Comparison of Inductively Coupled Plasma Atomic Emission Spectrometry and Inductively Coupled Plasma Mass Spectrometry With Quantitative Neutron Capture Radiography for the Determination of Boron in Biological Samples From Cancer Therapy
A boron-containing compound was administered to tumor-bearing mice and the time-dependent concentration was determined by ICP-AES, ICP-MS and quantitative neutron capture radiography (QNCR). The atomic spectrometric procedures were optimized to minimize analyte losses during microwave digestion. Non...
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| Veröffentlicht in: | Journal of analytical atomic spectrometry 1997, Vol.12 (10), p.1115-1122 |
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| container_title | Journal of analytical atomic spectrometry |
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| creator | Probst, Thomas U. Berryman, Natalia G. Lemmen, Peter Weissfloch, Lothar Auberger, Thomas Gabel, Detlev Carlsson, J rgen Larsson, B rje |
| description | A boron-containing compound was administered to tumor-bearing mice and the time-dependent concentration was determined by ICP-AES, ICP-MS and quantitative neutron capture radiography (QNCR). The atomic spectrometric procedures were optimized to minimize analyte losses during microwave digestion. Non-spectroscopic interferences were investigated in detail and appropriate internal standards were established for ICP-MS. The best detection limits achieved for boron were 30 ng ml super(-1) by ICP-AES and 0.3 ng ml super(-1) by ICP-MS. The respective determination limits in the digested and diluted tissue samples were 0.4 mu g ml super(-1) and 3 ng ml super(-1). The results of the spectrometric determinations were confirmed by QNCR of whole-body cryosections of six mice. A brief description of the metabolism of the boron compound is given. |
| doi_str_mv | 10.1039/a700445a |
| format | Article |
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The atomic spectrometric procedures were optimized to minimize analyte losses during microwave digestion. Non-spectroscopic interferences were investigated in detail and appropriate internal standards were established for ICP-MS. The best detection limits achieved for boron were 30 ng ml super(-1) by ICP-AES and 0.3 ng ml super(-1) by ICP-MS. The respective determination limits in the digested and diluted tissue samples were 0.4 mu g ml super(-1) and 3 ng ml super(-1). The results of the spectrometric determinations were confirmed by QNCR of whole-body cryosections of six mice. A brief description of the metabolism of the boron compound is given.</description><identifier>ISSN: 0267-9477</identifier><identifier>EISSN: 1364-5544</identifier><identifier>DOI: 10.1039/a700445a</identifier><language>eng</language><subject>Biological materials ; Boron ; Laser ablation ; Magnetic resonance imaging ; Metabolism ; Oncology ; Positron emission tomography ; Radiography ; Tissue</subject><ispartof>Journal of analytical atomic spectrometry, 1997, Vol.12 (10), p.1115-1122</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c276t-d920855a1d204c5f5b797a2a399ee2de690bfeb56833bfdc0a8b330ef9863b0b3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,2832,4025,27928,27929,27930</link.rule.ids></links><search><creatorcontrib>Probst, Thomas U.</creatorcontrib><creatorcontrib>Berryman, Natalia G.</creatorcontrib><creatorcontrib>Lemmen, Peter</creatorcontrib><creatorcontrib>Weissfloch, Lothar</creatorcontrib><creatorcontrib>Auberger, Thomas</creatorcontrib><creatorcontrib>Gabel, Detlev</creatorcontrib><creatorcontrib>Carlsson, J rgen</creatorcontrib><creatorcontrib>Larsson, B rje</creatorcontrib><title>Comparison of Inductively Coupled Plasma Atomic Emission Spectrometry and Inductively Coupled Plasma Mass Spectrometry With Quantitative Neutron Capture Radiography for the Determination of Boron in Biological Samples From Cancer Therapy</title><title>Journal of analytical atomic spectrometry</title><description>A boron-containing compound was administered to tumor-bearing mice and the time-dependent concentration was determined by ICP-AES, ICP-MS and quantitative neutron capture radiography (QNCR). The atomic spectrometric procedures were optimized to minimize analyte losses during microwave digestion. Non-spectroscopic interferences were investigated in detail and appropriate internal standards were established for ICP-MS. The best detection limits achieved for boron were 30 ng ml super(-1) by ICP-AES and 0.3 ng ml super(-1) by ICP-MS. The respective determination limits in the digested and diluted tissue samples were 0.4 mu g ml super(-1) and 3 ng ml super(-1). The results of the spectrometric determinations were confirmed by QNCR of whole-body cryosections of six mice. A brief description of the metabolism of the boron compound is given.