C‐reactive protein levels in acute respiratory exacerbations of cystic fibrosis
C‐reactive protein (CRP) levels increase in response to bacterial infection and have been used to guide the use of antibiotics. We assessed CRP levels in a cohort of patients with cystic fibrosis (CF) admitted to hospital with an exacerbation of their lung disease, requiring treatment with broad‐spe...
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| Veröffentlicht in: | Internal medicine journal 2018-11, Vol.48 (11), p.1392-1395 |
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| container_end_page | 1395 |
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| container_issue | 11 |
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| container_title | Internal medicine journal |
| container_volume | 48 |
| creator | Kathriachchige, Gayan Daley, Christopher Pallin, Michael Polkinghorne, Kevan King, Paul T. |
| description | C‐reactive protein (CRP) levels increase in response to bacterial infection and have been used to guide the use of antibiotics. We assessed CRP levels in a cohort of patients with cystic fibrosis (CF) admitted to hospital with an exacerbation of their lung disease, requiring treatment with broad‐spectrum antibiotics. In this group, most subjects had CRP levels of less than 20 mg/L, including patients who had pneumonia. The clinical utility of the CRP in guiding antibiotic use in exacerbations of CF is limited. |
| doi_str_mv | 10.1111/imj.14106 |
| format | Article |
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We assessed CRP levels in a cohort of patients with cystic fibrosis (CF) admitted to hospital with an exacerbation of their lung disease, requiring treatment with broad‐spectrum antibiotics. In this group, most subjects had CRP levels of less than 20 mg/L, including patients who had pneumonia. 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We assessed CRP levels in a cohort of patients with cystic fibrosis (CF) admitted to hospital with an exacerbation of their lung disease, requiring treatment with broad‐spectrum antibiotics. In this group, most subjects had CRP levels of less than 20 mg/L, including patients who had pneumonia. The clinical utility of the CRP in guiding antibiotic use in exacerbations of CF is limited.</description><subject>Adult</subject><subject>Anti-Bacterial Agents - therapeutic use</subject><subject>antibiotic</subject><subject>Antibiotics</subject><subject>Bacterial Infections - blood</subject><subject>Bacterial Infections - drug therapy</subject><subject>Biomarkers - blood</subject><subject>C-Reactive Protein - metabolism</subject><subject>Case-Control Studies</subject><subject>Cystic fibrosis</subject><subject>Cystic Fibrosis - blood</subject><subject>Cystic Fibrosis - microbiology</subject><subject>C‐reactive protein</subject><subject>exacerbation</subject><subject>Female</subject><subject>Forced Expiratory Volume</subject><subject>Humans</subject><subject>Length of Stay</subject><subject>Lung diseases</subject><subject>Male</subject><subject>Patients</subject><subject>pneumonia</subject><subject>Retrospective Studies</subject><subject>Severity of Illness Index</subject><subject>Tomography, X-Ray Computed</subject><subject>Young Adult</subject><issn>1444-0903</issn><issn>1445-5994</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kEtOwzAQhi0EoqWw4AIoEhtYpLVjO3aWqOJRVISQYB057kRylUexk0J2HIEzchLcprBAYhYzs_j0a-ZD6JTgMfE1MeVyTBjB8R4aEsZ4yJOE7W93FuIE0wE6cm6JMRE0YYdoQDGVghIyRE_Tr49PC0o3Zg3BytYNmCooYA2FC_ymdNtAYMGtjFVNbbsA3pUGm6nG1JUL6jzQnWuMDnKT2doZd4wOclU4ONnNEXq5uX6e3oXzx9vZ9GoeasppHMpY0FjnHBSOic5AaqZzSTiWuRBcssw3HeEk5gLrPFoQYHQRcS0ijoUWQEfoos_1R7-24Jq0NE5DUagK6talEYkSTokUxKPnf9Bl3drKX7ehhPTmEuapy57S_g9nIU9X1pTKdinB6cZz6j2nW8-ePdsltlkJi1_yR6wHJj3wZgro_k9KZw_3feQ3EHiHBQ</recordid><startdate>201811</startdate><enddate>201811</enddate><creator>Kathriachchige, Gayan</creator><creator>Daley, Christopher</creator><creator>Pallin, Michael</creator><creator>Polkinghorne, Kevan</creator><creator>King, Paul T.</creator><general>John Wiley & Sons Australia, Ltd</general><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-5197-1163</orcidid></search><sort><creationdate>201811</creationdate><title>C‐reactive protein levels in acute respiratory exacerbations of cystic fibrosis</title><author>Kathriachchige, Gayan ; 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We assessed CRP levels in a cohort of patients with cystic fibrosis (CF) admitted to hospital with an exacerbation of their lung disease, requiring treatment with broad‐spectrum antibiotics. In this group, most subjects had CRP levels of less than 20 mg/L, including patients who had pneumonia. The clinical utility of the CRP in guiding antibiotic use in exacerbations of CF is limited.</abstract><cop>Melbourne</cop><pub>John Wiley & Sons Australia, Ltd</pub><pmid>30387311</pmid><doi>10.1111/imj.14106</doi><tpages>4</tpages><orcidid>https://orcid.org/0000-0001-5197-1163</orcidid></addata></record> |
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| ispartof | Internal medicine journal, 2018-11, Vol.48 (11), p.1392-1395 |
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| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adult Anti-Bacterial Agents - therapeutic use antibiotic Antibiotics Bacterial Infections - blood Bacterial Infections - drug therapy Biomarkers - blood C-Reactive Protein - metabolism Case-Control Studies Cystic fibrosis Cystic Fibrosis - blood Cystic Fibrosis - microbiology C‐reactive protein exacerbation Female Forced Expiratory Volume Humans Length of Stay Lung diseases Male Patients pneumonia Retrospective Studies Severity of Illness Index Tomography, X-Ray Computed Young Adult |
| title | C‐reactive protein levels in acute respiratory exacerbations of cystic fibrosis |
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