Stroke in HIV infection and AIDS
HIV/AIDS appears to increase the risk of both ischemic and hemorrhagic stroke. This increased risk is most apparent in the young HIV-infected population in which other risk factors for stroke are seldom evident. Mechanisms underlying the increased risk include opportunistic infectious meningitides a...
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Veröffentlicht in: | Expert review of cardiovascular therapy 2009-10, Vol.7 (10), p.1263-1271 |
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description | HIV/AIDS appears to increase the risk of both ischemic and hemorrhagic stroke. This increased risk is most apparent in the young HIV-infected population in which other risk factors for stroke are seldom evident. Mechanisms underlying the increased risk include opportunistic infectious meningitides and vasculitides, primary HIV vasculopathy, altered coagulation and cardioembolic events, although the cause may be multifactorial or remain cryptic. With better control of HIV via effective, highly active antiretroviral therapy, the role of many of these risks has been mitigated, only to be supplanted by an aging population with more conventional atherosclerotic risk factors magnified by the hyperlipidemia attending the use of protease inhibitors. Selecting the appropriate therapy for treating stroke in the HIV-infected patient is dependent on diagnostic rigor in identifying its underlying etiology. |
doi_str_mv | 10.1586/erc.09.72 |
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This increased risk is most apparent in the young HIV-infected population in which other risk factors for stroke are seldom evident. Mechanisms underlying the increased risk include opportunistic infectious meningitides and vasculitides, primary HIV vasculopathy, altered coagulation and cardioembolic events, although the cause may be multifactorial or remain cryptic. With better control of HIV via effective, highly active antiretroviral therapy, the role of many of these risks has been mitigated, only to be supplanted by an aging population with more conventional atherosclerotic risk factors magnified by the hyperlipidemia attending the use of protease inhibitors. Selecting the appropriate therapy for treating stroke in the HIV-infected patient is dependent on diagnostic rigor in identifying its underlying etiology.</description><subject>AIDS</subject><subject>AIDS (Disease)</subject><subject>Control</subject><subject>Development and progression</subject><subject>epidemiology</subject><subject>Highly active antiretroviral therapy</subject><subject>HIV</subject><subject>HIV (Viruses)</subject><subject>HIV patients</subject><subject>Human immunodeficiency virus</subject><subject>intracerebral hemorrhage</subject><subject>Protease inhibitors</subject><subject>Proteases</subject><subject>Risk factors</subject><subject>stroke</subject><subject>vasculopathy</subject><issn>1477-9072</issn><issn>1744-8344</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNptkEtLAzEQgIMoWKsH_8HiQfCwazbJbpJj8dVCwUPVa0izE7t1d1OTLdJ_b8p68EUgMyTfN8wMQuc5zvJClNfgTYZlxskBGuWcsVRQxg5jzjhPJebkGJ2EsMaYMlnQEUoWvXdvkNRdMp29xGDB9LXrEt1VyWR2uzhFR1Y3Ac6-4hg939893UzT-ePD7GYyTw0tSR9vRrA1RjDOhOHMCiP0EgjlBJMCikqbihZS5kusbQmUAK2YrgBEubR5_Bujy6Huxrv3LYRetXUw0DS6A7cNiuSEF5zQCF78Atdu67vYm8plUVJZch6hbIBedQMqTuV6r008FbS1cR3YOr5PCJVcCFbuhatBMN6F4MGqja9b7Xcqx2q_WRU3q7BUsYUxYgO7r-tb_eF8U6le7xrnrdedqYOi_2n0h7YC3fQroz18m-CP9QkqlY0U</recordid><startdate>20091001</startdate><enddate>20091001</enddate><creator>Dobbs, Michael R</creator><creator>Berger, Joseph R</creator><general>Informa Healthcare</general><general>Taylor & Francis</general><general>Expert Reviews Ltd</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7U9</scope><scope>H94</scope></search><sort><creationdate>20091001</creationdate><title>Stroke in HIV infection and AIDS</title><author>Dobbs, Michael R ; 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subjects | AIDS AIDS (Disease) Control Development and progression epidemiology Highly active antiretroviral therapy HIV HIV (Viruses) HIV patients Human immunodeficiency virus intracerebral hemorrhage Protease inhibitors Proteases Risk factors stroke vasculopathy |
title | Stroke in HIV infection and AIDS |
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