</description><subject>Biological materials</subject><subject>Boron</subject><subject>Laser ablation</subject><subject>Magnetic resonance imaging</subject><subject>Metabolism</subject><subject>Oncology</subject><subject>Positron emission tomography</subject><subject>Radiography</subject><subject>Tissue</subject><issn>0267-9477</issn><issn>1364-5544</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><recordid>eNp9kc1u1TAQhS0EEpeCxCPMCrEJOHacn2Ub2lKpQEuLWEYTZ9JrlNjBdpDy0H0HfHVhwYbVLOZ854zmMPY65-9yLpv3WHFeFAqfsF0uyyJTqiiesh0XZZU1RVU9Zy9C-MGTSAm1Y4-tmxf0JjgLboQrO6w6ml80bdC6dZlogJsJw4xwGt1sNJzPJgST1HcL6ejdTNFvgHb4H_sJQ_gX-G7iHm5XtNFEPEDwmda0tdDiEldP8BUH4x48LvsNRuch7gk-UCQ_G5uI471n7oAYC2fGTe7BaJzgDueUHeAiZSU3q8nD_Z6S0_aSPRtxCvTqzzxh3y7O79uP2fWXy6v29DrToipjNjSC10phPgheaDWqvmoqFCibhkgMVDa8H6lXZS1lPw6aY91LyWls6lL2vJcn7M3Rd_Hu50ohdulrmqYJLbk1dCIXjaxLnoRvj0LtXQiexm7xZka_dTnvDn12f_uUvwEQZ5nl</recordid><startdate>1997</startdate><enddate>1997</enddate><creator>Probst, Thomas U.</creator><creator>Berryman, Natalia G.</creator><creator>Lemmen, Peter</creator><creator>Weissfloch, Lothar</creator><creator>Auberger, Thomas</creator><creator>Gabel, Detlev</creator><creator>Carlsson, J rgen</creator><creator>Larsson, B rje</creator><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>1997</creationdate><title>Comparison of Inductively Coupled Plasma Atomic Emission Spectrometry and Inductively Coupled Plasma Mass Spectrometry With Quantitative Neutron Capture Radiography for the Determination of Boron in Biological Samples From Cancer Therapy</title><author>Probst, Thomas U. ; Berryman, Natalia G. ; Lemmen, Peter ; Weissfloch, Lothar ; Auberger, Thomas ; Gabel, Detlev ; Carlsson, J rgen ; Larsson, B rje</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c276t-d920855a1d204c5f5b797a2a399ee2de690bfeb56833bfdc0a8b330ef9863b0b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Biological materials</topic><topic>Boron</topic><topic>Laser ablation</topic><topic>Magnetic resonance imaging</topic><topic>Metabolism</topic><topic>Oncology</topic><topic>Positron emission tomography</topic><topic>Radiography</topic><topic>Tissue</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Probst, Thomas U.</creatorcontrib><creatorcontrib>Berryman, Natalia G.</creatorcontrib><creatorcontrib>Lemmen, Peter</creatorcontrib><creatorcontrib>Weissfloch, Lothar</creatorcontrib><creatorcontrib>Auberger, Thomas</creatorcontrib><creatorcontrib>Gabel, Detlev</creatorcontrib><creatorcontrib>Carlsson, J rgen</creatorcontrib><creatorcontrib>Larsson, B rje</creatorcontrib><collection>CrossRef</collection><jtitle>Journal of analytical atomic spectrometry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Probst, Thomas U.</au><au>Berryman, Natalia G.</au><au>Lemmen, Peter</au><au>Weissfloch, Lothar</au><au>Auberger, Thomas</au><au>Gabel, Detlev</au><au>Carlsson, J rgen</au><au>Larsson, B rje</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of Inductively Coupled Plasma Atomic Emission Spectrometry and Inductively Coupled Plasma Mass Spectrometry With Quantitative Neutron Capture Radiography for the Determination of Boron in Biological Samples From Cancer Therapy</atitle><jtitle>Journal of analytical atomic spectrometry</jtitle><date>1997</date><risdate>1997</risdate><volume>12</volume><issue>10</issue><spage>1115</spage><epage>1122</epage><pages>1115-1122</pages><issn>0267-9477</issn><eissn>1364-5544</eissn><abstract>A boron-containing compound was administered to tumor-bearing mice and the time-dependent concentration was determined by ICP-AES, ICP-MS and quantitative neutron capture radiography (QNCR). The atomic spectrometric procedures were optimized to minimize analyte losses during microwave digestion. Non-spectroscopic interferences were investigated in detail and appropriate internal standards were established for ICP-MS. The best detection limits achieved for boron were 30 ng ml super(-1) by ICP-AES and 0.3 ng ml super(-1) by ICP-MS. The respective determination limits in the digested and diluted tissue samples were 0.4 mu g ml super(-1) and 3 ng ml super(-1). The results of the spectrometric determinations were confirmed by QNCR of whole-body cryosections of six mice. A brief description of the metabolism of the boron compound is given.</abstract><doi>10.1039/a700445a</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0267-9477 |
| ispartof | Journal of analytical atomic spectrometry, 1997, Vol.12 (10), p.1115-1122 |
| issn | 0267-9477 1364-5544 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_21293860 |
| source | Royal Society Of Chemistry Journals; Royal Society of Chemistry Journals Archive (1841-2007); Alma/SFX Local Collection |
| subjects | Biological materials Boron Laser ablation Magnetic resonance imaging Metabolism Oncology Positron emission tomography Radiography Tissue |
| title | Comparison of Inductively Coupled Plasma Atomic Emission Spectrometry and Inductively Coupled Plasma Mass Spectrometry With Quantitative Neutron Capture Radiography for the Determination of Boron in Biological Samples From Cancer Therapy |
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