A Distinct Metabolite Profile Correlates with Neurodegenerative Conditions and the Severity of Congenital Hydrocephalus
Abstract In congenital hydrocephalus, cerebrospinal fluid accumulation is associated with increased intracranial pressure (ICP), ischemia/hypoxia, metabolic impairment, neuronal damage, and astrocytic reaction. The aim of this study was to identify whether a metabolite profile revealing tissue respo...
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| Veröffentlicht in: | Journal of neuropathology and experimental neurology 2018-12, Vol.77 (12), p.1122-1136 |
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| creator | García-Bonilla, María García-Martín, María L Muñoz-Hernández, M Carmen Domínguez-Pinos, Dolores Martínez-León, María I Peñalver, Ana Castilla, Laura Alonso, Francisco J Márquez, Javier Shumilov, Kirill Hidalgo-Sánchez, Ramón Gutiérrez, Antonia Páez-González, Patricia Jiménez, Antonio J |
| description | Abstract
In congenital hydrocephalus, cerebrospinal fluid accumulation is associated with increased intracranial pressure (ICP), ischemia/hypoxia, metabolic impairment, neuronal damage, and astrocytic reaction. The aim of this study was to identify whether a metabolite profile revealing tissue responses according to the severity of hydrocephalus can be detected. The hyh mutant mouse used for this study exhibits 2 different forms of hydrocephalus, severe and moderate. In a comprehensive investigation into the 2 progressions of hydrocephalus, mice with severe hydrocephalus were found to have higher ICP and astrocytic reaction. Several metabolites from the mouse brain cortex were analyzed with 1H high-resolution magic angle spinning nuclear magnetic resonance (1H HR-MAS NMR) spectroscopy. A differential profile for metabolites including glutamate and glutamine was found to correlate with the severity of hydrocephalus and can be explained due to differential astrocytic reactions, neurodegenerative conditions, and the presence of ischemia. The glutamate transporter EAAT2 and the metabolite taurine were found to be key histopathological markers of affected parenchymata. In conclusion, a differential metabolite profile can be detected according to the severity of hydrocephalus and associated ICP and therefore can be used to monitor the efficacy of experimental therapies. |
| doi_str_mv | 10.1093/jnen/nly097 |
| format | Article |
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In congenital hydrocephalus, cerebrospinal fluid accumulation is associated with increased intracranial pressure (ICP), ischemia/hypoxia, metabolic impairment, neuronal damage, and astrocytic reaction. The aim of this study was to identify whether a metabolite profile revealing tissue responses according to the severity of hydrocephalus can be detected. The hyh mutant mouse used for this study exhibits 2 different forms of hydrocephalus, severe and moderate. In a comprehensive investigation into the 2 progressions of hydrocephalus, mice with severe hydrocephalus were found to have higher ICP and astrocytic reaction. Several metabolites from the mouse brain cortex were analyzed with 1H high-resolution magic angle spinning nuclear magnetic resonance (1H HR-MAS NMR) spectroscopy. A differential profile for metabolites including glutamate and glutamine was found to correlate with the severity of hydrocephalus and can be explained due to differential astrocytic reactions, neurodegenerative conditions, and the presence of ischemia. The glutamate transporter EAAT2 and the metabolite taurine were found to be key histopathological markers of affected parenchymata. In conclusion, a differential metabolite profile can be detected according to the severity of hydrocephalus and associated ICP and therefore can be used to monitor the efficacy of experimental therapies.</description><identifier>ISSN: 0022-3069</identifier><identifier>EISSN: 1554-6578</identifier><identifier>DOI: 10.1093/jnen/nly097</identifier><identifier>PMID: 30364991</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>Analysis ; Diagnostic imaging ; Genetic disorders ; Glutamate ; Glutamine ; Hydrocephalus ; Intracranial hypertension ; Intracranial pressure ; Ischemia ; Metabolites ; Neurons ; NMR ; Nuclear magnetic resonance ; Nuclear magnetic resonance spectroscopy ; Spectroscopy ; Taurine</subject><ispartof>Journal of neuropathology and experimental neurology, 2018-12, Vol.77 (12), p.1122-1136</ispartof><rights>2018 American Association of Neuropathologists, Inc. All rights reserved. 2018</rights><rights>2018 by American Association of Neuropathologists, Inc.