Tumor specific cytotoxicity of β-glucosylceramide: structure-cytotoxicity relationship and anti-tumor activity in vivo

This study describes the structure-cytotoxicity relationship of β-glucosylceramide (β-GluCer) and its antitumor activity in vivo. Unglycosylated ceramide had no selective cytotoxicity which demonstrated that the sugar moiety plays a critical role for the expression of selective cytotoxicity by β-Glu...

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Veröffentlicht in:	Cancer chemotherapy and pharmacology 2009-07, Vol.64 (3), p.485-496
Hauptverfasser:	Oku, Hirosuke, Li, Changchun, Shimatani, Masayuki, Iwasaki, Hironori, Toda, Takayoshi, Okabe, Takafumi, Watanabe, Hisami
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents Antineoplastic Agents - pharmacology Biological and medical sciences Cancer Research Cell Cycle - drug effects Cell Line, Tumor Drug Screening Assays, Antitumor Glucosylceramides - pharmacology Humans Hydrophobic and Hydrophilic Interactions Injections, Intraperitoneal Lymphoma - drug therapy Lymphoma - pathology Male Medical sciences Medicine Medicine & Public Health Mice Mice, Inbred C3H Mice, Inbred C57BL Natural Killer T-Cells - drug effects Natural Killer T-Cells - metabolism Necrosis - pathology Neoplasm Metastasis - drug therapy Neoplasm Transplantation Neoplasms - drug therapy Neoplasms - pathology Oncology Original Article Pharmacology. Drug treatments Pharmacology/Toxicology Reactive Oxygen Species - metabolism Structure-Activity Relationship
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