Sensorimotor training and whole-body vibration training have the potential to reduce motor and sensory symptoms of chemotherapy-induced peripheral neuropathy—a randomized controlled pilot trial
Chemotherapy-induced peripheral neuropathy (CIPN) is a prevalent and clinically relevant side effect of chemotherapy. The symptoms diminish patients’ quality of life and represent a decisive limiting factor for medical therapy. To date, effective treatment options are lacking. Specific exercise inte...
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| Veröffentlicht in: | Supportive care in cancer 2019-07, Vol.27 (7), p.2471-2478 |
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| creator | Streckmann, Fiona Lehmann, H.C. Balke, M. Schenk, A. Oberste, M. Heller, A. Schürhörster, A. Elter, T. Bloch, W. Baumann, F.T. |
| description | Chemotherapy-induced peripheral neuropathy (CIPN) is a prevalent and clinically relevant side effect of chemotherapy. The symptoms diminish patients’ quality of life and represent a decisive limiting factor for medical therapy. To date, effective treatment options are lacking. Specific exercise interventions have proven promising to target relevant symptoms. We conducted a prospective, four-armed, randomized, controlled trial, to evaluate the effects of sensorimotor training (SMT) and whole-body vibration training (WBV) on patients with CIPN. Participants (
N
= 40) were randomized to either one of two intervention groups (SMT
N
= 10 or WBV
N
= 10) or oncological control group (
N
= 10) and matched by gender and age with a healthy control (
N
= 10). The intervention groups exercised twice a week for 6 weeks. Primary endpoint was the reduction of CIPN-related symptoms (improve peripheral deep sensitivity, Achilles tendon reflex (ASR) and patellar tendon reflex (PSR), light-touch perception, sense of position, and lower leg strength). Secondary endpoints were nerve conduction velocity and amplitude, balance control, quality of life, and CIPN-related pain. Patients exercising improved sensory and associated motor symptoms. Significant intergroup differences were found for the tendon reflexes (ASR
P
= .017 and PSR
P
= .020), peripheral deep sensitivity (
P
= .010), and pain (
P
= .043). Furthermore, tendencies were found regarding the subjective improvement of symptoms (
P
= .075) and two subscales of the EORTC-QLQ-C30 questionnaire: pain (
P
= .054) and dyspnea (
P
= .054). The results for the SMT group were superior regarding the tendon reflexes, and a tendency regarding the subjective report of symptoms, while WBV was superior regarding pain. SMT and WBV behold a large potential to reduce CIPN-related symptoms and can be considered feasible and safe for patients with CIPN (compliance 97.5%, no adverse events).
Registration: DRKS00013027 |
| doi_str_mv | 10.1007/s00520-018-4531-4 |
| format | Article |
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N
= 40) were randomized to either one of two intervention groups (SMT
N
= 10 or WBV
N
= 10) or oncological control group (
N
= 10) and matched by gender and age with a healthy control (
N
= 10). The intervention groups exercised twice a week for 6 weeks. Primary endpoint was the reduction of CIPN-related symptoms (improve peripheral deep sensitivity, Achilles tendon reflex (ASR) and patellar tendon reflex (PSR), light-touch perception, sense of position, and lower leg strength). Secondary endpoints were nerve conduction velocity and amplitude, balance control, quality of life, and CIPN-related pain. Patients exercising improved sensory and associated motor symptoms. Significant intergroup differences were found for the tendon reflexes (ASR
P
= .017 and PSR
P
= .020), peripheral deep sensitivity (
P
= .010), and pain (
P
= .043). Furthermore, tendencies were found regarding the subjective improvement of symptoms (
P
= .075) and two subscales of the EORTC-QLQ-C30 questionnaire: pain (
P
= .054) and dyspnea (
P
= .054). The results for the SMT group were superior regarding the tendon reflexes, and a tendency regarding the subjective report of symptoms, while WBV was superior regarding pain. SMT and WBV behold a large potential to reduce CIPN-related symptoms and can be considered feasible and safe for patients with CIPN (compliance 97.5%, no adverse events).
