MiRNA‐199a‐5p positively regulated RANKL‐induced osteoclast differentiation by target Mafb protein

MicroRNAs are involved in osteoclast differentiation. Although miR‐199a‐5p plays an important role in many different systems and diseases, its function during osteoclastogenesis remains unclear. In this study, we investigated the function and the target gene of miR‐199a‐5p in osteoclast differentiat...

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Veröffentlicht in:	Journal of cellular biochemistry 2019-05, Vol.120 (5), p.7024-7031
Hauptverfasser:	Guo, Kai, Zhang, Dawei, Wu, Haining, Zhu, Qingsheng, Yang, Chongfei, Zhu, Jinyu
Format:	Artikel
Sprache:	eng
Schlagworte:	Acid phosphatase Acid phosphatase (tartrate-resistant) Acid resistance Biocompatibility Biomedical materials Chromosome 5 Differentiation Gene expression Lymphocytes Lymphocytes T Macrophages MAFB protein miRNA Mir‐199a‐5p nuclear factor of activated T‐cells cytoplasmic 1 (NFATc1) osteoclast Osteoclastogenesis Proteins receptor activator of nuclear factor kappa‐B ligand (RANKL) Ribonucleic acid RNA TRANCE protein Transfection
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