Variability in PAH-DNA Adduct Measurements in Peripheral Mononuclear Cells: Implications for Quantitative Cancer Risk Assessment

Biomarkers such as DNA adducts have significant potential to improve quantitative risk assessment by characterizing individual differences in metabolism of genotoxins and DNA repair and accounting for some of the factors that could affect interindividual variation in cancer risk. Inherent uncertaint...

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Veröffentlicht in:	Risk analysis 1997-10, Vol.17 (5), p.649-656
Hauptverfasser:	Dickey, Christopher, Santella, Regina M., Hattis, Dale, Tang, Deliang, Hsu, Yanzhi, Cooper, Tom, Young, Tie-Lan, Perera, Frederica P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Analysis of Variance Aromatic hydrocarbons Cells DNA DNA Adducts - blood DNA Damage Female Health risks Humans Leukocytes, Mononuclear - metabolism Male Neoplasms - blood Neoplasms - etiology PAH-DNA adducts Polycyclic Aromatic Hydrocarbons - blood Reference Values Risk Assessment uncertainty variability
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