Registration: DRKS00013027</description><identifier>ISSN: 0941-4355</identifier><identifier>EISSN: 1433-7339</identifier><identifier>DOI: 10.1007/s00520-018-4531-4</identifier><identifier>PMID: 30382392</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Cancer ; Chemotherapy ; Evidence-based medicine ; Exercise ; Exercise therapy ; Medicine ; Medicine & Public Health ; Nursing ; Nursing Research ; Oncology ; Original Article ; Pain ; Pain Medicine ; Peripheral neuropathy ; Quality of life ; Rehabilitation Medicine</subject><ispartof>Supportive care in cancer, 2019-07, Vol.27 (7), p.2471-2478</ispartof><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2018</rights><rights>COPYRIGHT 2019 Springer</rights><rights>Supportive Care in Cancer is a copyright of Springer, (2018). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4204-a58ad813b95a4e9eb30728123e10e757146efe9bd1de48c796c7c024853909963</citedby><cites>FETCH-LOGICAL-c4204-a58ad813b95a4e9eb30728123e10e757146efe9bd1de48c796c7c024853909963</cites><orcidid>0000-0002-6023-033X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00520-018-4531-4$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00520-018-4531-4$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30382392$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Streckmann, Fiona</creatorcontrib><creatorcontrib>Lehmann, H.C.</creatorcontrib><creatorcontrib>Balke, M.</creatorcontrib><creatorcontrib>Schenk, A.</creatorcontrib><creatorcontrib>Oberste, M.</creatorcontrib><creatorcontrib>Heller, A.</creatorcontrib><creatorcontrib>Schürhörster, A.</creatorcontrib><creatorcontrib>Elter, T.</creatorcontrib><creatorcontrib>Bloch, W.</creatorcontrib><creatorcontrib>Baumann, F.T.</creatorcontrib><title>Sensorimotor training and whole-body vibration training have the potential to reduce motor and sensory symptoms of chemotherapy-induced peripheral neuropathy—a randomized controlled pilot trial</title><title>Supportive care in cancer</title><addtitle>Support Care Cancer</addtitle><addtitle>Support Care Cancer</addtitle><description>Chemotherapy-induced peripheral neuropathy (CIPN) is a prevalent and clinically relevant side effect of chemotherapy. The symptoms diminish patients’ quality of life and represent a decisive limiting factor for medical therapy. To date, effective treatment options are lacking. Specific exercise interventions have proven promising to target relevant symptoms. We conducted a prospective, four-armed, randomized, controlled trial, to evaluate the effects of sensorimotor training (SMT) and whole-body vibration training (WBV) on patients with CIPN. Participants (
N
= 40) were randomized to either one of two intervention groups (SMT
N
= 10 or WBV
N
= 10) or oncological control group (
N
= 10) and matched by gender and age with a healthy control (
N
= 10). The intervention groups exercised twice a week for 6 weeks. Primary endpoint was the reduction of CIPN-related symptoms (improve peripheral deep sensitivity, Achilles tendon reflex (ASR) and patellar tendon reflex (PSR), light-touch perception, sense of position, and lower leg strength). Secondary endpoints were nerve conduction velocity and amplitude, balance control, quality of life, and CIPN-related pain. Patients exercising improved sensory and associated motor symptoms. Significant intergroup differences were found for the tendon reflexes (ASR
P
= .017 and PSR
P
= .020), peripheral deep sensitivity (
P
= .010), and pain (
P
= .043). Furthermore, tendencies were found regarding the subjective improvement of symptoms (
P
= .075) and two subscales of the EORTC-QLQ-C30 questionnaire: pain (
P
= .054) and dyspnea (
P
= .054). The results for the SMT group were superior regarding the tendon reflexes, and a tendency regarding the subjective report of symptoms, while WBV was superior regarding pain. SMT and WBV behold a large potential to reduce CIPN-related symptoms and can be considered feasible and safe for patients with CIPN (compliance 97.5%, no adverse events).
