Expression of myostatin in human hematopoietic cells unveils novel autocrine/paracrine actions for the hormone
Myostatin is a member of the transforming growth factor β (TGFβ) superfamily that has a well‐established role as a mediator of muscle growth and development. However, myostatin is now emerging as a pleiotropic hormone with multiple actions in the regulation of the metabolism as well as several aspec...
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| Veröffentlicht in: | Journal of cellular physiology 2019-05, Vol.234 (5), p.7236-7246 |
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| creator | Fernández‐Nocelo, Susana Gallego, Rosalía Costoya, José A. Arce, Víctor M. |
| description | Myostatin is a member of the transforming growth factor β (TGFβ) superfamily that has a well‐established role as a mediator of muscle growth and development. However, myostatin is now emerging as a pleiotropic hormone with multiple actions in the regulation of the metabolism as well as several aspects of both cardiac and smooth muscle cells physiology. In addition, myostatin is also expressed in several nonmuscular cells where its physiological role remains to be elucidated in most cases. In this report, we have shown that both myostatin and its receptor system are expressed in blood cells and in hematopoietic cell lines. Furthermore, myostatin treatment promotes differentiation of both HL60 and K562 cells through a mechanism that involves activation of extracellular signal‐regulated kinases 1/2 and p38‐mitogen‐activated protein kinase, thus leading to the possibility that myostatin may be a paracrine/autocrine factor involved in the control of haematopoiesis. In addition, the presence of myostatin expression in immune cells could envisage a novel role for the hormone in the pathogenesis of inflammatory diseases.
Myostatin produced by haematopoietic progenitors could act as an autocrine/paracrine factor regulating haematopoiesis. In addition, myostatin production by peripheral blood cells could be involved in the pathogenesis of both inflammatory myopathies and other inflammatory diseases. |
| doi_str_mv | 10.1002/jcp.27494 |
| format | Article |
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Myostatin produced by haematopoietic progenitors could act as an autocrine/paracrine factor regulating haematopoiesis. In addition, myostatin production by peripheral blood cells could be involved in the pathogenesis of both inflammatory myopathies and other inflammatory diseases.</description><identifier>ISSN: 0021-9541</identifier><identifier>EISSN: 1097-4652</identifier><identifier>DOI: 10.1002/jcp.27494</identifier><identifier>PMID: 30370618</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Adult ; Autocrine Communication ; Autocrine signalling ; Blood cells ; Blood Cells - metabolism ; Cell lines ; Cell Survival ; Extracellular Signal-Regulated MAP Kinases - metabolism ; Female ; Growth factors ; haematopoiesis ; Hematopoiesis ; HL-60 Cells ; Humans ; Immune system ; inflammation ; Inflammatory diseases ; Jurkat Cells ; K562 Cells ; Kinases ; Male ; Metabolism ; Muscles ; Myositis - blood ; Myositis - metabolism ; Myostatin ; Myostatin - genetics ; Myostatin - metabolism ; p38 Mitogen-Activated Protein Kinases - metabolism ; paracrine ; Paracrine Communication ; Paracrine signalling ; Pathogenesis ; Physiology ; Protein kinase ; Proteins ; Signal Transduction ; Smooth muscle ; Transforming growth factor-b</subject><ispartof>Journal of cellular physiology, 2019-05, Vol.234 (5), p.7236-7246</ispartof><rights>2018 Wiley Periodicals, Inc.</rights><rights>2019 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3534-1ac90d9a4d30921218c71e92f19c25757f7c469a5d3d1bbbcba5c5b49f26c5973</citedby><cites>FETCH-LOGICAL-c3534-1ac90d9a4d30921218c71e92f19c25757f7c469a5d3d1bbbcba5c5b49f26c5973</cites><orcidid>0000-0003-3691-6419 ; 0000-0003-2391-6217</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjcp.27494$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjcp.27494$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30370618$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fernández‐Nocelo, Susana</creatorcontrib><creatorcontrib>Gallego, Rosalía</creatorcontrib><creatorcontrib>Costoya, José A.</creatorcontrib><creatorcontrib>Arce, Víctor M.</creatorcontrib><title>Expression of myostatin in human hematopoietic cells unveils novel autocrine/paracrine actions for the hormone</title><title>Journal of cellular physiology</title><addtitle>J Cell Physiol</addtitle><description>Myostatin is a member of the transforming growth factor β (TGFβ) superfamily that has a well‐established role as a mediator of muscle growth and development. However, myostatin is now emerging as a pleiotropic hormone with multiple actions in the regulation of the metabolism as well as several aspects of both cardiac and smooth muscle cells physiology. In addition, myostatin is also expressed in several nonmuscular cells where its physiological role remains to be elucidated in most cases. In this report, we have shown that both myostatin and its receptor system are expressed in blood cells and in hematopoietic cell lines. Furthermore, myostatin treatment promotes differentiation of both HL60 and K562 cells through a mechanism that involves activation of extracellular signal‐regulated kinases 1/2 and p38‐mitogen‐activated protein kinase, thus leading to the possibility that myostatin may be a paracrine/autocrine factor involved in the control of haematopoiesis. In addition, the presence of myostatin expression in immune cells could envisage a novel role for the hormone in the pathogenesis of inflammatory diseases.
