Morphofunctional characteristics of the rat distal spinal cord after its complete experimental transection with subsequent animal treadmill training
Motor activity of rats was studied after experimental complete transection of the spinal cord at lower thoracic level. Treadmill training 1 day after the surgery was shown to lead to the appearance of movements in hindlimbs and restoration of the body weight support function. According to our data,...
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| Veröffentlicht in: | Journal of evolutionary biochemistry and physiology 2008-12, Vol.44 (6), p.751-759 |
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| container_title | Journal of evolutionary biochemistry and physiology |
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| creator | Gilerovich, E. G Moshonkina, T. R Pavlova, N. V Fedorova, E. A Novikov, G. I Gerasimenko, Yu. P Otellin, V. A |
| description | Motor activity of rats was studied after experimental complete transection of the spinal cord at lower thoracic level. Treadmill training 1 day after the surgery was shown to lead to the appearance of movements in hindlimbs and restoration of the body weight support function. According to our data, the key moment in initiation of locomotor movements is stimulation of foot. Morphoimmunohistochemical investigation of the lumbar enlargement (study of proliferating cell nuclear protein, synaptophysin, and glial fibrillary acidic protein immunohistochemistry) revealed a rearrangement of motoneurons, interneurons, and the afferent chain in the distal part of the transected spinal cord. In the trained animals, there was observed the normal structure of motoneurons and the appearance of aggregates of the synaptophysin-immunoreactive structures lost after the surgery. |
| doi_str_mv | 10.1134/S0022093008060112 |
| format | Article |
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G ; Moshonkina, T. R ; Pavlova, N. V ; Fedorova, E. A ; Novikov, G. I ; Gerasimenko, Yu. P ; Otellin, V. A</creator><creatorcontrib>Gilerovich, E. G ; Moshonkina, T. R ; Pavlova, N. V ; Fedorova, E. A ; Novikov, G. I ; Gerasimenko, Yu. P ; Otellin, V. A</creatorcontrib><description>Motor activity of rats was studied after experimental complete transection of the spinal cord at lower thoracic level. Treadmill training 1 day after the surgery was shown to lead to the appearance of movements in hindlimbs and restoration of the body weight support function. According to our data, the key moment in initiation of locomotor movements is stimulation of foot. Morphoimmunohistochemical investigation of the lumbar enlargement (study of proliferating cell nuclear protein, synaptophysin, and glial fibrillary acidic protein immunohistochemistry) revealed a rearrangement of motoneurons, interneurons, and the afferent chain in the distal part of the transected spinal cord. 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Morphoimmunohistochemical investigation of the lumbar enlargement (study of proliferating cell nuclear protein, synaptophysin, and glial fibrillary acidic protein immunohistochemistry) revealed a rearrangement of motoneurons, interneurons, and the afferent chain in the distal part of the transected spinal cord. 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| subjects | Animal Physiology Biochemistry Biomedical and Life Sciences Evolutionary Biology Immunohistochemistry Life Sciences Morphological Basics for Evolution of Functions Motor ability Rehabilitation Rodents Spinal cord injuries |
| title | Morphofunctional characteristics of the rat distal spinal cord after its complete experimental transection with subsequent animal treadmill training |
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