Honey can help in herpes simplex gingivostomatitis in children: Prospective randomized double blind placebo controlled clinical trial
Herpes simplex gingivostomatitis (HSGS) in children is a common painful infectious disease. This study aims to examine the combined efficacy of honey with acyclovir suspension compared to acyclovir alone for treating HSGS in young children. This Randomized double blind placebo controlled study was c...
Gespeichert in:
| Veröffentlicht in: | American journal of otolaryngology 2018-11, Vol.39 (6), p.759-763 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 763 |
|---|---|
| container_issue | 6 |
| container_start_page | 759 |
| container_title | American journal of otolaryngology |
| container_volume | 39 |
| creator | Abdel-Naby Awad, Osama G. Hamad, Abdel-Monem H. |
| description | Herpes simplex gingivostomatitis (HSGS) in children is a common painful infectious disease. This study aims to examine the combined efficacy of honey with acyclovir suspension compared to acyclovir alone for treating HSGS in young children.
This Randomized double blind placebo controlled study was conducted from June 2015 to September 2017 in a tertiary referral hospital. One hundred children aged 2–8 years with HSGS were randomly classified into 2 groups; study group: treated with honey plus oral acyclovir and control group: treated with oral acyclovir alone. Severity of oral lesions, Fever, eating and drinking ability, pain scores and need for analgesics were compared between 2 groups on day 3, 5 and 7 after starting treatment.
Children receiving honey plus acyclovir (i.e. study group) had significantly earlier disappearance of herpetic oral lesions; median 3 days vs. 6 days in control group (P = 0.022), drooling; 2 days vs. 4 days (P = 0.030) and eating difficulty; 3 days vs. 8 days (P = 0.001). Study group also had significantly lower pain scores, better eating and drinking ability and significantly less need for analgesics at 3 time-points of assessment. Fever disappeared in both groups with no statistically significant difference.
The combined use of honey with oral acyclovir can produce favorable outcome than acyclovir alone in children with Primary herpetic gingivostomatitis. |
| doi_str_mv | 10.1016/j.amjoto.2018.09.007 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2126918221</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0196070918305817</els_id><sourcerecordid>2124430418</sourcerecordid><originalsourceid>FETCH-LOGICAL-c390t-d415843f2975495aa5d5b0d8c9cca6cebcf106930424b1d6f87b679bf96d8c6f3</originalsourceid><addsrcrecordid>eNp9kUGL1TAUhYMoznP0H4gE3LhpTdI2bVwIw6COMKALBXchTW5nUtKkJunDce__NuWNLly4uov7nXsu5yD0nJKaEspfz7Va5pBDzQgdaiJqQvoH6EC7hlUDHb49RAdCBa9IT8QZepLSTAhp2qZ7jM4awlgvuDigX1fBwx3WyuNbcCu2-4wrJJzssjr4gW-sv7HHkHJYVLbZpp3Rt9aZCP4N_hxDWkFnewQclTdhsT_BYBO20QEenfUGr05pGAPWwecYnCt7XRZWK4dztMo9RY8m5RI8u5_n6Ov7d18ur6rrTx8-Xl5cV7oRJFempd3QNhMTfdeKTqnOdCMxgxZaK14s9EQJFw1pWTtSw6ehH3kvxknwAvGpOUevTnfXGL5vkLJcbNLgnPIQtiQZZVzQgTFa0Jf_oHPYoi_f7VTbFhM6FKo9UbrEkCJMco12UfFOUiL3muQsTzXJvSZJhCw1FdmL--PbuID5K_rTSwHengAoaRwtRJm0Ba_B2FjClibY_zv8BtlNqDw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2124430418</pqid></control><display><type>article</type><title>Honey can help in herpes simplex gingivostomatitis in children: Prospective randomized double blind placebo controlled clinical trial</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Abdel-Naby Awad, Osama G. ; Hamad, Abdel-Monem H.</creator><creatorcontrib>Abdel-Naby Awad, Osama G. ; Hamad, Abdel-Monem H.</creatorcontrib><description>Herpes simplex gingivostomatitis (HSGS) in children is a common painful infectious disease. This study aims to examine the combined efficacy of honey with acyclovir suspension compared to acyclovir alone for treating HSGS in young children.
