Antiviral resistance mutations potentiate hepatitis B virus immune evasion through disruption of its surface antigen a determinant

The hepatitis B virus (HBV) pol gene overlaps the S gene encoding surface antigen (HBsAg). It has been reported previously that drug-induced changes in HBsAg alter its binding to sera from humans immunized against HBV. We investigate here the changes to specific epitopes in the a determinant (the ma...

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Veröffentlicht in:	Antiviral therapy 2008-01, Vol.13 (3), p.439-448
Hauptverfasser:	Sloan, Richard D, Ijaz, Samreen, Moore, Penny L, Harrison, Tim J, Teo, Chong-Gee, Tedder, Richard S
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenine - analogs & derivatives Adenine - pharmacology Animals Antibodies, Monoclonal - immunology Antigen-Antibody Reactions Antiviral Agents - pharmacology CHO Cells Cricetinae Cricetulus Drug Resistance, Multiple, Viral - genetics Enzyme-Linked Immunosorbent Assay Epitope Mapping Gene Expression Regulation, Enzymologic Gene Expression Regulation, Viral - drug effects Gene Products, pol - genetics Guanine - analogs & derivatives Guanine - pharmacology Hepatitis B Antibodies - immunology Hepatitis B Surface Antigens - genetics Hepatitis B Surface Antigens - immunology Hepatitis B virus Hepatitis B virus - drug effects Hepatitis B virus - enzymology Hepatitis B virus - genetics Hepatitis B virus - immunology Humans Immunodominant Epitopes - genetics Lamivudine - pharmacology Mutagenesis, Site-Directed Mutation Organophosphonates - pharmacology Transfection
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