Expression of matrix metalloproteinases (MMPs-2, -7, -9, and -26) and tissue inhibitors of metalloproteinases (TIMPs-1 and -2) in pleomorphic adenomas and adenoid cystic carcinomas
Purpose To compare the immunohistochemical expression of matrix metalloproteinases-2, -7, -9 and -26 and tissue inhibitors of metalloproteinases-1 and -2 in pleomorphic adenomas and adenoid cystic carcinomas of the minor salivary glands. Methods Twenty cases of pleomorphic adenomas and 20 cases of a...
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| Veröffentlicht in: | European archives of oto-rhino-laryngology 2018-12, Vol.275 (12), p.3075-3082 |
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| creator | Souza Freitas, Valéria dos Santos, Jean Nunes de Andrade Santos, Pedro Paulo Nonaka, Cassiano Francisco Weege Pereira Pinto, Leão de Souza, Lélia Batista |
| description | Purpose
To compare the immunohistochemical expression of matrix metalloproteinases-2, -7, -9 and -26 and tissue inhibitors of metalloproteinases-1 and -2 in pleomorphic adenomas and adenoid cystic carcinomas of the minor salivary glands.
Methods
Twenty cases of pleomorphic adenomas and 20 cases of adenoid cystic carcinomas were evaluated for the immunohistochemical expression of matrix metalloproteinases-2, -7, -9, and -26 and tissue inhibitors-1 and -2 in tumor parenchyma.
Results
Most pleomorphic adenomas and adenoid cystic carcinomas showed high expression of matrix metalloproteinases and tissue inhibitors, predominantly located in the tumor cells. There was no statistically significant difference in the expression of the metalloproteinases-2 (
p
= 0.359), -7 (
p
= 0.081), and -26 (
p
= 0 553), as well as the tissue inhibitors-1 (
p
= 0.657), and -2 (
p
= 0.248) between the parenchyma of the studied tumors. Only matrix metalloproteinase-9 showed a significant difference in expression between the two tumors, with adenoid cystic carcinoma showing a more intense staining for this gelatinase (
p
= 0.041).
Conclusions
The expression of the studied metalloproteinases suggests the involvement of these enzymes in the tissue remodeling process in pleomorphic adenomas and adenoid cystic carcinomas, but only MMP-9, significantly expressed in the adenoid cystic carcinomas, appears to be involved in the process of invasiveness and more aggressive behavior of these tumors. Additionally, results point that TIMPs-1 and -2 may have more complex functions besides metalloproteinase inhibition, which may be related to the pathogenesis and biological behavior of salivary gland tumors. |
| doi_str_mv | 10.1007/s00405-018-5176-0 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2126907951</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2126907951</sourcerecordid><originalsourceid>FETCH-LOGICAL-c344t-fced90214f4737351c5bb0981bd74630edbfdd8efc64ff696c80005036fcec303</originalsourceid><addsrcrecordid>eNp9kc1u1TAUhC0EoreFB2CDvGylGuzYsZMlqkqp1AoWZW05_qGukjj4JFL7XjwgTu6FVdWFZVsz80nnDEIfGP3EKFWfgVJBa0JZQ2qmJKGv0I4JLohQlXyNdrTligih1BE6BniglNai5W_REadcMtWoHfpz-ThlDxDTiFPAg5lzfMSDn03fpymn2cfRgAd8env7A0h1jokqpz3HZnSYVPJse8wRYPE4jvexi3PKsMGeodxdrxh2SJ-VBJ56n4aUp_tosXF-TIOBTd8-0WH7BHPRrMk2buo79CaYHvz7w32Cfn69vLv4Rm6-X11ffLkhlgsxk2C9a2nFRBCKK14zW3cdbRvWOSUkp951wbnGBytFCLKVtllXVHZTkrbs6ASd7rllhN-Lh1kPEazvezP6tICuWCVbqtqaFSvbW21OANkHPeU4mPykGdVrWXpfli5l6bUsveI_HvBLN3j3P_GvnWKo9gYo0vjLZ_2QljyWkV-g_gVctZ-7</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2126907951</pqid></control><display><type>article</type><title>Expression of matrix metalloproteinases (MMPs-2, -7, -9, and -26) and tissue inhibitors of metalloproteinases (TIMPs-1 and -2) in pleomorphic adenomas and adenoid cystic carcinomas</title><source>MEDLINE</source><source>SpringerNature Journals</source><creator>Souza Freitas, Valéria ; dos Santos, Jean Nunes ; de Andrade Santos, Pedro Paulo ; Nonaka, Cassiano Francisco Weege ; Pereira Pinto, Leão ; de Souza, Lélia Batista</creator><creatorcontrib>Souza Freitas, Valéria ; dos Santos, Jean Nunes ; de Andrade Santos, Pedro Paulo ; Nonaka, Cassiano Francisco Weege ; Pereira Pinto, Leão ; de Souza, Lélia Batista</creatorcontrib><description>Purpose
To compare the immunohistochemical expression of matrix metalloproteinases-2, -7, -9 and -26 and tissue inhibitors of metalloproteinases-1 and -2 in pleomorphic adenomas and adenoid cystic carcinomas of the minor salivary glands.
