Near-Infrared Fluorescent Probes for Hypoxia Detection via Joint Regulated Enzymes: Design, Synthesis, and Application in Living Cells and Mice

Hypoxia detection is emphasized with attention due to tumor and related diseases diagnosis, which could provide useful methods for exploring the mechanism of hypoxic tumor. Herein, we report two unprecedented hypoxia-sensitive probes that specifically switch-on their near-infrared fluorescence signa...

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Veröffentlicht in:	Analytical chemistry (Washington) 2018-11, Vol.90 (22), p.13759-13766
Hauptverfasser:	Tian, Xinwei, Li, Zhao, Sun, Yue, Wang, Pan, Ma, Huimin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cancer Cell Line, Tumor Chemistry Cytochrome Cytochrome P450 Cytochromes P450 Cytotoxicity Damage accumulation Diagnosis Enzymes Enzymes - metabolism Female Fluorescence Fluorescent Dyes - chemistry Fluorescent indicators Hypoxia Hypoxia - diagnosis I.R. radiation Infrared imaging systems Joints - metabolism Medical diagnosis Mice Mice, Inbred BALB C NADPH-ferrihemoprotein reductase Near infrared radiation Nitroreductase Probes Selectivity Sensors Spectrum Analysis - methods Toxicity Tumors
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