi, Pallavi, Grover, Abhinav
Format:	Artikel
Sprache:	eng
Schlagworte:	antitubercular Binding sites Computer simulation Deletion mutant Drug interaction Drug interactions Drug resistance Energy free‐energy landscape Molecular dynamics Mutation Mycobacterium tuberculosis Protein structure Proteins Pyrazinamide pyrazinamide resistance pyrazinoic acid Ribosomal protein S1 Three dimensional models Tuberculosis
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