Major histopathological patterns of lung cancer related to arsenic exposure in German uranium miners
Objective The mechanisms of action of arsenic in the development of lung cancer are still not yet elucidated. Considering the relationship between arsenic and squamous cell carcinomas of the skin, we hypothesized that arsenic exposure may be more closely associated with squamous cell carcinoma of th...
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| Veröffentlicht in: | International archives of occupational and environmental health 2009-07, Vol.82 (7), p.867-875 |
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| creator | Taeger, Dirk Johnen, Georg Wiethege, Thorsten Tapio, Soile Möhner, Matthias Wesch, Horst Tannapfel, Andrea Müller, Klaus-Michael Brüning, Thomas Pesch, Beate |
| description | Objective
The mechanisms of action of arsenic in the development of lung cancer are still not yet elucidated. Considering the relationship between arsenic and squamous cell carcinomas of the skin, we hypothesized that arsenic exposure may be more closely associated with squamous cell carcinoma of the lung.
Methods
A comprehensive histopathological database and a detailed job-exposure matrix developed for former German uranium miners with exposure to arsenic, radon, and quartz were analyzed to quantitatively assess the effect of arsenic regarding cell type of lung cancer. The distributions of major lung cancer cell types in 1,786 German uranium miners were associated with levels of arsenic exposure under control for the other lung carcinogens. To evaluate the arsenic effects in association with a frequent occupational lung disease in miners stratification by silicosis was performed.
Results
There was an arsenic-related increase of the proportion of squamous cell carcinoma of the lung but restricted to miners without silicosis. The increase was found at all levels of co-exposure to radon and quartz dust. In miners with silicosis, the proportion of adenocarcinoma increased with rising arsenic exposure. Arsenic exposure was associated with non-small cell lung cancer. Silicosis turned out as major determinant of the cell type related with arsenic.
Conclusion
These results indicate a cell type characteristic effect of arsenic in the development of lung cancer. |
| doi_str_mv | 10.1007/s00420-008-0386-1 |
| format | Article |
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The mechanisms of action of arsenic in the development of lung cancer are still not yet elucidated. Considering the relationship between arsenic and squamous cell carcinomas of the skin, we hypothesized that arsenic exposure may be more closely associated with squamous cell carcinoma of the lung.
Methods
A comprehensive histopathological database and a detailed job-exposure matrix developed for former German uranium miners with exposure to arsenic, radon, and quartz were analyzed to quantitatively assess the effect of arsenic regarding cell type of lung cancer. The distributions of major lung cancer cell types in 1,786 German uranium miners were associated with levels of arsenic exposure under control for the other lung carcinogens. To evaluate the arsenic effects in association with a frequent occupational lung disease in miners stratification by silicosis was performed.
Results
There was an arsenic-related increase of the proportion of squamous cell carcinoma of the lung but restricted to miners without silicosis. The increase was found at all levels of co-exposure to radon and quartz dust. In miners with silicosis, the proportion of adenocarcinoma increased with rising arsenic exposure. Arsenic exposure was associated with non-small cell lung cancer. Silicosis turned out as major determinant of the cell type related with arsenic.