</rights><rights>COPYRIGHT 2018 Oxford University Press</rights><rights>2018 American Association of Neuropathologists, Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c4507-791ab893adc760edeb9b8860ef98dbf4fd0c9bde13ec80255c7c5c6b1c5406bc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1578,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30364991$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>García-Bonilla, María</creatorcontrib><creatorcontrib>García-Martín, María L</creatorcontrib><creatorcontrib>Muñoz-Hernández, M Carmen</creatorcontrib><creatorcontrib>Domínguez-Pinos, Dolores</creatorcontrib><creatorcontrib>Martínez-León, María I</creatorcontrib><creatorcontrib>Peñalver, Ana</creatorcontrib><creatorcontrib>Castilla, Laura</creatorcontrib><creatorcontrib>Alonso, Francisco J</creatorcontrib><creatorcontrib>Márquez, Javier</creatorcontrib><creatorcontrib>Shumilov, Kirill</creatorcontrib><creatorcontrib>Hidalgo-Sánchez, Ramón</creatorcontrib><creatorcontrib>Gutiérrez, Antonia</creatorcontrib><creatorcontrib>Páez-González, Patricia</creatorcontrib><creatorcontrib>Jiménez, Antonio J</creatorcontrib><title>A Distinct Metabolite Profile Correlates with Neurodegenerative Conditions and the Severity of Congenital Hydrocephalus</title><title>Journal of neuropathology and experimental neurology</title><addtitle>J Neuropathol Exp Neurol</addtitle><description>Abstract
In congenital hydrocephalus, cerebrospinal fluid accumulation is associated with increased intracranial pressure (ICP), ischemia/hypoxia, metabolic impairment, neuronal damage, and astrocytic reaction. The aim of this study was to identify whether a metabolite profile revealing tissue responses according to the severity of hydrocephalus can be detected. The hyh mutant mouse used for this study exhibits 2 different forms of hydrocephalus, severe and moderate. In a comprehensive investigation into the 2 progressions of hydrocephalus, mice with severe hydrocephalus were found to have higher ICP and astrocytic reaction. Several metabolites from the mouse brain cortex were analyzed with 1H high-resolution magic angle spinning nuclear magnetic resonance (1H HR-MAS NMR) spectroscopy. A differential profile for metabolites including glutamate and glutamine was found to correlate with the severity of hydrocephalus and can be explained due to differential astrocytic reactions, neurodegenerative conditions, and the presence of ischemia. The glutamate transporter EAAT2 and the metabolite taurine were found to be key histopathological markers of affected parenchymata. In conclusion, a differential metabolite profile can be detected according to the severity of hydrocephalus and associated ICP and therefore can be used to monitor the efficacy of experimental therapies.</description><subject>Analysis</subject><subject>Diagnostic imaging</subject><subject>Genetic disorders</subject><subject>Glutamate</subject><subject>Glutamine</subject><subject>Hydrocephalus</subject><subject>Intracranial hypertension</subject><subject>Intracranial pressure</subject><subject>Ischemia</subject><subject>Metabolites</subject><subject>Neurons</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Nuclear magnetic resonance spectroscopy</subject><subject>Spectroscopy</subject><subject>Taurine</subject><issn>0022-3069</issn><issn>1554-6578</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNp9kd2L1DAUxYso7rj65LsEBBGkO7cfSZvHYfxYYf0A9Tmkye02YyYZk3SH-e9t6aooKnlIIL9z7uGeLHtcwEUBvFrvHLq1syfgzZ1sVVBa54w27d1sBVCWeQWMn2UPYtwBAAde38_OKqhYzXmxyo4b8tLEZJxK5B0m2XlrEpKPwffGItn6ENDKhJEcTRrIexyD13iNDoNM5mYmnDbJeBeJdJqkAcknvMFg0on4fv6eYJOkJZcnHbzCwyDtGB9m93ppIz66vc-zL69ffd5e5lcf3rzdbq5yVVNo8oYXsmt5JbVqGKDGjndtO7163uqur3sNincaiwpVCyWlqlFUsa5QtAbWqeo8e774HoL_NmJMYm-iQmulQz9GURYl41ADsAl9-ge682NwUzpRTgtrGaWs_kVdS4vCuN6nINVsKjZ0SlYyYDBRF3-hpqNxb5R3OG_3d8GLRaCCjzFgLw7B7GU4iQLEXLOYaxZLzRP95Dbq2O1R_2R_9DoB6wU4epswxK92PGIQA0qbhn9YPlsUfjz8d_Z3xJ3C0A</recordid><startdate>201812</startdate><enddate>201812</enddate><creator>García-Bonilla, María</creator><creator>García-Martín, María L</creator><creator>Muñoz-Hernández, M Carmen</creator><creator>Domínguez-Pinos, Dolores</creator><creator>Martínez-León, María I</creator><creator>Peñalver, Ana</creator><creator>Castilla, Laura</creator><creator>Alonso, Francisco J</creator><creator>Márquez, Javier</creator><creator>Shumilov, Kirill</creator><creator>Hidalgo-Sánchez, Ramón</creator><creator>Gutiérrez, Antonia</creator><creator>Páez-González, Patricia</creator><creator>Jiménez, Antonio J</creator><general>Oxford University Press</general><general>by American Association of Neuropathologists, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>88I</scope><scope>8AF</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>S0X</scope><scope>7X8</scope></search><sort><creationdate>201812</creationdate><title>A Distinct Metabolite Profile Correlates with Neurodegenerative Conditions and the Severity of Congenital Hydrocephalus</title><author>García-Bonilla, María ; García-Martín, María L ; Muñoz-Hernández, M Carmen ; Domínguez-Pinos, Dolores ; Martínez-León, María I ; Peñalver, Ana ; Castilla, Laura ; Alonso, Francisco J ; Márquez, Javier ; Shumilov, Kirill ; Hidalgo-Sánchez, Ramón ; Gutiérrez, Antonia ; Páez-González, Patricia ; Jiménez, Antonio J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4507-791ab893adc760edeb9b8860ef98dbf4fd0c9bde13ec80255c7c5c6b1c5406bc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Analysis</topic><topic>Diagnostic imaging</topic><topic>Genetic disorders</topic><topic>Glutamate</topic><topic>Glutamine</topic><topic>Hydrocephalus</topic><topic>Intracranial hypertension</topic><topic>Intracranial pressure</topic><topic>Ischemia</topic><topic>Metabolites</topic><topic>Neurons</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Nuclear magnetic resonance spectroscopy</topic><topic>Spectroscopy</topic><topic>Taurine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>García-Bonilla, María</creatorcontrib><creatorcontrib>García-Martín, María L</creatorcontrib><creatorcontrib>Muñoz-Hernández, M Carmen</creatorcontrib><creatorcontrib>Domínguez-Pinos, Dolores</creatorcontrib><creatorcontrib>Martínez-León, María I</creatorcontrib><creatorcontrib>Peñalver, Ana</creatorcontrib><creatorcontrib>Castilla, Laura</creatorcontrib><creatorcontrib>Alonso, Francisco J</creatorcontrib><creatorcontrib>Márquez, Javier</creatorcontrib><creatorcontrib>Shumilov, Kirill</creatorcontrib><creatorcontrib>Hidalgo-Sánchez, Ramón</creatorcontrib><creatorcontrib>Gutiérrez, Antonia</creatorcontrib><creatorcontrib>Páez-González, Patricia</creatorcontrib><creatorcontrib>Jiménez, Antonio J</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>SIRS Editorial</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of neuropathology and experimental neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>García-Bonilla, María</au><au>García-Martín, María L</au><au>Muñoz-Hernández, M Carmen</au><au>Domínguez-Pinos, Dolores</au><au>Martínez-León, María I</au><au>Peñalver, Ana</au><au>Castilla, Laura</au><au>Alonso, Francisco J</au><au>Márquez, Javier</au><au>Shumilov, Kirill</au><au>Hidalgo-Sánchez, Ramón</au><au>Gutiérrez, Antonia</au><au>Páez-González, Patricia</au><au>Jiménez, Antonio J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Distinct Metabolite Profile Correlates with Neurodegenerative Conditions and the Severity of Congenital Hydrocephalus</atitle><jtitle>Journal of neuropathology and experimental neurology</jtitle><addtitle>J Neuropathol Exp Neurol</addtitle><date>2018-12</date><risdate>2018</risdate><volume>77</volume><issue>12</issue><spage>1122</spage><epage>1136</epage><pages>1122-1136</pages><issn>0022-3069</issn><eissn>1554-6578</eissn><abstract>Abstract
In congenital hydrocephalus, cerebrospinal fluid accumulation is associated with increased intracranial pressure (ICP), ischemia/hypoxia, metabolic impairment, neuronal damage, and astrocytic reaction. The aim of this study was to identify whether a metabolite profile revealing tissue responses according to the severity of hydrocephalus can be detected. The hyh mutant mouse used for this study exhibits 2 different forms of hydrocephalus, severe and moderate. In a comprehensive investigation into the 2 progressions of hydrocephalus, mice with severe hydrocephalus were found to have higher ICP and astrocytic reaction. Several metabolites from the mouse brain cortex were analyzed with 1H high-resolution magic angle spinning nuclear magnetic resonance (1H HR-MAS NMR) spectroscopy. A differential profile for metabolites including glutamate and glutamine was found to correlate with the severity of hydrocephalus and can be explained due to differential astrocytic reactions, neurodegenerative conditions, and the presence of ischemia. The glutamate transporter EAAT2 and the metabolite taurine were found to be key histopathological markers of affected parenchymata. In conclusion, a differential metabolite profile can be detected according to the severity of hydrocephalus and associated ICP and therefore can be used to monitor the efficacy of experimental therapies.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>30364991</pmid><doi>10.1093/jnen/nly097</doi><tpages>15</tpages><oa>free_for_read</oa></addata></record> |
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| source | Oxford University Press Journals All Titles (1996-Current); Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Analysis Diagnostic imaging Genetic disorders Glutamate Glutamine Hydrocephalus Intracranial hypertension Intracranial pressure Ischemia Metabolites Neurons NMR Nuclear magnetic resonance Nuclear magnetic resonance spectroscopy Spectroscopy Taurine |
| title | A Distinct Metabolite Profile Correlates with Neurodegenerative Conditions and the Severity of Congenital Hydrocephalus |
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