This Randomized double blind placebo controlled study was conducted from June 2015 to September 2017 in a tertiary referral hospital. One hundred children aged 2–8 years with HSGS were randomly classified into 2 groups; study group: treated with honey plus oral acyclovir and control group: treated with oral acyclovir alone. Severity of oral lesions, Fever, eating and drinking ability, pain scores and need for analgesics were compared between 2 groups on day 3, 5 and 7 after starting treatment.
Children receiving honey plus acyclovir (i.e. study group) had significantly earlier disappearance of herpetic oral lesions; median 3 days vs. 6 days in control group (P = 0.022), drooling; 2 days vs. 4 days (P = 0.030) and eating difficulty; 3 days vs. 8 days (P = 0.001). Study group also had significantly lower pain scores, better eating and drinking ability and significantly less need for analgesics at 3 time-points of assessment. Fever disappeared in both groups with no statistically significant difference.
The combined use of honey with oral acyclovir can produce favorable outcome than acyclovir alone in children with Primary herpetic gingivostomatitis.</description><identifier>ISSN: 0196-0709</identifier><identifier>EISSN: 1532-818X</identifier><identifier>DOI: 10.1016/j.amjoto.2018.09.007</identifier><identifier>PMID: 30227969</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Acyclovir ; Acyclovir - therapeutic use ; Administration, Oral ; Age ; Analgesics ; Antiviral Agents - therapeutic use ; Apitherapy ; Child ; Child, Preschool ; Children ; Clinical trials ; Combined Modality Therapy ; Double-Blind Method ; Double-blind studies ; Drug dosages ; Eating ; Evidence-based medicine ; Female ; Fever ; Gingivostomatitis ; Herpes simplex ; Herpes viruses ; Honey ; Humans ; Infectious diseases ; Inflammation ; Lesions ; Male ; Nonsteroidal anti-inflammatory drugs ; Pain ; Parents & parenting ; Patients ; Pharmaceutical industry ; Prospective Studies ; Randomization ; Saliva ; Statistical analysis ; Stomatitis, Herpetic - therapy ; Treatment Outcome</subject><ispartof>American journal of otolaryngology, 2018-11, Vol.39 (6), p.759-763</ispartof><rights>2018 Elsevier Inc.</rights><rights>Copyright © 2018 Elsevier Inc. All rights reserved.</rights><rights>Copyright Elsevier Limited Nov 2018</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c390t-d415843f2975495aa5d5b0d8c9cca6cebcf106930424b1d6f87b679bf96d8c6f3</citedby><cites>FETCH-LOGICAL-c390t-d415843f2975495aa5d5b0d8c9cca6cebcf106930424b1d6f87b679bf96d8c6f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0196070918305817$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30227969$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Abdel-Naby Awad, Osama G.</creatorcontrib><creatorcontrib>Hamad, Abdel-Monem H.</creatorcontrib><title>Honey can help in herpes simplex gingivostomatitis in children: Prospective randomized double blind placebo controlled clinical trial</title><title>American journal of otolaryngology</title><addtitle>Am J Otolaryngol</addtitle><description>Herpes simplex gingivostomatitis (HSGS) in children is a common painful infectious disease. This study aims to examine the combined efficacy of honey with acyclovir suspension compared to acyclovir alone for treating HSGS in young children.
This Randomized double blind placebo controlled study was conducted from June 2015 to September 2017 in a tertiary referral hospital. One hundred children aged 2–8 years with HSGS were randomly classified into 2 groups; study group: treated with honey plus oral acyclovir and control group: treated with oral acyclovir alone. Severity of oral lesions, Fever, eating and drinking ability, pain scores and need for analgesics were compared between 2 groups on day 3, 5 and 7 after starting treatment.
Children receiving honey plus acyclovir (i.e. study group) had significantly earlier disappearance of herpetic oral lesions; median 3 days vs. 6 days in control group (P = 0.022), drooling; 2 days vs. 4 days (P = 0.030) and eating difficulty; 3 days vs. 8 days (P = 0.001). Study group also had significantly lower pain scores, better eating and drinking ability and significantly less need for analgesics at 3 time-points of assessment. Fever disappeared in both groups with no statistically significant difference.