Conclusion
These results indicate a cell type characteristic effect of arsenic in the development of lung cancer.</description><identifier>ISSN: 0340-0131</identifier><identifier>EISSN: 1432-1246</identifier><identifier>DOI: 10.1007/s00420-008-0386-1</identifier><identifier>PMID: 19020892</identifier><identifier>CODEN: IAEHDW</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Adenocarcinoma - chemically induced ; Adenocarcinoma - epidemiology ; Adenocarcinoma - pathology ; Aged ; Air Pollutants - adverse effects ; Arsenic ; Arsenicals - adverse effects ; Biological and medical sciences ; Carcinoma, Non-Small-Cell Lung - chemically induced ; Carcinoma, Non-Small-Cell Lung - epidemiology ; Carcinoma, Non-Small-Cell Lung - pathology ; Carcinoma, Squamous Cell - chemically induced ; Carcinoma, Squamous Cell - epidemiology ; Carcinoma, Squamous Cell - pathology ; Chemical and industrial products toxicology. Toxic occupational diseases ; Dust ; Earth and Environmental Science ; Environment ; Environmental Health ; Germany - epidemiology ; Humans ; Inorganic dusts (pneumoconiosises) and organic dusts (byssinosis etc.) ; Lung cancer ; Lung Neoplasms - chemically induced ; Lung Neoplasms - epidemiology ; Lung Neoplasms - pathology ; Male ; Medical sciences ; Metals and various inorganic compounds ; Middle Aged ; Mining ; Mining industry ; Occupational diseases ; Occupational Diseases - chemically induced ; Occupational Diseases - epidemiology ; Occupational Diseases - pathology ; Occupational exposure ; Occupational hazards ; Occupational Medicine/Industrial Medicine ; Original Article ; Pneumology ; Quartz ; Quartz - adverse effects ; Radon ; Radon - adverse effects ; Rehabilitation ; Silicosis ; Silicosis - epidemiology ; Silicosis - etiology ; Silicosis - pathology ; Toxicology ; Tumors of the respiratory system and mediastinum ; Uranium</subject><ispartof>International archives of occupational and environmental health, 2009-07, Vol.82 (7), p.867-875</ispartof><rights>Springer-Verlag 2008</rights><rights>2009 INIST-CNRS</rights><rights>Springer-Verlag 2009</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c430t-448a0446b12bbd82a735e73ec1166ab1e0024c1ea8978f440693d92e281c2b9b3</citedby><cites>FETCH-LOGICAL-c430t-448a0446b12bbd82a735e73ec1166ab1e0024c1ea8978f440693d92e281c2b9b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00420-008-0386-1$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00420-008-0386-1$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>315,781,785,27928,27929,41492,42561,51323</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21647222$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19020892$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Taeger, Dirk</creatorcontrib><creatorcontrib>Johnen, Georg</creatorcontrib><creatorcontrib>Wiethege, Thorsten</creatorcontrib><creatorcontrib>Tapio, Soile</creatorcontrib><creatorcontrib>Möhner, Matthias</creatorcontrib><creatorcontrib>Wesch, Horst</creatorcontrib><creatorcontrib>Tannapfel, Andrea</creatorcontrib><creatorcontrib>Müller, Klaus-Michael</creatorcontrib><creatorcontrib>Brüning, Thomas</creatorcontrib><creatorcontrib>Pesch, Beate</creatorcontrib><title>Major histopathological patterns of lung cancer related to arsenic exposure in German uranium miners</title><title>International archives of occupational and environmental health</title><addtitle>Int Arch Occup Environ Health</addtitle><addtitle>Int Arch Occup Environ Health</addtitle><description>Objective
The mechanisms of action of arsenic in the development of lung cancer are still not yet elucidated. Considering the relationship between arsenic and squamous cell carcinomas of the skin, we hypothesized that arsenic exposure may be more closely associated with squamous cell carcinoma of the lung.
Methods
A comprehensive histopathological database and a detailed job-exposure matrix developed for former German uranium miners with exposure to arsenic, radon, and quartz were analyzed to quantitatively assess the effect of arsenic regarding cell type of lung cancer. The distributions of major lung cancer cell types in 1,786 German uranium miners were associated with levels of arsenic exposure under control for the other lung carcinogens. To evaluate the arsenic effects in association with a frequent occupational lung disease in miners stratification by silicosis was performed.
Results
There was an arsenic-related increase of the proportion of squamous cell carcinoma of the lung but restricted to miners without silicosis. The increase was found at all levels of co-exposure to radon and quartz dust. In miners with silicosis, the proportion of adenocarcinoma increased with rising arsenic exposure. Arsenic exposure was associated with non-small cell lung cancer. Silicosis turned out as major determinant of the cell type related with arsenic.
