Dose-Volume Parameters Predict Radiation Pneumonitis after Surgery with Induction Concurrent Chemoradiotherapy for Non-small Cell Lung Cancer
To clarify the relationship between dose-volume histogram (DVH) parameters and radiation pneumonitis (RP) after surgery in cases of non-small cell lung cancer (NSCLC) treated with induction concurrent chemoradiotherapy (CCRT). Patients with NSCLC treated with induction CCRT (chemotherapy: cisplatin...
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| Veröffentlicht in: | Acta medica Okayama 2018-10, Vol.72 (5), p.507-513 |
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| creator | Ogata, Takeshi Katsui, Kuniaki Yoshio, Kotaro Ihara, Hiroki Katayama, Norihisa Soh, Junichi Kuroda, Masahiro Kiura, Katsuyuki Maeda, Yoshinobu Toyooka, Shinichi Kanazawa, Susumu |
| description | To clarify the relationship between dose-volume histogram (DVH) parameters and radiation pneumonitis (RP) after surgery in cases of non-small cell lung cancer (NSCLC) treated with induction concurrent chemoradiotherapy (CCRT). Patients with NSCLC treated with induction CCRT (chemotherapy: cisplatin and docetaxel; radiotherapy: 2.0 Gy fractions once daily for a total of 46 Gy) before surgery were reviewed. We calculated the percentage of lung volume receiving at least 20 Gy (V20) and the mean lung dose (MLD) for the total lung volume and the lung remaining after resection. Factors affecting the incidence of RP at grade 2 or higher (≥ G2 RP) were analyzed. Eighteen of 49 patients (37%) experienced ≥G2 RP. The V20 and MLD for the lung remaining after resection (V20r and MLDr) were significant predictors according to the multivariate analysis (p=0.007 and 0.041, respectively). The incidence of ≥G2 RP was 8% in patients with V20r |
| doi_str_mv | 10.18926/AMO/56249 |
| format | Article |
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Patients with NSCLC treated with induction CCRT (chemotherapy: cisplatin and docetaxel; radiotherapy: 2.0 Gy fractions once daily for a total of 46 Gy) before surgery were reviewed. We calculated the percentage of lung volume receiving at least 20 Gy (V20) and the mean lung dose (MLD) for the total lung volume and the lung remaining after resection. Factors affecting the incidence of RP at grade 2 or higher (≥ G2 RP) were analyzed. Eighteen of 49 patients (37%) experienced ≥G2 RP. The V20 and MLD for the lung remaining after resection (V20r and MLDr) were significant predictors according to the multivariate analysis (p=0.007 and 0.041, respectively). The incidence of ≥G2 RP was 8% in patients with V20r<10%, and 13% in patients with MLDr<5.6 Gy, respectively. The optimal approach to reduce the rate of postoperative RP in patients with induction CCRT for NSCLC is to keep the V20r below 10% and/or the MLDr below 5.6 Gy in the radiotherapy planning.</description><identifier>ISSN: 0386-300X</identifier><identifier>DOI: 10.18926/AMO/56249</identifier><identifier>PMID: 30369608</identifier><language>eng</language><publisher>Japan</publisher><subject>Aged ; Carcinoma, Non-Small-Cell Lung - therapy ; Chemoradiotherapy ; Dose-Response Relationship, Radiation ; Female ; Humans ; Incidence ; Lung Neoplasms - therapy ; Male ; Middle Aged ; Radiation Pneumonitis - epidemiology ; Radiotherapy Dosage</subject><ispartof>Acta medica Okayama, 2018-10, Vol.72 (5), p.507-513</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30369608$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ogata, Takeshi</creatorcontrib><creatorcontrib>Katsui, Kuniaki</creatorcontrib><creatorcontrib>Yoshio, Kotaro</creatorcontrib><creatorcontrib>Ihara, Hiroki</creatorcontrib><creatorcontrib>Katayama, Norihisa</creatorcontrib><creatorcontrib>Soh, Junichi</creatorcontrib><creatorcontrib>Kuroda, Masahiro</creatorcontrib><creatorcontrib>Kiura, Katsuyuki</creatorcontrib><creatorcontrib>Maeda, Yoshinobu</creatorcontrib><creatorcontrib>Toyooka, Shinichi</creatorcontrib><creatorcontrib>Kanazawa, Susumu</creatorcontrib><title>Dose-Volume Parameters Predict Radiation Pneumonitis after Surgery with Induction Concurrent Chemoradiotherapy for Non-small Cell Lung Cancer</title><title>Acta medica Okayama</title><addtitle>Acta Med Okayama</addtitle><description>To clarify the relationship between dose-volume histogram (DVH) parameters and radiation pneumonitis (RP) after surgery in cases of non-small cell lung cancer (NSCLC) treated with induction concurrent chemoradiotherapy (CCRT). Patients with NSCLC treated with induction CCRT (chemotherapy: cisplatin and docetaxel; radiotherapy: 2.0 Gy fractions once daily for a total of 46 Gy) before surgery were reviewed. We calculated the percentage of lung volume receiving at least 20 Gy (V20) and the mean lung dose (MLD) for the total lung volume and the lung remaining after resection. Factors affecting the incidence of RP at grade 2 or higher (≥ G2 RP) were analyzed. Eighteen of 49 patients (37%) experienced ≥G2 RP. The V20 and MLD for the lung remaining after resection (V20r and MLDr) were significant predictors according to the multivariate analysis (p=0.007 and 0.041, respectively). The incidence of ≥G2 RP was 8% in patients with V20r<10%, and 13% in patients with MLDr<5.6 Gy, respectively. The optimal approach to reduce the rate of postoperative RP in patients with induction CCRT for NSCLC is to keep the V20r below 10% and/or the MLDr below 5.6 Gy in the radiotherapy planning.</description><subject>Aged</subject><subject>Carcinoma, Non-Small-Cell Lung - therapy</subject><subject>Chemoradiotherapy</subject><subject>Dose-Response Relationship, Radiation</subject><subject>Female</subject><subject>Humans</subject><subject>Incidence</subject><subject>Lung Neoplasms - therapy</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Radiation Pneumonitis - epidemiology</subject><subject>Radiotherapy Dosage</subject><issn>0386-300X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kMtOwzAQRb0A0VLY8AHISzahTlw7ybIKr0qFVrzELhrsSZuqsYsfQv0I_pmIx2bu6OroaDSEnKXsMi3KTI6n94uxkNmkPCBDxguZcMbeBuTY-w1jfS3ZERlwxmW_FUPydWU9Jq92GzukS3DQYUDn6dKhblWgj6BbCK01dGkwdta0ofUUmh6iT9Gt0O3pZxvWdGZ0VD9gZY2KzqEJtFpjZ12vsGGNDnZ72lhHH6xJfAfbLa2wH_NoVrQCo9CdkMMGth5P_3JEXm6un6u7ZL64nVXTebLhExESKRkoASIVQrOizLMUSp6C5ipjDULOcsiaXKVal4i60TlTuhCCc5wIaCTnI3Lx6905-xHRh7prveqPAYM2-jpLM1mmXOZ5j57_ofG9Q13vXNuB29f_L-TfXKxzXA</recordid><startdate>20181001</startdate><enddate>20181001</enddate><creator>Ogata, Takeshi</creator><creator>Katsui, Kuniaki</creator><creator>Yoshio, Kotaro</creator><creator>Ihara, Hiroki</creator><creator>Katayama, Norihisa</creator><creator>Soh, Junichi</creator><creator>Kuroda, Masahiro</creator><creator>Kiura, Katsuyuki</creator><creator>Maeda, Yoshinobu</creator><creator>Toyooka, Shinichi</creator><creator>Kanazawa, Susumu</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20181001</creationdate><title>Dose-Volume Parameters Predict Radiation Pneumonitis after Surgery with Induction Concurrent Chemoradiotherapy for Non-small Cell Lung Cancer</title><author>Ogata, Takeshi ; Katsui, Kuniaki ; Yoshio, Kotaro ; Ihara, Hiroki ; Katayama, Norihisa ; Soh, Junichi ; Kuroda, Masahiro ; Kiura, Katsuyuki ; Maeda, Yoshinobu ; Toyooka, Shinichi ; Kanazawa, Susumu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-j345t-660ac5a5155d089721a931ad3c20fea707a2f7c1dd9eedfd70cd85533e45af633</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Aged</topic><topic>Carcinoma, Non-Small-Cell