Therapeutic potential of targeting the Wnt/β‐catenin pathway in the treatment of pancreatic cancer
The Wnt/β‐catenin pathway is an important, dysregulated pathway in several tumor types, including pancreatic ductal adenocarcinoma. Although the activation of this pathway is an important component of normal development, its aberrant activation resulting from activating or inactivating mutations in...
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| Veröffentlicht in: | Journal of cellular biochemistry 2019-05, Vol.120 (5), p.6833-6840 |
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| creator | Javadinia, Seyed Alireza Shahidsales, Soodabeh Fanipakdel, Azar Joudi‐Mashhad, Mona Mehramiz, Mehrane Talebian, Sahar Maftouh, Mona Mardani, Ramin Hassanian, Seyed Mahdi Khazaei, Majid Ferns, Gordon A. Avan, Amir |
| description | The Wnt/β‐catenin pathway is an important, dysregulated pathway in several tumor types, including pancreatic ductal adenocarcinoma. Although the activation of this pathway is an important component of normal development, its aberrant activation resulting from activating or inactivating mutations in the
CTNNB1 gene locus, or in the negative regulators AXIN and APC involving stabilization of β‐catenin, and activation of target genes leads to a more aggressive phenotype, suggesting its potential value as a therapeutic target in the treatment of pancreatic ductal adenocarcinoma. A number of small molecule and biologic agents have now been developed for targeting this pathway. This review summarizes the current knowledge about the therapeutic potential of targeting the Wnt pathway with particular emphasis on preclinical/clinical studies in the treatment of pancreatic ductal adenocarcinoma. |
| doi_str_mv | 10.1002/jcb.27835 |
| format | Article |
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CTNNB1 gene locus, or in the negative regulators AXIN and APC involving stabilization of β‐catenin, and activation of target genes leads to a more aggressive phenotype, suggesting its potential value as a therapeutic target in the treatment of pancreatic ductal adenocarcinoma. A number of small molecule and biologic agents have now been developed for targeting this pathway. This review summarizes the current knowledge about the therapeutic potential of targeting the Wnt pathway with particular emphasis on preclinical/clinical studies in the treatment of pancreatic ductal adenocarcinoma.</description><identifier>ISSN: 0730-2312</identifier><identifier>EISSN: 1097-4644</identifier><identifier>DOI: 10.1002/jcb.27835</identifier><identifier>PMID: 30368889</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Adenocarcinoma ; Adenomatous polyposis coli ; Catenin ; CTNNB1 gene ; Mutation ; pancreas ; Pancreatic cancer ; Phenotypes ; Regulators ; Therapeutic applications ; therapeutic target ; Transcription activation ; tumors ; Wnt protein ; Wnt signaling pathway ; Wnt/ β‐catenin</subject><ispartof>Journal of cellular biochemistry, 2019-05, Vol.120 (5), p.6833-6840</ispartof><rights>2018 Wiley Periodicals, Inc.</rights><rights>2019 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3535-1c356d6a120702fc1afa5bc43b7b9d3ee2e6f2b4b07bbfa2ccbc47d096be6e93</citedby><cites>FETCH-LOGICAL-c3535-1c356d6a120702fc1afa5bc43b7b9d3ee2e6f2b4b07bbfa2ccbc47d096be6e93</cites><orcidid>0000-0003-0773-0906 ; 0000-0002-4968-0962</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjcb.27835$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjcb.27835$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30368889$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Javadinia, Seyed Alireza</creatorcontrib><creatorcontrib>Shahidsales, Soodabeh</creatorcontrib><creatorcontrib>Fanipakdel, Azar</creatorcontrib><creatorcontrib>Joudi‐Mashhad, Mona</creatorcontrib><creatorcontrib>Mehramiz, Mehrane</creatorcontrib><creatorcontrib>Talebian, Sahar</creatorcontrib><creatorcontrib>Maftouh, Mona</creatorcontrib><creatorcontrib>Mardani, Ramin</creatorcontrib><creatorcontrib>Hassanian, Seyed Mahdi</creatorcontrib><creatorcontrib>Khazaei, Majid</creatorcontrib><creatorcontrib>Ferns, Gordon A.</creatorcontrib><creatorcontrib>Avan, Amir</creatorcontrib><title>Therapeutic potential of targeting the Wnt/β‐catenin pathway in the treatment of pancreatic cancer</title><title>Journal of cellular biochemistry</title><addtitle>J Cell Biochem</addtitle><description>The Wnt/β‐catenin pathway is an important, dysregulated pathway in several tumor types, including pancreatic ductal adenocarcinoma. Although the activation of this pathway is an important component of normal development, its aberrant activation resulting from activating or inactivating mutations in the