Conclusion
These results indicate a cell type characteristic effect of arsenic in the development of lung cancer.</description><subject>Adenocarcinoma - chemically induced</subject><subject>Adenocarcinoma - epidemiology</subject><subject>Adenocarcinoma - pathology</subject><subject>Aged</subject><subject>Air Pollutants - adverse effects</subject><subject>Arsenic</subject><subject>Arsenicals - adverse effects</subject><subject>Biological and medical sciences</subject><subject>Carcinoma, Non-Small-Cell Lung - chemically induced</subject><subject>Carcinoma, Non-Small-Cell Lung - epidemiology</subject><subject>Carcinoma, Non-Small-Cell Lung - pathology</subject><subject>Carcinoma, Squamous Cell - chemically induced</subject><subject>Carcinoma, Squamous Cell - epidemiology</subject><subject>Carcinoma, Squamous Cell - pathology</subject><subject>Chemical and industrial products toxicology. Toxic occupational diseases</subject><subject>Dust</subject><subject>Earth and Environmental Science</subject><subject>Environment</subject><subject>Environmental Health</subject><subject>Germany - epidemiology</subject><subject>Humans</subject><subject>Inorganic dusts (pneumoconiosises) and organic dusts (byssinosis etc.)</subject><subject>Lung cancer</subject><subject>Lung Neoplasms - chemically induced</subject><subject>Lung Neoplasms - epidemiology</subject><subject>Lung Neoplasms - pathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Metals and various inorganic compounds</subject><subject>Middle Aged</subject><subject>Mining</subject><subject>Mining industry</subject><subject>Occupational diseases</subject><subject>Occupational Diseases - chemically induced</subject><subject>Occupational Diseases - epidemiology</subject><subject>Occupational Diseases - pathology</subject><subject>Occupational exposure</subject><subject>Occupational hazards</subject><subject>Occupational Medicine/Industrial Medicine</subject><subject>Original Article</subject><subject>Pneumology</subject><subject>Quartz</subject><subject>Quartz - adverse effects</subject><subject>Radon</subject><subject>Radon - adverse effects</subject><subject>Rehabilitation</subject><subject>Silicosis</subject><subject>Silicosis - epidemiology</subject><subject>Silicosis - etiology</subject><subject>Silicosis - pathology</subject><subject>Toxicology</subject><subject>Tumors of the respiratory system and mediastinum</subject><subject>Uranium</subject><issn>0340-0131</issn><issn>1432-1246</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kFFrFDEQx4Mo9lr9AL5IEOrb1plJmt19lGJboeKLPodsdva6x25yJrug37457rAg-DQM85uZPz8h3iFcIUD9KQNoggqgqUA1psIXYoNaUYWkzUuxAaXLFBWeifOcdwBYm1q9FmfYAkHT0kb039wuJvk45iXu3fIYp7gdvZtkaRZOIcs4yGkNW-ld8Jxk4skt3MslSpcyh9FL_r2PeU0sxyDvOM0uyDW5MK6znMfAKb8RrwY3ZX57qhfi5-2XHzf31cP3u683nx8qrxUsldaNA61Nh9R1fUOuVtdcK_aIxrgOGYC0R3ZNWzeD1mBa1bfE1KCnru3Uhfh4vLtP8dfKebHzmD1Pkwsc12wJyeA1mQJ--AfcxTWFks0SkAHV6rpAeIR8ijknHuw-jbNLfyyCPfi3R_-2-LcH_xbLzvvT4bWbuX_eOAkvwOUJcLloHoonP-a_HKHRNdGBoyOXyyhsOT0n_P_3J-y0nM0</recordid><startdate>20090701</startdate><enddate>20090701</enddate><creator>Taeger, Dirk</creator><creator>Johnen, Georg</creator><creator>Wiethege, Thorsten</creator><creator>Tapio, Soile</creator><creator>Möhner, Matthias</creator><creator>Wesch, Horst</creator><creator>Tannapfel, Andrea</creator><creator>Müller, Klaus-Michael</creator><creator>Brüning, Thomas</creator><creator>Pesch, Beate</creator><general>Springer-Verlag</general><general>Springer</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T2</scope><scope>7T5</scope><scope>7TM</scope><scope>7U7</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>PATMY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PYCSY</scope><scope>Q9U</scope><scope>7U2</scope><scope>7UA</scope></search><sort><creationdate>20090701</creationdate><title>Major histopathological patterns