Methods
Twenty cases of pleomorphic adenomas and 20 cases of adenoid cystic carcinomas were evaluated for the immunohistochemical expression of matrix metalloproteinases-2, -7, -9, and -26 and tissue inhibitors-1 and -2 in tumor parenchyma.
Results
Most pleomorphic adenomas and adenoid cystic carcinomas showed high expression of matrix metalloproteinases and tissue inhibitors, predominantly located in the tumor cells. There was no statistically significant difference in the expression of the metalloproteinases-2 (
p
= 0.359), -7 (
p
= 0.081), and -26 (
p
= 0 553), as well as the tissue inhibitors-1 (
p
= 0.657), and -2 (
p
= 0.248) between the parenchyma of the studied tumors. Only matrix metalloproteinase-9 showed a significant difference in expression between the two tumors, with adenoid cystic carcinoma showing a more intense staining for this gelatinase (
p
= 0.041).
Conclusions
The expression of the studied metalloproteinases suggests the involvement of these enzymes in the tissue remodeling process in pleomorphic adenomas and adenoid cystic carcinomas, but only MMP-9, significantly expressed in the adenoid cystic carcinomas, appears to be involved in the process of invasiveness and more aggressive behavior of these tumors. Additionally, results point that TIMPs-1 and -2 may have more complex functions besides metalloproteinase inhibition, which may be related to the pathogenesis and biological behavior of salivary gland tumors.</description><identifier>ISSN: 0937-4477</identifier><identifier>EISSN: 1434-4726</identifier><identifier>DOI: 10.1007/s00405-018-5176-0</identifier><identifier>PMID: 30361787</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adenoma, Pleomorphic - metabolism ; Adenoma, Pleomorphic - pathology ; Carcinoma, Adenoid Cystic - metabolism ; Carcinoma, Adenoid Cystic - pathology ; Head & Neck ; Head and Neck Surgery ; Humans ; Immunohistochemistry ; Matrix Metalloproteinases - metabolism ; Medicine ; Medicine & Public Health ; Neurosurgery ; Otorhinolaryngology ; Salivary Gland Neoplasms - metabolism ; Salivary Gland Neoplasms - pathology ; Salivary Glands, Minor - metabolism ; Salivary Glands, Minor - pathology ; Tissue Inhibitor of Metalloproteinase-1 - metabolism ; Tissue Inhibitor of Metalloproteinase-2 - metabolism</subject><ispartof>European archives of oto-rhino-laryngology, 2018-12, Vol.275 (12), p.3075-3082</ispartof><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2018</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c344t-fced90214f4737351c5bb0981bd74630edbfdd8efc64ff696c80005036fcec303</citedby><cites>FETCH-LOGICAL-c344t-fced90214f4737351c5bb0981bd74630edbfdd8efc64ff696c80005036fcec303</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00405-018-5176-0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00405-018-5176-0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30361787$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Souza Freitas, Valéria</creatorcontrib><creatorcontrib>dos Santos, Jean Nunes</creatorcontrib><creatorcontrib>de Andrade Santos, Pedro Paulo</creatorcontrib><creatorcontrib>Nonaka, Cassiano Francisco Weege</creatorcontrib><creatorcontrib>Pereira Pinto, Leão</creatorcontrib><creatorcontrib>de Souza, Lélia Batista</creatorcontrib><title>Expression of matrix metalloproteinases (MMPs-2, -7, -9, and -26) and tissue inhibitors of metalloproteinases (TIMPs-1 and -2) in pleomorphic adenomas and adenoid cystic carcinomas</title><title>European archives of oto-rhino-laryngology</title><addtitle>Eur Arch Otorhinolaryngol</addtitle><addtitle>Eur Arch Otorhinolaryngol</addtitle><description>Purpose
To compare the immunohistochemical expression of matrix metalloproteinases-2, -7, -9 and -26 and tissue inhibitors of metalloproteinases-1 and -2 in pleomorphic adenomas and adenoid cystic carcinomas of the minor salivary glands.
Methods
Twenty cases of pleomorphic adenomas and 20 cases of adenoid cystic carcinomas were evaluated for the immunohistochemical expression of matrix metalloproteinases-2, -7, -9, and -26 and tissue inhibitors-1 and -2 in tumor parenchyma.
