Nosocomial transmission of the F15/LAM4/KZN genotype of Mycobacterium tuberculosis in patients on tuberculosis treatment
SETTING: King George V (KGV) Hospital has the largest tuberculosis (TB) facility in KwaZulu-Natal (KZN), the province with the highest prevalence of TB-HIV (human immunodeficiency virus) co-infection in South Africa. During the study, KGV was the only provincial referral hospital for patients with d...
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| Veröffentlicht in: | The international journal of tuberculosis and lung disease 2010-02, Vol.14 (2), p.223-230 |
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| creator | PILLAY, M STURM, A. W |
| description | SETTING: King George V (KGV) Hospital has the largest tuberculosis (TB) facility in KwaZulu-Natal (KZN), the province with the highest prevalence of TB-HIV (human immunodeficiency virus) co-infection in South Africa. During the study, KGV was the only provincial referral hospital for
patients with drug-resistant TB.OBJECTIVE: To determine the role of nosocomial transmission in patients infected with a new strain of Mycobacterium tuberculosis during treatment.DESIGN: Insertion sequence 6110-DNA fingerprinting was performed on stored isolates from patients
with culture-positive pulmonary TB for more than 6 weeks after treatment started and those who relapsed.RESULTS AND CONCLUSION: DNA fingerprints of 14 of 26 patients with differing isolates matched those of other patients. Four of them acquired a F15/LAM4/KZN genotype, while two acquired
fully susceptible Beijing strains. Three of the four F15/LAM4/KZN strains were multidrug-resistant with identical fingerprint patterns, while the fourth was fully susceptible. One of these was acquired during hospitalisation and three after discharge. Both HIV-infected and non-infected patients
are at risk of infection with the F15/LAM4/KZN strain in health care facilities and within the community. Rapid diagnostic tests, separation of TB and non-TB patients on admission and isolation of multidrug-resistant and extensively drug-resistant TB patients are essential to curb nosocomial
transmission. |
| format | Article |
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patients with drug-resistant TB.OBJECTIVE: To determine the role of nosocomial transmission in patients infected with a new strain of Mycobacterium tuberculosis during treatment.DESIGN: Insertion sequence 6110-DNA fingerprinting was performed on stored isolates from patients
with culture-positive pulmonary TB for more than 6 weeks after treatment started and those who relapsed.RESULTS AND CONCLUSION: DNA fingerprints of 14 of 26 patients with differing isolates matched those of other patients. Four of them acquired a F15/LAM4/KZN genotype, while two acquired
fully susceptible Beijing strains. Three of the four F15/LAM4/KZN strains were multidrug-resistant with identical fingerprint patterns, while the fourth was fully susceptible. One of these was acquired during hospitalisation and three after discharge. Both HIV-infected and non-infected patients
are at risk of infection with the F15/LAM4/KZN strain in health care facilities and within the community. Rapid diagnostic tests, separation of TB and non-TB patients on admission and isolation of multidrug-resistant and extensively drug-resistant TB patients are essential to curb nosocomial
transmission.</description><identifier>ISSN: 1027-3719</identifier><identifier>EISSN: 1815-7920</identifier><identifier>PMID: 20074415</identifier><language>eng</language><publisher>Paris, France: IUATLD</publisher><subject>Adult ; Antitubercular Agents - pharmacology ; Bacterial diseases ; Bacterial Typing Techniques ; Biological and medical sciences ; Cross Infection - drug therapy ; Cross Infection - microbiology ; Cross Infection - transmission ; DNA Fingerprinting ; Drug Resistance, Multiple ; F15/lam4/kzn Genotype ; Female ; General aspects ; Genotype ; HIV Infections - complications ; Human bacterial diseases ; Human immunodeficiency virus ; Human infectious diseases. Experimental studies and models ; Humans ; Infectious diseases ; Male ; Medical sciences ; Middle Aged ; Mycobacterium tuberculosis ; Mycobacterium tuberculosis - genetics ; Mycobacterium tuberculosis - isolation & purification ; Nosocomial Transmission ; Pneumology ; Reinfection ; Respiratory system : syndromes and miscellaneous diseases ; South Africa - epidemiology ; Tuberculosis ; Tuberculosis and atypical mycobacterial infections ; Tuberculosis, Multidrug-Resistant - drug therapy ; Tuberculosis, Multidrug-Resistant - microbiology ; Tuberculosis, Multidrug-Resistant - transmission ; Tuberculosis, Pulmonary - drug therapy ; Tuberculosis, Pulmonary - microbiology ; Tuberculosis, Pulmonary - transmission ; Young Adult</subject><ispartof>The international journal of tuberculosis and lung disease, 2010-02, Vol.14 (2), p.223-230</ispartof><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22355985$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20074415$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>PILLAY, M</creatorcontrib><creatorcontrib>STURM, A. W</creatorcontrib><title>Nosocomial transmission of the F15/LAM4/KZN genotype of Mycobacterium tuberculosis in patients on tuberculosis treatment</title><title>The international journal of tuberculosis and lung disease</title><addtitle>Int J Tuberc Lung Dis</addtitle><description>SETTING: King George V (KGV) Hospital has the largest tuberculosis (TB) facility in KwaZulu-Natal (KZN), the province with the highest prevalence of TB-HIV (human immunodeficiency virus) co-infection in South Africa. During the study, KGV was the only provincial referral hospital for