of lung cancer related to arsenic exposure in German uranium miners</title><author>Taeger, Dirk ; Johnen, Georg ; Wiethege, Thorsten ; Tapio, Soile ; Möhner, Matthias ; Wesch, Horst ; Tannapfel, Andrea ; Müller, Klaus-Michael ; Brüning, Thomas ; Pesch, Beate</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c430t-448a0446b12bbd82a735e73ec1166ab1e0024c1ea8978f440693d92e281c2b9b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adenocarcinoma - chemically induced</topic><topic>Adenocarcinoma - epidemiology</topic><topic>Adenocarcinoma - pathology</topic><topic>Aged</topic><topic>Air Pollutants - adverse effects</topic><topic>Arsenic</topic><topic>Arsenicals - adverse effects</topic><topic>Biological and medical sciences</topic><topic>Carcinoma, Non-Small-Cell Lung - chemically induced</topic><topic>Carcinoma, Non-Small-Cell Lung - epidemiology</topic><topic>Carcinoma, Non-Small-Cell Lung - pathology</topic><topic>Carcinoma, Squamous Cell - chemically induced</topic><topic>Carcinoma, Squamous Cell - epidemiology</topic><topic>Carcinoma, Squamous Cell - pathology</topic><topic>Chemical and industrial products toxicology. Toxic occupational diseases</topic><topic>Dust</topic><topic>Earth and Environmental Science</topic><topic>Environment</topic><topic>Environmental Health</topic><topic>Germany - epidemiology</topic><topic>Humans</topic><topic>Inorganic dusts (pneumoconiosises) and organic dusts (byssinosis etc.)</topic><topic>Lung cancer</topic><topic>Lung Neoplasms - chemically induced</topic><topic>Lung Neoplasms - epidemiology</topic><topic>Lung Neoplasms - pathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Metals and various inorganic compounds</topic><topic>Middle Aged</topic><topic>Mining</topic><topic>Mining industry</topic><topic>Occupational diseases</topic><topic>Occupational Diseases - chemically induced</topic><topic>Occupational Diseases - epidemiology</topic><topic>Occupational Diseases - pathology</topic><topic>Occupational exposure</topic><topic>Occupational hazards</topic><topic>Occupational Medicine/Industrial Medicine</topic><topic>Original Article</topic><topic>Pneumology</topic><topic>Quartz</topic><topic>Quartz - adverse effects</topic><topic>Radon</topic><topic>Radon - adverse effects</topic><topic>Rehabilitation</topic><topic>Silicosis</topic><topic>Silicosis - epidemiology</topic><topic>Silicosis - etiology</topic><topic>Silicosis - pathology</topic><topic>Toxicology</topic><topic>Tumors of the respiratory system and mediastinum</topic><topic>Uranium</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Taeger, Dirk</creatorcontrib><creatorcontrib>Johnen, Georg</creatorcontrib><creatorcontrib>Wiethege, Thorsten</creatorcontrib><creatorcontrib>Tapio, Soile</creatorcontrib><creatorcontrib>Möhner, Matthias</creatorcontrib><creatorcontrib>Wesch, Horst</creatorcontrib><creatorcontrib>Tannapfel, Andrea</creatorcontrib><creatorcontrib>Müller, Klaus-Michael</creatorcontrib><creatorcontrib>Brüning, Thomas</creatorcontrib><creatorcontrib>Pesch, Beate</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Proquest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Environmental Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Environmental Science Collection</collection><collection>ProQuest Central Basic</collection><collection>Safety Science and Risk</collection><collection>Water Resources Abstracts</collection><jtitle>International archives of occupational and environmental health</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Taeger, Dirk</au><au>Johnen, Georg</au><au>Wiethege, Thorsten</au><au>Tapio, Soile</au><au>Möhner, Matthias</au><au>Wesch, Horst</au><au>Tannapfel, Andrea</au><au>Müller, Klaus-Michael</au><au>Brüning, Thomas</au><au>Pesch, Beate</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Major histopathological patterns of lung cancer related to arsenic exposure in German uranium miners</atitle><jtitle>International archives of occupational and environmental health</jtitle><stitle>Int Arch Occup Environ Health</stitle><addtitle>Int Arch Occup Environ Health</addtitle><date>2009-07-01</date><risdate>2009</risdate><volume>82</volume><issue>7</issue><spage>867</spage><epage>875</epage><pages>867-875</pages><issn>0340-0131</issn><eissn>1432-1246</eissn><coden>IAEHDW</coden><abstract>Objective
