Dual influences of early life stress induced by limited bedding on walking adaptability and Bdnf/TrkB and Drd1/Drd2 gene expression in different mouse brain regions

•Exposure to early life stress leads to distinct walking adaptability phenotypes within the Limited Bedding (LB) group.•BDNF expression in the mPFC was increased in both the LB-IP and LB-SP subgroups.•A strong negative correlation was found between walking adaptability performance and BDNF exon IV i...

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Veröffentlicht in:	Behavioural brain research 2019-02, Vol.359, p.66-72
Hauptverfasser:	Wearick-Silva, L.E., Orso, R., Martins, L.A., Creutzberg, K.C., Centeno-Silva, A., Xavier, L.L., Grassi-Oliveira, R., Mestriner, R.G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptation, Physiological - physiology Adaptation, Psychological - physiology Animals Anxiety - physiopathology BDNF Brain - growth & development Brain - metabolism Brain-Derived Neurotrophic Factor - metabolism Dopamine Early life stress Gene Expression Regulation Male Membrane Glycoproteins - metabolism Mice, Inbred C57BL Models, Animal Phenotype Protein-Tyrosine Kinases - metabolism Receptors, Dopamine D1 - metabolism Receptors, Dopamine D2 - metabolism Stress, Psychological - physiopathology Walking - physiology Walking adaptability
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