Conjugation to Ascorbic Acid Enhances Brain Availability of Losartan Carboxylic Acid and Protects Against Parkinsonism in Rats

Identification of renin-angiotensin system in the interplay of hypertension and neurodegeneration has paved the way for the repurposing of antihypertensive drugs against Parkinsonism. Losartan carboxylic acid (LCA), the potent AT1 blocker metabolite of losartan, suffers from poor bioavailability and...

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Veröffentlicht in:	The AAPS journal 2018-10, Vol.20 (6), p.110-110, Article 110
Hauptverfasser:	Subudhi, Bharat Bhusan, Sahu, Pratap Kumar, Singh, Vijay Kumar, Prusty, Shaktiketan
Format:	Artikel
Sprache:	eng
Schlagworte:	Biochemistry Biomedical and Life Sciences Biomedicine Biotechnology Pharmacology/Toxicology Pharmacy Research Article
Online-Zugang:	Volltext
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