Lung - therapy</topic><topic>Chemoradiotherapy</topic><topic>Dose-Response Relationship, Radiation</topic><topic>Female</topic><topic>Humans</topic><topic>Incidence</topic><topic>Lung Neoplasms - therapy</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Radiation Pneumonitis - epidemiology</topic><topic>Radiotherapy Dosage</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ogata, Takeshi</creatorcontrib><creatorcontrib>Katsui, Kuniaki</creatorcontrib><creatorcontrib>Yoshio, Kotaro</creatorcontrib><creatorcontrib>Ihara, Hiroki</creatorcontrib><creatorcontrib>Katayama, Norihisa</creatorcontrib><creatorcontrib>Soh, Junichi</creatorcontrib><creatorcontrib>Kuroda, Masahiro</creatorcontrib><creatorcontrib>Kiura, Katsuyuki</creatorcontrib><creatorcontrib>Maeda, Yoshinobu</creatorcontrib><creatorcontrib>Toyooka, Shinichi</creatorcontrib><creatorcontrib>Kanazawa, Susumu</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Acta medica Okayama</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ogata, Takeshi</au><au>Katsui, Kuniaki</au><au>Yoshio, Kotaro</au><au>Ihara, Hiroki</au><au>Katayama, Norihisa</au><au>Soh, Junichi</au><au>Kuroda, Masahiro</au><au>Kiura, Katsuyuki</au><au>Maeda, Yoshinobu</au><au>Toyooka, Shinichi</au><au>Kanazawa, Susumu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dose-Volume Parameters Predict Radiation Pneumonitis after Surgery with Induction Concurrent Chemoradiotherapy for Non-small Cell Lung Cancer</atitle><jtitle>Acta medica Okayama</jtitle><addtitle>Acta Med Okayama</addtitle><date>2018-10-01</date><risdate>2018</risdate><volume>72</volume><issue>5</issue><spage>507</spage><epage>513</epage><pages>507-513</pages><issn>0386-300X</issn><abstract>To clarify the relationship between dose-volume histogram (DVH) parameters and radiation pneumonitis (RP) after surgery in cases of non-small cell lung cancer (NSCLC) treated with induction concurrent chemoradiotherapy (CCRT). Patients with NSCLC treated with induction CCRT (chemotherapy: cisplatin and docetaxel; radiotherapy: 2.0 Gy fractions once daily for a total of 46 Gy) before surgery were reviewed. We calculated the percentage of lung volume receiving at least 20 Gy (V20) and the mean lung dose (MLD) for the total lung volume and the lung remaining after resection. Factors affecting the incidence of RP at grade 2 or higher (≥ G2 RP) were analyzed. Eighteen of 49 patients (37%) experienced ≥G2 RP. The V20 and MLD for the lung remaining after resection (V20r and MLDr) were significant predictors according to the multivariate analysis (p=0.007 and 0.041, respectively). The incidence of ≥G2 RP was 8% in patients with V20r<10%, and 13% in patients with MLDr<5.6 Gy, respectively. The optimal approach to reduce the rate of postoperative RP in patients with induction CCRT for NSCLC is to keep the V20r below 10% and/or the MLDr below 5.6 Gy in the radiotherapy planning.</abstract><cop>Japan</cop><pmid>30369608</pmid><doi>10.18926/AMO/56249</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Freely Accessible Japanese Titles; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Aged Carcinoma, Non-Small-Cell Lung - therapy Chemoradiotherapy Dose-Response Relationship, Radiation Female Humans Incidence Lung Neoplasms - therapy Male Middle Aged Radiation Pneumonitis - epidemiology Radiotherapy Dosage |
| title | Dose-Volume Parameters Predict Radiation Pneumonitis after Surgery with Induction Concurrent Chemoradiotherapy for Non-small Cell Lung Cancer |
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