Results
Most pleomorphic adenomas and adenoid cystic carcinomas showed high expression of matrix metalloproteinases and tissue inhibitors, predominantly located in the tumor cells. There was no statistically significant difference in the expression of the metalloproteinases-2 (
p
= 0.359), -7 (
p
= 0.081), and -26 (
p
= 0 553), as well as the tissue inhibitors-1 (
p
= 0.657), and -2 (
p
= 0.248) between the parenchyma of the studied tumors. Only matrix metalloproteinase-9 showed a significant difference in expression between the two tumors, with adenoid cystic carcinoma showing a more intense staining for this gelatinase (
p
= 0.041).
Conclusions
The expression of the studied metalloproteinases suggests the involvement of these enzymes in the tissue remodeling process in pleomorphic adenomas and adenoid cystic carcinomas, but only MMP-9, significantly expressed in the adenoid cystic carcinomas, appears to be involved in the process of invasiveness and more aggressive behavior of these tumors. Additionally, results point that TIMPs-1 and -2 may have more complex functions besides metalloproteinase inhibition, which may be related to the pathogenesis and biological behavior of salivary gland tumors.</description><subject>Adenoma, Pleomorphic - metabolism</subject><subject>Adenoma, Pleomorphic - pathology</subject><subject>Carcinoma, Adenoid Cystic - metabolism</subject><subject>Carcinoma, Adenoid Cystic - pathology</subject><subject>Head & Neck</subject><subject>Head and Neck Surgery</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Matrix Metalloproteinases - metabolism</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Neurosurgery</subject><subject>Otorhinolaryngology</subject><subject>Salivary Gland Neoplasms - metabolism</subject><subject>Salivary Gland Neoplasms - pathology</subject><subject>Salivary Glands, Minor - metabolism</subject><subject>Salivary Glands, Minor - pathology</subject><subject>Tissue Inhibitor of Metalloproteinase-1 - metabolism</subject><subject>Tissue Inhibitor of Metalloproteinase-2 - metabolism</subject><issn>0937-4477</issn><issn>1434-4726</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc1u1TAUhC0EoreFB2CDvGylGuzYsZMlqkqp1AoWZW05_qGukjj4JFL7XjwgTu6FVdWFZVsz80nnDEIfGP3EKFWfgVJBa0JZQ2qmJKGv0I4JLohQlXyNdrTligih1BE6BniglNai5W_REadcMtWoHfpz-ThlDxDTiFPAg5lzfMSDn03fpymn2cfRgAd8env7A0h1jokqpz3HZnSYVPJse8wRYPE4jvexi3PKsMGeodxdrxh2SJ-VBJ56n4aUp_tosXF-TIOBTd8-0WH7BHPRrMk2buo79CaYHvz7w32Cfn69vLv4Rm6-X11ffLkhlgsxk2C9a2nFRBCKK14zW3cdbRvWOSUkp951wbnGBytFCLKVtllXVHZTkrbs6ASd7rllhN-Lh1kPEazvezP6tICuWCVbqtqaFSvbW21OANkHPeU4mPykGdVrWXpfli5l6bUsveI_HvBLN3j3P_GvnWKo9gYo0vjLZ_2QljyWkV-g_gVctZ-7</recordid><startdate>20181201</startdate><enddate>20181201</enddate><creator>Souza Freitas, Valéria</creator><creator>dos Santos, Jean Nunes</creator><creator>de Andrade Santos, Pedro Paulo</creator><creator>Nonaka, Cassiano Francisco Weege</creator><creator>Pereira Pinto, Leão</creator><creator>de Souza, Lélia Batista</creator><general>Springer Berlin Heidelberg</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20181201</creationdate><title>Expression of matrix metalloproteinases (MMPs-2, -7, -9, and -26) and tissue inhibitors of metalloproteinases (TIMPs-1 and -2) in pleomorphic adenomas and adenoid cystic carcinomas</title><author>Souza Freitas, Valéria ; dos Santos, Jean Nunes ; de Andrade Santos, Pedro Paulo ; Nonaka, Cassiano Francisco Weege ; Pereira Pinto, Leão ; de Souza, Lélia Batista</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c344t-fced90214f4737351c5bb0981bd74630edbfdd8efc64ff696c80005036fcec303</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adenoma, Pleomorphic - metabolism</topic><topic>Adenoma, Pleomorphic - pathology</topic><topic>Carcinoma, Adenoid Cystic - metabolism</topic><topic>Carcinoma, Adenoid Cystic - pathology</topic><topic>Head & Neck</topic><topic>Head and Neck Surgery</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Matrix Metalloproteinases - metabolism</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Neurosurgery</topic><topic>Otorhinolaryngology</topic><topic>Salivary Gland Neoplasms - metabolism</topic><topic>Salivary Gland Neoplasms - pathology</topic><topic>Salivary Glands, Minor - metabolism</topic><topic>Salivary Glands, Minor - pathology</topic><topic>Tissue