Myostatin produced by haematopoietic progenitors could act as an autocrine/paracrine factor regulating haematopoiesis. In addition, myostatin production by peripheral blood cells could be involved in the pathogenesis of both inflammatory myopathies and other inflammatory diseases.</description><subject>Adult</subject><subject>Autocrine Communication</subject><subject>Autocrine signalling</subject><subject>Blood cells</subject><subject>Blood Cells - metabolism</subject><subject>Cell lines</subject><subject>Cell Survival</subject><subject>Extracellular Signal-Regulated MAP Kinases - metabolism</subject><subject>Female</subject><subject>Growth factors</subject><subject>haematopoiesis</subject><subject>Hematopoiesis</subject><subject>HL-60 Cells</subject><subject>Humans</subject><subject>Immune system</subject><subject>inflammation</subject><subject>Inflammatory diseases</subject><subject>Jurkat Cells</subject><subject>K562 Cells</subject><subject>Kinases</subject><subject>Male</subject><subject>Metabolism</subject><subject>Muscles</subject><subject>Myositis - blood</subject><subject>Myositis - metabolism</subject><subject>Myostatin</subject><subject>Myostatin - genetics</subject><subject>Myostatin - metabolism</subject><subject>p38 Mitogen-Activated Protein Kinases - metabolism</subject><subject>paracrine</subject><subject>Paracrine Communication</subject><subject>Paracrine signalling</subject><subject>Pathogenesis</subject><subject>Physiology</subject><subject>Protein kinase</subject><subject>Proteins</subject><subject>Signal Transduction</subject><subject>Smooth muscle</subject><subject>Transforming growth factor-b</subject><issn>0021-9541</issn><issn>1097-4652</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kctKAzEUhoMotlYXvoAE3Ohi2lwmk2Yppd4o6ELXQyaToSkzyZjMVPv2phddCELIOXA-Pg7nB-ASozFGiExWqh0Tnor0CAwxEjxJM0aOwTDOcCJYigfgLIQVQkgISk_BgCLKUYanQ2DnX63XIRhnoatgs3Ghk52xML5l38j460Z2rnVGd0ZBpes6wN6utYnVurWuoew7p7yxetJKL3cdlKqLygAr52G31HDpfOOsPgcnlayDvjjUEXi_n7_NHpPFy8PT7G6RKMpommCpBCqFTEuKBMEETxXHWpAKC0UYZ7ziKs2EZCUtcVEUqpBMsSIVFckUE5yOwM3e23r30evQ5Y0J292l1a4PeXRmAjGCaESv_6Ar13sbt4tUJkjGyZRF6nZPKe9C8LrKW28a6Tc5Rvk2hDyGkO9CiOzVwdgXjS5_yZ-rR2CyBz5NrTf_m_Ln2ete-Q1_gZH3</recordid><startdate>201905</startdate><enddate>201905</enddate><creator>Fernández‐Nocelo, Susana</creator><creator>Gallego, Rosalía</creator><creator>Costoya, José A.</creator><creator>Arce, Víctor M.</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-3691-6419</orcidid><orcidid>https://orcid.org/0000-0003-2391-6217</orcidid></search><sort><creationdate>201905</creationdate><title>Expression of myostatin in human hematopoietic cells unveils novel autocrine/paracrine actions for the hormone</title><author>Fernández‐Nocelo, Susana ; Gallego, Rosalía ; Costoya, José A. ; Arce, Víctor M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3534-1ac90d9a4d30921218c71e92f19c25757f7c469a5d3d1bbbcba5c5b49f26c5973</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adult</topic><topic>Autocrine Communication</topic><topic>Autocrine signalling</topic><topic>Blood cells</topic><topic>Blood Cells - metabolism</topic><topic>Cell lines</topic><topic>Cell Survival</topic><topic>Extracellular Signal-Regulated MAP Kinases - metabolism</topic><topic>Female</topic><topic>Growth factors</topic><topic>haematopoiesis</topic><topic>Hematopoiesis</topic><topic>HL-60 Cells</topic><topic>Humans</topic><topic>Immune