Enhancing the Oral Absorption of Kinase Inhibitors Using Lipophilic Salts and Lipid-Based Formulations

The absolute bioavailability of many small molecule kinase inhibitors (smKIs) is low. The reasons for low bioavailability are multifaceted and include constraints due to first pass metabolism and poor absorption. For smKIs where absorption limits oral bioavailability, low aqueous solubility and high...

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Veröffentlicht in:	Molecular pharmaceutics 2018-12, Vol.15 (12), p.5678-5696
Hauptverfasser:	Williams, Hywel D., Ford, Leigh, Han, Sifei, Tangso, Kristian J., Lim, Shea, Shackleford, David M., Vodak, David T., Benameur, Hassan, Pouton, Colin W., Scammells, Peter J., Porter, Christopher J. H.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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