Omega‐3 fatty acids regulate plasticity in distinct hippocampal glutamatergic synapses

Dietary omega‐3 fatty acids accumulate and are actively retained in central nervous system membranes, mainly in synapses, dendrites and photoreceptors. Despite this selective enrichment, their impact on synaptic function and plasticity has not been fully determined at the molecular level. In this st...

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Veröffentlicht in:	The European journal of neuroscience 2019-01, Vol.49 (1), p.40-50
Hauptverfasser:	Aryal, Sanjay, Hussain, Suleman, Drevon, Christian A., Nagelhus, Erlend, Hvalby, Øyvind, Jensen, Vidar, Walaas, Sven Ivar, Davanger, Svend
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Central nervous system Dendrites Docosahexaenoic acid Dopamine - metabolism Dopamine receptors Excitatory Postsynaptic Potentials Fatty acids Fatty Acids, Omega-3 - administration & dosage Female glutamate receptors Glutamatergic transmission Glutamic acid receptors Hippocampal plasticity Hippocampus Hippocampus - drug effects Hippocampus - metabolism Hippocampus - physiology Inositol 1,4,5-trisphosphate receptors IP3‐R Long-term potentiation Long-Term Potentiation - drug effects LTP Male Mice, Inbred C57BL omega‐3 fatty acids Phospholipids Photoreceptors Receptors, Glutamate - physiology Serotonin - metabolism Stratum radiatum Synapses - drug effects Synapses - physiology Synaptic plasticity Synaptophysin Synaptosomes Synaptosomes - metabolism Synaptotagmin Weaning
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