system</topic><topic>inflammation</topic><topic>Inflammatory diseases</topic><topic>Jurkat Cells</topic><topic>K562 Cells</topic><topic>Kinases</topic><topic>Male</topic><topic>Metabolism</topic><topic>Muscles</topic><topic>Myositis - blood</topic><topic>Myositis - metabolism</topic><topic>Myostatin</topic><topic>Myostatin - genetics</topic><topic>Myostatin - metabolism</topic><topic>p38 Mitogen-Activated Protein Kinases - metabolism</topic><topic>paracrine</topic><topic>Paracrine Communication</topic><topic>Paracrine signalling</topic><topic>Pathogenesis</topic><topic>Physiology</topic><topic>Protein kinase</topic><topic>Proteins</topic><topic>Signal Transduction</topic><topic>Smooth muscle</topic><topic>Transforming growth factor-b</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fernández‐Nocelo, Susana</creatorcontrib><creatorcontrib>Gallego, Rosalía</creatorcontrib><creatorcontrib>Costoya, José A.</creatorcontrib><creatorcontrib>Arce, Víctor M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of cellular physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fernández‐Nocelo, Susana</au><au>Gallego, Rosalía</au><au>Costoya, José A.</au><au>Arce, Víctor M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Expression of myostatin in human hematopoietic cells unveils novel autocrine/paracrine actions for the hormone</atitle><jtitle>Journal of cellular physiology</jtitle><addtitle>J Cell Physiol</addtitle><date>2019-05</date><risdate>2019</risdate><volume>234</volume><issue>5</issue><spage>7236</spage><epage>7246</epage><pages>7236-7246</pages><issn>0021-9541</issn><eissn>1097-4652</eissn><abstract>Myostatin is a member of the transforming growth factor β (TGFβ) superfamily that has a well‐established role as a mediator of muscle growth and development. 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Myostatin produced by haematopoietic progenitors could act as an autocrine/paracrine factor regulating haematopoiesis. In addition, myostatin production by peripheral blood cells could be involved in the pathogenesis of both inflammatory myopathies and other inflammatory diseases.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>30370618</pmid><doi>10.1002/jcp.27494</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0003-3691-6419</orcidid><orcidid>https://orcid.org/0000-0003-2391-6217</orcidid></addata></record> |
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| ispartof | Journal of cellular physiology, 2019-05, Vol.234 (5), p.7236-7246 |
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| subjects | Adult Autocrine Communication Autocrine signalling Blood cells Blood Cells - metabolism Cell lines Cell Survival Extracellular Signal-Regulated MAP Kinases - metabolism Female Growth factors haematopoiesis Hematopoiesis HL-60 Cells Humans Immune system inflammation Inflammatory diseases Jurkat Cells K562 Cells Kinases Male Metabolism Muscles Myositis - blood Myositis - metabolism Myostatin Myostatin - genetics Myostatin - metabolism p38 Mitogen-Activated Protein Kinases - metabolism paracrine Paracrine Communication Paracrine signalling Pathogenesis Physiology Protein kinase Proteins Signal Transduction Smooth muscle Transforming growth factor-b |
| title | Expression of myostatin in human hematopoietic cells unveils novel autocrine/paracrine actions for the hormone |
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