Hydroxytyrosol from olive fruits prevents blue‐light‐induced damage in human keratinocytes and fibroblasts

Skin aging is a complex biological process influenced by a combination of endogenous or intrinsic and exogenous or extrinsic factors due to environmental damage. The primary environmental factor that causes human skin aging is the ultraviolet irradiation from the sun. Recently, it was established th...

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Veröffentlicht in:	Journal of cellular physiology 2019-06, Vol.234 (6), p.9065-9076
Hauptverfasser:	Avola, Rosanna, Graziano, Adriana Carol Eleonora, Pannuzzo, Giovanna, Bonina, Francesco, Cardile, Venera
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Antioxidants Antioxidants - isolation & purification Antioxidants - pharmacology Biological activity blue light cell culture Cell Line Cell Survival - drug effects Cell Survival - radiation effects Chemical synthesis Collagen Collagen (type I) Collagen Type I - genetics Collagen Type I - metabolism Collagenase Deoxyguanosine Deoxyribonucleic acid DNA DNA Damage Elastase Elastin Elastin - metabolism Electronic devices Electronic equipment Environmental degradation Environmental factors Extracellular matrix Fibroblasts Fibroblasts - drug effects Fibroblasts - metabolism Fibroblasts - pathology Fibroblasts - radiation effects Fruit - chemistry Fruits Humans Irradiation Keratinocytes Keratinocytes - drug effects Keratinocytes - metabolism Keratinocytes - pathology Keratinocytes - radiation effects Light - adverse effects Light emitting diodes Matrix metalloproteinase Matrix Metalloproteinase 1 - genetics Matrix Metalloproteinase 1 - metabolism Matrix Metalloproteinase 12 - genetics Matrix Metalloproteinase 12 - metabolism Metalloproteinase Molecular modelling Olea - chemistry Oxidative stress Oxidative Stress - drug effects Oxidative Stress - radiation effects Phenylethyl Alcohol - analogs & derivatives Phenylethyl Alcohol - isolation & purification Phenylethyl Alcohol - pharmacology photoaging Prevention Proliferating cell nuclear antigen Proliferating Cell Nuclear Antigen - metabolism Radiation-Protective Agents - isolation & purification Radiation-Protective Agents - pharmacology Reactive oxygen species Reactive Oxygen Species - metabolism Skin Skin - drug effects Skin - metabolism Skin - pathology Skin - radiation effects Skin Aging - drug effects Skin Aging - radiation effects Structural damage Time Factors Ultraviolet radiation
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