Phase I Evaluation of Oral and Intravenous Vinorelbine in Pediatric Cancer Patients: A Report from the Children's Oncology Group

Purpose: Vinorelbine (Navelbine) is an orally absorbable Vinca with broad antitumor activity. It differs from other Vinca in that it is structurally modified on the catharanthine nucleus and has differential actions on tubulin that render it less neurotoxic than other compounds in this class. We con...

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Veröffentlicht in:	Clinical cancer research 2006-01, Vol.12 (2), p.516-522
Hauptverfasser:	JOHANSEN, Mary, KUTTESCH, John, BLEYER, W. Archie, KRAILO, Mark, AMES, Matthew, MADDEN, Timothy
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Adolescent alkaloids Antineoplastic agents Antineoplastic Agents - administration & dosage Antineoplastic Agents - adverse effects Antineoplastic Agents - pharmacokinetics Area Under Curve Biological and medical sciences Biological Availability Bone Neoplasms - drug therapy Bone Neoplasms - metabolism cancer Capsules Central Nervous System Neoplasms - drug therapy Central Nervous System Neoplasms - metabolism Child Child, Preschool children Female Gelatin Humans Infusions, Intravenous Male Maximum Tolerated Dose Medical sciences Navelbine oral pediatric pharmacokinetics Pharmacology. Drug treatments Sarcoma - drug therapy Sarcoma - metabolism toxicity Vinblastine - administration & dosage Vinblastine - adverse effects Vinblastine - analogs & derivatives Vinblastine - pharmacokinetics Vinca vinorelbine
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