Functional study of the 830C>G polymorphism of the human carboxylesterase 2 gene

Purpose Carboxylesterase 2 (CES2) is involved in the activation of the anticancer drug irinotecan to its active metabolite SN-38. We previously identified a single nucleotide polymorphism (SNP), with an allele frequency around 10%, as possibly involved in enzyme expression (Clin Pharmacol Ther 76:52...

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Veröffentlicht in:	Cancer chemotherapy and pharmacology 2008-03, Vol.61 (3), p.481-488
Hauptverfasser:	Bellott, Ricardo, Le Morvan, Valérie, Charasson, Virginie, Laurand, Armelle, Colotte, Marthe, Zanger, Ulrich M., Klein, Kathrin, Smith, Denis, Bonnet, Jacques, Robert, Jacques
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Amino Acid Substitution Antineoplastic agents Antineoplastic Agents, Phytogenic - pharmacokinetics Biological and medical sciences Camptothecin - analogs & derivatives Camptothecin - pharmacokinetics Cancer Research Carboxylesterase - genetics Cell Line, Tumor Colorectal Neoplasms - drug therapy Colorectal Neoplasms - genetics DNA - genetics Gastroenterology. Liver. Pancreas. Abdomen Genotype Humans Liver - chemistry Medical sciences Medicine Medicine & Public Health Oncology Original Article Paraffin Embedding Pharmacology. Drug treatments Pharmacology/Toxicology Polymorphism, Single Nucleotide - genetics Reverse Transcriptase Polymerase Chain Reaction Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Survival Analysis Tumors
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