Efficacy of the novel parainfluenza virus haemagglutinin-neuraminidase inhibitor BCX 2798 in mice - further evaluation

Human parainfluenza virus type 1 (hPIV-1) causes serious respiratory tract infections, especially in children. This study investigated the efficacy of the novel haemagglutinin-neuraminidase (HN) inhibitor BCX 2798 in the prophylaxis of lethal and the treatment of non-lethal parainfluenza virus infec...

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Veröffentlicht in:	Antiviral therapy 2009-01, Vol.14 (7), p.891-898
Hauptverfasser:	ALYMOVA, Irina V, WATANABE, Makiko, BOYD, Kelli L, CHAND, Pooran, BABU, Ysudhakara, PORTNER, Allen
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Intranasal Animals Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents Azides - administration & dosage Azides - metabolism Biological and medical sciences Cell Line Dose-Response Relationship, Drug Enzyme Inhibitors - administration & dosage Enzyme Inhibitors - metabolism Female Hexuronic Acids - administration & dosage Hexuronic Acids - metabolism HN Protein - metabolism Humans Macaca mulatta Medical sciences Mice Parainfluenza virus Parainfluenza Virus 1, Human - drug effects Parainfluenza Virus 1, Human - metabolism Pharmacology. Drug treatments Premedication Respirovirus Infections - drug therapy Respirovirus Infections - metabolism Respirovirus Infections - virology Sendai virus Treatment Outcome
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