Registration: DRKS00013027</description><subject>Cancer</subject><subject>Chemotherapy</subject><subject>Evidence-based medicine</subject><subject>Exercise</subject><subject>Exercise therapy</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Nursing</subject><subject>Nursing Research</subject><subject>Oncology</subject><subject>Original Article</subject><subject>Pain</subject><subject>Pain Medicine</subject><subject>Peripheral neuropathy</subject><subject>Quality of life</subject><subject>Rehabilitation Medicine</subject><issn>0941-4355</issn><issn>1433-7339</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNp1kk1u1TAUhSMEoo_CApggS0yYpPj3OR5WFX9SJQbA2HKSmxdXiR1sp1UYsQh2xE5YCU5TeAKBPLB0_Z1zr-1TFE8JPiMYy5cRY0FxiUlVcsFIye8VO8IZKyVj6n6xw4rnIhPipHgU4xXGREpBHxYnDLOKMkV3xfcP4KIPdvTJB5SCsc66AzKuRTe9H6Csfbuga1sHk6x3R6I314BSD2jyCVyyZkDJowDt3ADa3FaTeGu_oLiMU_JjRL5DTQ8Z6CGYaSmtWxUtmiDYaa0NyMEc_GRSv_z4-s2gkH38aL9kqPEuBT8MK28Hn_I4ufHj4kFnhghP7vbT4tPrVx8v3paX79-8uzi_LBtOMS-NqExbEVYrYTgoqBmWtCKUAcEghSR8Dx2ouiUt8KqRat_IBlNeCaawUnt2WrzYfKfgP88Qkx5tbGAYjAM_R00JlUrgPVcZff4XeuXn4PJ0t5RQmZJH6mAG0NZ1Pj9vs5rqc1FJUhEu1rZn_6DyamG0-UWgs7n-h4Bsgib4GAN0esofbMKiCdZrcPQWHJ2Do9fgaJ41z-4GnusR2t-KX0nJAN2AmI_cAcLxRv93_Qlwt9I-</recordid><startdate>20190701</startdate><enddate>20190701</enddate><creator>Streckmann, Fiona</creator><creator>Lehmann, H.C.</creator><creator>Balke, M.</creator><creator>Schenk, A.</creator><creator>Oberste, M.</creator><creator>Heller, A.</creator><creator>Schürhörster, A.</creator><creator>Elter, T.</creator><creator>Bloch, W.</creator><creator>Baumann, F.T.</creator><general>Springer Berlin Heidelberg</general><general>Springer</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0-V</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88J</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HEHIP</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2R</scope><scope>M2S</scope><scope>NAPCQ</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>POGQB</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PRQQA</scope><scope>Q9U</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-6023-033X</orcidid></search><sort><creationdate>20190701</creationdate><title>Sensorimotor training and whole-body vibration training have the potential to reduce motor and sensory symptoms of chemotherapy-induced peripheral neuropathy—a randomized controlled pilot trial</title><author>Streckmann, Fiona ; Lehmann, H.C. ; Balke, M. ; Schenk, A. ; Oberste, M. ; Heller, A. ; Schürhörster, A. ; Elter, T. ; Bloch, W. ; Baumann, F.T.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4204-a58ad813b95a4e9eb30728123e10e757146efe9bd1de48c796c7c024853909963</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Cancer</topic><topic>Chemotherapy</topic><topic>Evidence-based medicine</topic><topic>Exercise</topic><topic>Exercise therapy</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Nursing</topic><topic>Nursing Research</topic><topic>Oncology</topic><topic>Original Article</topic><topic>Pain</topic><topic>Pain Medicine</topic><topic>Peripheral neuropathy</topic><topic>Quality of life</topic><topic>Rehabilitation Medicine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Streckmann, Fiona</creatorcontrib><creatorcontrib>Lehmann, H.C.</creatorcontrib><creatorcontrib>Balke, M.</creatorcontrib><creatorcontrib>Schenk, A.</creatorcontrib><creatorcontrib>Oberste, M.</creatorcontrib><creatorcontrib>Heller, A.</creatorcontrib><creatorcontrib>Schürhörster, A.</creatorcontrib><creatorcontrib>Elter, T.</creatorcontrib><creatorcontrib>Bloch, W.</creatorcontrib><creatorcontrib>Baumann, F.T.