The mechanisms of action of arsenic in the development of lung cancer are still not yet elucidated. Considering the relationship between arsenic and squamous cell carcinomas of the skin, we hypothesized that arsenic exposure may be more closely associated with squamous cell carcinoma of the lung.
Methods
A comprehensive histopathological database and a detailed job-exposure matrix developed for former German uranium miners with exposure to arsenic, radon, and quartz were analyzed to quantitatively assess the effect of arsenic regarding cell type of lung cancer. The distributions of major lung cancer cell types in 1,786 German uranium miners were associated with levels of arsenic exposure under control for the other lung carcinogens. To evaluate the arsenic effects in association with a frequent occupational lung disease in miners stratification by silicosis was performed.
Results
There was an arsenic-related increase of the proportion of squamous cell carcinoma of the lung but restricted to miners without silicosis. The increase was found at all levels of co-exposure to radon and quartz dust. In miners with silicosis, the proportion of adenocarcinoma increased with rising arsenic exposure. Arsenic exposure was associated with non-small cell lung cancer. Silicosis turned out as major determinant of the cell type related with arsenic.
Conclusion
These results indicate a cell type characteristic effect of arsenic in the development of lung cancer.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>19020892</pmid><doi>10.1007/s00420-008-0386-1</doi><tpages>9</tpages></addata></record> |
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| issn | 0340-0131 1432-1246 |
| language | eng |
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| source | MEDLINE; SpringerNature Journals |
| subjects | Adenocarcinoma - chemically induced Adenocarcinoma - epidemiology Adenocarcinoma - pathology Aged Air Pollutants - adverse effects Arsenic Arsenicals - adverse effects Biological and medical sciences Carcinoma, Non-Small-Cell Lung - chemically induced Carcinoma, Non-Small-Cell Lung - epidemiology Carcinoma, Non-Small-Cell Lung - pathology Carcinoma, Squamous Cell - chemically induced Carcinoma, Squamous Cell - epidemiology Carcinoma, Squamous Cell - pathology Chemical and industrial products toxicology. Toxic occupational diseases Dust Earth and Environmental Science Environment Environmental Health Germany - epidemiology Humans Inorganic dusts (pneumoconiosises) and organic dusts (byssinosis etc.) Lung cancer Lung Neoplasms - chemically induced Lung Neoplasms - epidemiology Lung Neoplasms - pathology Male Medical sciences Metals and various inorganic compounds Middle Aged Mining Mining industry Occupational diseases Occupational Diseases - chemically induced Occupational Diseases - epidemiology Occupational Diseases - pathology Occupational exposure Occupational hazards Occupational Medicine/Industrial Medicine Original Article Pneumology Quartz Quartz - adverse effects Radon Radon - adverse effects Rehabilitation Silicosis Silicosis - epidemiology Silicosis - etiology Silicosis - pathology Toxicology Tumors of the respiratory system and mediastinum Uranium |
| title | Major histopathological patterns of lung cancer related to arsenic exposure in German uranium miners |
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