The effects of LXR agonist GW3965 on vascular reactivity and inflammation in hypertensive rat aorta

Liver X receptors (LXRs) play an important role in the regulation of cholesterol, fatty acid and glucose metabolisms together with inflammatory processes. In the present study, the effects of LXR agonist GW3965 on vascular reactivity and expression of functional proteins in DOCA-Salt induced hyperte...

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Veröffentlicht in:	Life sciences (1973) 2018-11, Vol.213, p.287-293
Hauptverfasser:	Han, Sevtap, Bal, Nur Banu, Sadi, Gökhan, Usanmaz, Suzan Emel, Uludag, Mecit Orhan, Demirel-Yilmaz, Emine
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetic acid Acetylcholine Animals Antagonist drugs Aorta Aorta - drug effects Benzoates - metabolism Benzoates - pharmacology Benzylamines - metabolism Benzylamines - pharmacology Blood pressure Blood Pressure - drug effects Ca2+-transporting ATPase Calcium (reticular) Calcium ions Cardiovascular Diseases Cholesterol Contractility Desoxycorticosterone Acetate - pharmacology Disease Models, Animal Endoplasmic reticulum Endothelium Fatty acids GW3965 Hypertension Hypertension - drug therapy Hypertension - physiopathology Inflammation Inflammation - drug therapy Inflammation - physiopathology Liver Liver X receptors Liver X Receptors - agonists Liver X Receptors - metabolism Male Nephrectomy NF-κB protein Nitroprusside - pharmacology Phenylephrine Potassium chloride Pressure effects Proteins Rats Rats, Wistar Receptors Sodium Sodium nitroprusside Transcription factors Tumor necrosis factor-α Vascular tissue
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