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Social Sciences Premium Collection</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Social Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Social Science Premium Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Sociology Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Social Science Database</collection><collection>Sociology Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>ProQuest Health & Medical Research Collection</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest Sociology & Social Sciences Collection</collection><collection>ProQuest One Health & Nursing</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Social Sciences</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Supportive care in cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Streckmann, Fiona</au><au>Lehmann, H.C.</au><au>Balke, M.</au><au>Schenk, A.</au><au>Oberste, M.</au><au>Heller, A.</au><au>Schürhörster, A.</au><au>Elter, T.</au><au>Bloch, W.</au><au>Baumann, F.T.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sensorimotor training and whole-body vibration training have the potential to reduce motor and sensory symptoms of chemotherapy-induced peripheral neuropathy—a randomized controlled pilot trial</atitle><jtitle>Supportive care in cancer</jtitle><stitle>Support Care Cancer</stitle><addtitle>Support Care Cancer</addtitle><date>2019-07-01</date><risdate>2019</risdate><volume>27</volume><issue>7</issue><spage>2471</spage><epage>2478</epage><pages>2471-2478</pages><issn>0941-4355</issn><eissn>1433-7339</eissn><abstract>Chemotherapy-induced peripheral neuropathy (CIPN) is a prevalent and clinically relevant side effect of chemotherapy. The symptoms diminish patients’ quality of life and represent a decisive limiting factor for medical therapy. To date, effective treatment options are lacking. Specific exercise interventions have proven promising to target relevant symptoms. We conducted a prospective, four-armed, randomized, controlled trial, to evaluate the effects of sensorimotor training (SMT) and whole-body vibration training (WBV) on patients with CIPN. Participants (
N
= 40) were randomized to either one of two intervention groups (SMT
N
= 10 or WBV
N
= 10) or oncological control group (
N
= 10) and matched by gender and age with a healthy control (
N
= 10). The intervention groups exercised twice a week for 6 weeks. Primary endpoint was the reduction of CIPN-related symptoms (improve peripheral deep sensitivity, Achilles tendon reflex (ASR) and patellar tendon reflex (PSR), light-touch perception, sense of position, and lower leg strength). Secondary endpoints were nerve conduction velocity and amplitude, balance control, quality of life, and CIPN-related pain. Patients exercising improved sensory and associated motor symptoms. Significant intergroup differences were found for the tendon reflexes (ASR
P
= .017 and PSR
P
= .020), peripheral deep sensitivity (
P
= .010), and pain (
P
= .043). Furthermore, tendencies were found regarding the subjective improvement of symptoms (
P
= .075) and two subscales of the EORTC-QLQ-C30 questionnaire: pain (
P
= .054) and dyspnea (
P
= .054). The results for the SMT group were superior regarding the tendon reflexes, and a tendency regarding the subjective report of symptoms, while WBV was superior regarding pain. SMT and WBV behold a large potential to reduce CIPN-related symptoms and can be considered feasible and safe for patients with CIPN (compliance 97.5%, no adverse events).
Registration: DRKS00013027</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>30382392</pmid><doi>10.1007/s00520-018-4531-4</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-6023-033X</orcidid></addata></record> |
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| issn | 0941-4355 1433-7339 |
| language | eng |
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| source | SpringerLink Journals |
| subjects | Cancer Chemotherapy Evidence-based medicine Exercise Exercise therapy Medicine Medicine & Public Health Nursing Nursing Research Oncology Original Article Pain Pain Medicine Peripheral neuropathy Quality of life Rehabilitation Medicine |
| title | Sensorimotor training and whole-body vibration training have the potential to reduce motor and sensory symptoms of chemotherapy-induced peripheral neuropathy—a randomized controlled pilot trial |
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