CTNNB1 gene locus, or in the negative regulators AXIN and APC involving stabilization of β‐catenin, and activation of target genes leads to a more aggressive phenotype, suggesting its potential value as a therapeutic target in the treatment of pancreatic ductal adenocarcinoma. A number of small molecule and biologic agents have now been developed for targeting this pathway. This review summarizes the current knowledge about the therapeutic potential of targeting the Wnt pathway with particular emphasis on preclinical/clinical studies in the treatment of pancreatic ductal adenocarcinoma.</description><subject>Adenocarcinoma</subject><subject>Adenomatous polyposis coli</subject><subject>Catenin</subject><subject>CTNNB1 gene</subject><subject>Mutation</subject><subject>pancreas</subject><subject>Pancreatic cancer</subject><subject>Phenotypes</subject><subject>Regulators</subject><subject>Therapeutic applications</subject><subject>therapeutic target</subject><subject>Transcription activation</subject><subject>tumors</subject><subject>Wnt protein</subject><subject>Wnt signaling pathway</subject><subject>Wnt/ β‐catenin</subject><issn>0730-2312</issn><issn>1097-4644</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp1kEtOwzAQhi0EoqWw4AIoEhtYpPUjceIlVDxViU0llpHtTNpUaRIcR1V3HIGzcBAOwUlwSGGBxGpmNN98Gv0InRI8JhjTyUqrMY1iFu6hIcEi8gMeBPtoiCOGfcoIHaCjpllhjIVg9BANGGY8jmMxRDBfgpE1tDbXXl1ZKG0uC6_KPCvNAmxeLjy7BO-5tJOP98_XNy0dk5deLe1yI7eea7u9NSDt2l13p7UsdTc7pXYtmGN0kMmigZNdHaH57c18eu_Pnu4eplczX7OQhT5xhadcEoojTDNNZCZDpQOmIiVSBkCBZ1QFCkdKZZJq7ZZRigVXwEGwEbrotbWpXlpobLLOGw1FIUuo2iahhHJBGAlih57_QVdVa0r3nKMEjoIwiLmjLntKm6ppDGRJbfK1NNuE4KSLPnHRJ9_RO_ZsZ2zVGtJf8idrB0x6YJMXsP3flDxOr3vlFzjWkDg</recordid><startdate>201905</startdate><enddate>201905</enddate><creator>Javadinia, Seyed Alireza</creator><creator>Shahidsales, Soodabeh</creator><creator>Fanipakdel, Azar</creator><creator>Joudi‐Mashhad, Mona</creator><creator>Mehramiz, Mehrane</creator><creator>Talebian, Sahar</creator><creator>Maftouh, Mona</creator><creator>Mardani, Ramin</creator><creator>Hassanian, Seyed Mahdi</creator><creator>Khazaei, Majid</creator><creator>Ferns, Gordon A.</creator><creator>Avan, Amir</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7T7</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-0773-0906</orcidid><orcidid>https://orcid.org/0000-0002-4968-0962</orcidid></search><sort><creationdate>201905</creationdate><title>Therapeutic potential of targeting the Wnt/β‐catenin pathway in the treatment of pancreatic cancer</title><author>Javadinia, Seyed Alireza ; Shahidsales, Soodabeh ; Fanipakdel, Azar ; Joudi‐Mashhad, Mona ; Mehramiz, Mehrane ; Talebian, Sahar ; Maftouh, Mona ; Mardani, Ramin ; Hassanian, Seyed Mahdi ; Khazaei, Majid ; Ferns, Gordon A. ; Avan, Amir</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3535-1c356d6a120702fc1afa5bc43b7b9d3ee2e6f2b4b07bbfa2ccbc47d096be6e93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adenocarcinoma</topic><topic>Adenomatous polyposis coli</topic><topic>Catenin</topic><topic>CTNNB1 gene</topic><topic>Mutation</topic><topic>pancreas</topic><topic>Pancreatic cancer</topic><topic>Phenotypes</topic><topic>Regulators</topic><topic>Therapeutic applications</topic><topic>therapeutic target</topic><topic>Transcription activation</topic><topic>tumors</topic><topic>Wnt protein</topic><topic>Wnt signaling pathway</topic><topic>Wnt/ β‐catenin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Javadinia, Seyed Alireza</creatorcontrib><creatorcontrib>Shahidsales, Soodabeh</creatorcontrib><creatorcontrib>Fanipakdel, Azar</creatorcontrib><creatorcontrib>Joudi‐Mashhad, Mona</creatorcontrib><creatorcontrib>Mehramiz, Mehrane</creatorcontrib><creatorcontrib>Talebian, Sahar</creatorcontrib><creatorcontrib>Maftouh, Mona</creatorcontrib><creatorcontrib>Mardani, Ramin</creatorcontrib><creatorcontrib>Hassanian, Seyed Mahdi</creatorcontrib><creatorcontrib>Khazaei, Majid</creatorcontrib><creatorcontrib>Ferns, Gordon A.</creatorcontrib><creatorcontrib>Avan, Amir</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of cellular biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Javadinia, Seyed Alireza</au><au>Shahidsales, Soodabeh</au><au>Fanipakdel, Azar</au><au>Joudi‐Mashhad, Mona</au><au>Mehramiz, Mehrane</au><au>Talebian, Sahar</au><au>Maftouh, Mona</au><au>Mardani, Ramin</au><au>Hassanian, Seyed Mahdi</au><au>Khazaei, Majid</au><au>Ferns, Gordon A.</au><au>Avan, Amir</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Therapeutic potential of targeting the Wnt/β‐catenin pathway in the treatment of pancreatic cancer</atitle><jtitle>Journal of cellular biochemistry</jtitle><addtitle>J Cell Biochem</addtitle><date>2019-05</date><risdate>2019</risdate><volume>120</volume><issue>5</issue><spage>6833</spage><epage>6840</epage><pages>6833-6840</pages><issn>0730-2312</issn><eissn>1097-4644</eissn><abstract>The Wnt/β‐catenin pathway is an important, dysregulated pathway in several tumor types, including pancreatic ductal adenocarcinoma. 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| subjects | Adenocarcinoma Adenomatous polyposis coli Catenin CTNNB1 gene Mutation pancreas Pancreatic cancer Phenotypes Regulators Therapeutic applications therapeutic target Transcription activation tumors Wnt protein Wnt signaling pathway Wnt/ β‐catenin |
| title | Therapeutic potential of targeting the Wnt/β‐catenin pathway in the treatment of pancreatic cancer |
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