Ameliorative effects of a fusion protein dual targeting interleukin 17A and tumor necrosis factor α on imiquimod-induced psoriasis in mice

[Display omitted] •DTF could target IL-17 A and TNF-α simultaneously.•DTF treatment significantly attenuated IMQ-induced psoriasis in mice.•DTF was more potent than etanercept in ameliorating IMQ-induced psoriasis.•DTF reduced the expression of keratins in psoriasis-like skin in mice.•DTF enhanced t...

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Veröffentlicht in:	Biomedicine & pharmacotherapy 2018-12, Vol.108, p.1425-1434
Hauptverfasser:	Liu, Zhihang, Liu, Han, Xu, Pengfei, Yin, Qi, Wang, Yaoqun, Opoku, Yeboah Kwaku, Yang, Jiarui, Song, Liying, Sun, Xu, Zhang, Teng, Yu, Dan, Wang, Xiangxiang, Ren, Guiping, Li, Deshan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, Ly - genetics Caspase 14 - genetics Dual targeting fusion protein Etanercept - therapeutic use Female Imiquimod - toxicity Imiquimod-induced psoriasis Inflammation Interleukin 17A Interleukin-17 - antagonists & inhibitors Intermediate Filament Proteins - genetics Keratin-16 - analysis Keratin-17 - analysis Keratin-6 - analysis Mice Mice, Inbred BALB C Psoriasis - chemically induced Psoriasis - drug therapy Tumor necrosis factor α Tumor Necrosis Factor-alpha - antagonists & inhibitors
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