Diabetes regulates mitochondrial biogenesis and fission in mouse neurons

Aims/hypothesis Normal mitochondrial activity is a critical component of neuronal metabolism and function. Disruption of mitochondrial activity by altered mitochondrial fission and fusion is the root cause of both neurodegenerative disorders and Charcot-Marie-Tooth type 2A inherited neuropathy. This...

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Veröffentlicht in:	Diabetologia 2010, Vol.53 (1), p.160-169
Hauptverfasser:	Edwards, J. L, Quattrini, A, Lentz, S. I, Figueroa-Romero, C, Cerri, F, Backus, C, Hong, Y, Feldman, E. L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Regulatory Proteins - genetics Apoptosis Regulatory Proteins - metabolism Biological and medical sciences Biosynthesis Bromodeoxyuridine - metabolism Calcium-Calmodulin-Dependent Protein Kinases - genetics Calcium-Calmodulin-Dependent Protein Kinases - metabolism Cell Culture Techniques Cell Survival Death-Associated Protein Kinases Diabetes Diabetes Mellitus, Experimental - metabolism Diabetes Mellitus, Experimental - pathology Diabetes. Impaired glucose tolerance Diabetic neuropathy DNA, Mitochondrial - genetics DNA, Mitochondrial - metabolism Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Ganglia, Spinal - embryology Ganglia, Spinal - pathology Gene Expression Regulation Glutamine - pharmacology Glycated Hemoglobin - metabolism GTP Phosphohydrolases - genetics Human Physiology Hyperglycemia Hypotheses Internal Medicine Medical sciences Medicine Medicine & Public Health Metabolic Diseases Metabolism Mice MicroRNAs - genetics Mitochondria Mitochondria - metabolism Mitochondria - pathology Mitochondria - ultrastructure Mitochondrial DNA Neural networks Neurons - cytology Oxidative Stress Pathogenesis Proteins
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