The combined use of honey with oral acyclovir can produce favorable outcome than acyclovir alone in children with Primary herpetic gingivostomatitis.</description><subject>Acyclovir</subject><subject>Acyclovir - therapeutic use</subject><subject>Administration, Oral</subject><subject>Age</subject><subject>Analgesics</subject><subject>Antiviral Agents - therapeutic use</subject><subject>Apitherapy</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Children</subject><subject>Clinical trials</subject><subject>Combined Modality Therapy</subject><subject>Double-Blind Method</subject><subject>Double-blind studies</subject><subject>Drug dosages</subject><subject>Eating</subject><subject>Evidence-based medicine</subject><subject>Female</subject><subject>Fever</subject><subject>Gingivostomatitis</subject><subject>Herpes simplex</subject><subject>Herpes viruses</subject><subject>Honey</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Inflammation</subject><subject>Lesions</subject><subject>Male</subject><subject>Nonsteroidal anti-inflammatory drugs</subject><subject>Pain</subject><subject>Parents & parenting</subject><subject>Patients</subject><subject>Pharmaceutical industry</subject><subject>Prospective Studies</subject><subject>Randomization</subject><subject>Saliva</subject><subject>Statistical analysis</subject><subject>Stomatitis, Herpetic - therapy</subject><subject>Treatment Outcome</subject><issn>0196-0709</issn><issn>1532-818X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kUGL1TAUhYMoznP0H4gE3LhpTdI2bVwIw6COMKALBXchTW5nUtKkJunDce__NuWNLly4uov7nXsu5yD0nJKaEspfz7Va5pBDzQgdaiJqQvoH6EC7hlUDHb49RAdCBa9IT8QZepLSTAhp2qZ7jM4awlgvuDigX1fBwx3WyuNbcCu2-4wrJJzssjr4gW-sv7HHkHJYVLbZpp3Rt9aZCP4N_hxDWkFnewQclTdhsT_BYBO20QEenfUGr05pGAPWwecYnCt7XRZWK4dztMo9RY8m5RI8u5_n6Ov7d18ur6rrTx8-Xl5cV7oRJFempd3QNhMTfdeKTqnOdCMxgxZaK14s9EQJFw1pWTtSw6ehH3kvxknwAvGpOUevTnfXGL5vkLJcbNLgnPIQtiQZZVzQgTFa0Jf_oHPYoi_f7VTbFhM6FKo9UbrEkCJMco12UfFOUiL3muQsTzXJvSZJhCw1FdmL--PbuID5K_rTSwHengAoaRwtRJm0Ba_B2FjClibY_zv8BtlNqDw</recordid><startdate>201811</startdate><enddate>201811</enddate><creator>Abdel-Naby Awad, Osama G.</creator><creator>Hamad, Abdel-Monem H.</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7QR</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>201811</creationdate><title>Honey can help in herpes simplex gingivostomatitis in children: Prospective randomized double blind placebo controlled clinical trial</title><author>Abdel-Naby Awad, Osama G. ; Hamad, Abdel-Monem H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c390t-d415843f2975495aa5d5b0d8c9cca6cebcf106930424b1d6f87b679bf96d8c6f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Acyclovir</topic><topic>Acyclovir - therapeutic use</topic><topic>Administration, Oral</topic><topic>Age</topic><topic>Analgesics</topic><topic>Antiviral Agents - therapeutic use</topic><topic>Apitherapy</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Children</topic><topic>Clinical trials</topic><topic>Combined Modality Therapy</topic><topic>Double-Blind Method</topic><topic>Double-blind studies</topic><topic>Drug dosages</topic><topic>Eating</topic><topic>Evidence-based medicine</topic><topic>Female</topic><topic>Fever</topic><topic>Gingivostomatitis</topic><topic>Herpes simplex</topic><topic>Herpes viruses</topic><topic>Honey</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Inflammation</topic><topic>Lesions</topic><topic>Male</topic><topic>Nonsteroidal anti-inflammatory drugs</topic><topic>Pain</topic><topic>Parents & parenting</topic><topic>Patients</topic><topic>Pharmaceutical industry</topic><topic>Prospective Studies</topic><topic>Randomization</topic><topic>Saliva</topic><topic>Statistical analysis</topic><topic>Stomatitis, Herpetic - therapy</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Abdel-Naby Awad, Osama G.</creatorcontrib><creatorcontrib>Hamad, Abdel-Monem H.