β‐Ketoiminato Iridium(III) Organometallic Complexes: Selective Cytotoxicity towards Colorectal Cancer Cells HCT116 p53

This report presents a new library of organometallic iridium(III) compounds of the type [Cp*IrCl(L)] (Cp*=pentamethylcyclopentadienyl and L=a functionalized β‐ketoiminato ligand) showing moderate to high cytotoxicity against a range of cancer cell lines. All compounds show increased activity towards...

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Veröffentlicht in:	Chemistry : a European journal 2019-01, Vol.25 (2), p.495-500
Hauptverfasser:	Lord, Rianne M., Zegke, Markus, Henderson, Imogen R., Pask, Christopher M., Shepherd, Helena J., McGowan, Patrick C.
Format:	Artikel
Sprache:	eng
Schlagworte:	bioinorganic chemistry Cancer Cisplatin Colorectal cancer Colorectal carcinoma Cytotoxicity Iridium Iridium compounds organometallic Organometallic complexes Organometallic compounds p53 Protein Selectivity Tumor cell lines
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