Inhibitor of Metalloproteinase-1 - metabolism</topic><topic>Tissue Inhibitor of Metalloproteinase-2 - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Souza Freitas, Valéria</creatorcontrib><creatorcontrib>dos Santos, Jean Nunes</creatorcontrib><creatorcontrib>de Andrade Santos, Pedro Paulo</creatorcontrib><creatorcontrib>Nonaka, Cassiano Francisco Weege</creatorcontrib><creatorcontrib>Pereira Pinto, Leão</creatorcontrib><creatorcontrib>de Souza, Lélia Batista</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European archives of oto-rhino-laryngology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Souza Freitas, Valéria</au><au>dos Santos, Jean Nunes</au><au>de Andrade Santos, Pedro Paulo</au><au>Nonaka, Cassiano Francisco Weege</au><au>Pereira Pinto, Leão</au><au>de Souza, Lélia Batista</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Expression of matrix metalloproteinases (MMPs-2, -7, -9, and -26) and tissue inhibitors of metalloproteinases (TIMPs-1 and -2) in pleomorphic adenomas and adenoid cystic carcinomas</atitle><jtitle>European archives of oto-rhino-laryngology</jtitle><stitle>Eur Arch Otorhinolaryngol</stitle><addtitle>Eur Arch Otorhinolaryngol</addtitle><date>2018-12-01</date><risdate>2018</risdate><volume>275</volume><issue>12</issue><spage>3075</spage><epage>3082</epage><pages>3075-3082</pages><issn>0937-4477</issn><eissn>1434-4726</eissn><abstract>Purpose
To compare the immunohistochemical expression of matrix metalloproteinases-2, -7, -9 and -26 and tissue inhibitors of metalloproteinases-1 and -2 in pleomorphic adenomas and adenoid cystic carcinomas of the minor salivary glands.
Methods
Twenty cases of pleomorphic adenomas and 20 cases of adenoid cystic carcinomas were evaluated for the immunohistochemical expression of matrix metalloproteinases-2, -7, -9, and -26 and tissue inhibitors-1 and -2 in tumor parenchyma.
Results
Most pleomorphic adenomas and adenoid cystic carcinomas showed high expression of matrix metalloproteinases and tissue inhibitors, predominantly located in the tumor cells. There was no statistically significant difference in the expression of the metalloproteinases-2 (
p
= 0.359), -7 (
p
= 0.081), and -26 (
p
= 0 553), as well as the tissue inhibitors-1 (
p
= 0.657), and -2 (
p
= 0.248) between the parenchyma of the studied tumors. Only matrix metalloproteinase-9 showed a significant difference in expression between the two tumors, with adenoid cystic carcinoma showing a more intense staining for this gelatinase (
p
= 0.041).
Conclusions
The expression of the studied metalloproteinases suggests the involvement of these enzymes in the tissue remodeling process in pleomorphic adenomas and adenoid cystic carcinomas, but only MMP-9, significantly expressed in the adenoid cystic carcinomas, appears to be involved in the process of invasiveness and more aggressive behavior of these tumors. Additionally, results point that TIMPs-1 and -2 may have more complex functions besides metalloproteinase inhibition, which may be related to the pathogenesis and biological behavior of salivary gland tumors.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>30361787</pmid><doi>10.1007/s00405-018-5176-0</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0937-4477 |
| ispartof | European archives of oto-rhino-laryngology, 2018-12, Vol.275 (12), p.3075-3082 |
| issn | 0937-4477 1434-4726 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2126907951 |
| source | MEDLINE; SpringerNature Journals |
| subjects | Adenoma, Pleomorphic - metabolism Adenoma, Pleomorphic - pathology Carcinoma, Adenoid Cystic - metabolism Carcinoma, Adenoid Cystic - pathology Head & Neck Head and Neck Surgery Humans Immunohistochemistry Matrix Metalloproteinases - metabolism Medicine Medicine & Public Health Neurosurgery Otorhinolaryngology Salivary Gland Neoplasms - metabolism Salivary Gland Neoplasms - pathology Salivary Glands, Minor - metabolism Salivary Glands, Minor - pathology Tissue Inhibitor of Metalloproteinase-1 - metabolism Tissue Inhibitor of Metalloproteinase-2 - metabolism |
| title | Expression of matrix metalloproteinases (MMPs-2, -7, -9, and -26) and tissue inhibitors of metalloproteinases (TIMPs-1 and -2) in pleomorphic adenomas and adenoid cystic carcinomas |
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