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of otolaryngology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Abdel-Naby Awad, Osama G.</au><au>Hamad, Abdel-Monem H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Honey can help in herpes simplex gingivostomatitis in children: Prospective randomized double blind placebo controlled clinical trial</atitle><jtitle>American journal of otolaryngology</jtitle><addtitle>Am J Otolaryngol</addtitle><date>2018-11</date><risdate>2018</risdate><volume>39</volume><issue>6</issue><spage>759</spage><epage>763</epage><pages>759-763</pages><issn>0196-0709</issn><eissn>1532-818X</eissn><abstract>Herpes simplex gingivostomatitis (HSGS) in children is a common painful infectious disease. This study aims to examine the combined efficacy of honey with acyclovir suspension compared to acyclovir alone for treating HSGS in young children.
This Randomized double blind placebo controlled study was conducted from June 2015 to September 2017 in a tertiary referral hospital. One hundred children aged 2–8 years with HSGS were randomly classified into 2 groups; study group: treated with honey plus oral acyclovir and control group: treated with oral acyclovir alone. Severity of oral lesions, Fever, eating and drinking ability, pain scores and need for analgesics were compared between 2 groups on day 3, 5 and 7 after starting treatment.
Children receiving honey plus acyclovir (i.e. study group) had significantly earlier disappearance of herpetic oral lesions; median 3 days vs. 6 days in control group (P = 0.022), drooling; 2 days vs. 4 days (P = 0.030) and eating difficulty; 3 days vs. 8 days (P = 0.001). Study group also had significantly lower pain scores, better eating and drinking ability and significantly less need for analgesics at 3 time-points of assessment. Fever disappeared in both groups with no statistically significant difference.
The combined use of honey with oral acyclovir can produce favorable outcome than acyclovir alone in children with Primary herpetic gingivostomatitis.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>30227969</pmid><doi>10.1016/j.amjoto.2018.09.007</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0196-0709 |
| ispartof | American journal of otolaryngology, 2018-11, Vol.39 (6), p.759-763 |
| issn | 0196-0709 1532-818X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2126918221 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Acyclovir Acyclovir - therapeutic use Administration, Oral Age Analgesics Antiviral Agents - therapeutic use Apitherapy Child Child, Preschool Children Clinical trials Combined Modality Therapy Double-Blind Method Double-blind studies Drug dosages Eating Evidence-based medicine Female Fever Gingivostomatitis Herpes simplex Herpes viruses Honey Humans Infectious diseases Inflammation Lesions Male Nonsteroidal anti-inflammatory drugs Pain Parents & parenting Patients Pharmaceutical industry Prospective Studies Randomization Saliva Statistical analysis Stomatitis, Herpetic - therapy Treatment Outcome |
| title | Honey can help in herpes simplex gingivostomatitis in children: Prospective randomized double blind placebo controlled clinical trial |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-05T07%3A38%3A07IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Honey%20can%20help%20in%20herpes%20simplex%20gingivostomatitis%20in%20children:%20Prospective%20randomized%20double%20blind%20placebo%20controlled%20clinical%20trial&rft.jtitle=American%20journal%20of%20otolaryngology&rft.au=Abdel-Naby%20Awad,%20Osama%20G.&rft.date=2018-11&rft.volume=39&rft.issue=6&rft.spage=759&rft.epage=763&rft.pages=759-763&rft.issn=0196-0709&rft.eissn=1532-818X&rft_id=info:doi/10.1016/j.amjoto.2018.09.007&rft_dat=%3Cproquest_cross%3E2124430418%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2124430418&rft_id=info:pmid/30227969&rft_els_id=S0196070918305817&rfr_iscdi=true |