patients with drug-resistant TB.OBJECTIVE: To determine the role of nosocomial transmission in patients infected with a new strain of Mycobacterium tuberculosis during treatment.DESIGN: Insertion sequence 6110-DNA fingerprinting was performed on stored isolates from patients
with culture-positive pulmonary TB for more than 6 weeks after treatment started and those who relapsed.RESULTS AND CONCLUSION: DNA fingerprints of 14 of 26 patients with differing isolates matched those of other patients. Four of them acquired a F15/LAM4/KZN genotype, while two acquired
fully susceptible Beijing strains. Three of the four F15/LAM4/KZN strains were multidrug-resistant with identical fingerprint patterns, while the fourth was fully susceptible. One of these was acquired during hospitalisation and three after discharge. Both HIV-infected and non-infected patients
are at risk of infection with the F15/LAM4/KZN strain in health care facilities and within the community. Rapid diagnostic tests, separation of TB and non-TB patients on admission and isolation of multidrug-resistant and extensively drug-resistant TB patients are essential to curb nosocomial
transmission.</description><subject>Adult</subject><subject>Antitubercular Agents - pharmacology</subject><subject>Bacterial diseases</subject><subject>Bacterial Typing Techniques</subject><subject>Biological and medical sciences</subject><subject>Cross Infection - drug therapy</subject><subject>Cross Infection - microbiology</subject><subject>Cross Infection - transmission</subject><subject>DNA Fingerprinting</subject><subject>Drug Resistance, Multiple</subject><subject>F15/lam4/kzn Genotype</subject><subject>Female</subject><subject>General aspects</subject><subject>Genotype</subject><subject>HIV Infections - complications</subject><subject>Human bacterial diseases</subject><subject>Human immunodeficiency virus</subject><subject>Human infectious diseases. Experimental studies and models</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Mycobacterium tuberculosis</subject><subject>Mycobacterium tuberculosis - genetics</subject><subject>Mycobacterium tuberculosis - isolation & purification</subject><subject>Nosocomial Transmission</subject><subject>Pneumology</subject><subject>Reinfection</subject><subject>Respiratory system : syndromes and miscellaneous diseases</subject><subject>South Africa - epidemiology</subject><subject>Tuberculosis</subject><subject>Tuberculosis and atypical mycobacterial infections</subject><subject>Tuberculosis, Multidrug-Resistant - drug therapy</subject><subject>Tuberculosis, Multidrug-Resistant - microbiology</subject><subject>Tuberculosis, Multidrug-Resistant - transmission</subject><subject>Tuberculosis, Pulmonary - drug therapy</subject><subject>Tuberculosis, Pulmonary - microbiology</subject><subject>Tuberculosis, Pulmonary - transmission</subject><subject>Young Adult</subject><issn>1027-3719</issn><issn>1815-7920</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kUuPFCEUhStG4zz0Lxg26qoyXB4FtZyMjmPsGWOiGzcEqmCkU1W0PIztr5ey2xgXygJuOF8Ol3MfNKcggbeiJ_hhrTERLRXQnzRnKW0xJgAgHjcnBGPBGPDT5vtdSGEIs9cTylEvafYp-bCg4FD-YtE18IvN5S27ePf5Dt3bJeT9zq7i7X4IRg_ZRl9mlIuxcShTSD4hv6Cdzt4uOaHq9JeWo9V5rtKT5pHTU7JPj-d58-n69cerm3bz_s3bq8tN6xnucttZbtwobG_MWHsfpTPSUOmI4R2MWlji-m5gho3MATAqeTd22FnBsSPScXrevDz47mL4WmzKqv5wsNOkFxtKUoJSSSnDfSVf_JckQDogrKvgsyNYzGxHtYt-1nGvfqdagedHQKdBT67mOvj0hyOU816u3IcD55cabdZqG0pcahrKD8oXnadRrTNcR6i-AVtIfYMAloQrYBzUaJ0uU1ZZR3X_QyVYm3v1L8-Dod-uO8GAFf61gB0LTJSOeb3p6E9nG7P5</recordid><startdate>20100201</startdate><enddate>20100201</enddate><creator>PILLAY, M</creator><creator>STURM, A. W</creator><general>IUATLD</general><general>International Union against Tuberculosis and Lung Disease</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7QL</scope><scope>7U1</scope><scope>7U2</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20100201</creationdate><title>Nosocomial transmission of the F15/LAM4/KZN genotype of Mycobacterium tuberculosis in patients on tuberculosis treatment</title><author>PILLAY, M ; STURM, A. W</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i406t-6e5bfd7e9bbd117d8fb8b38f2b561da7e2f96c4b4d4f1143856d60fe750f28f53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adult</topic><topic>Antitubercular Agents - pharmacology</topic><topic>Bacterial diseases</topic><topic>Bacterial Typing Techniques</topic><topic>Biological and medical sciences</topic><topic>Cross Infection - drug therapy</topic><topic>Cross Infection - microbiology</topic><topic>Cross Infection - transmission</topic><topic>DNA Fingerprinting</topic><topic>Drug Resistance, Multiple</topic><topic>F15/lam4/kzn Genotype</topic><topic>Female</topic><topic>General aspects</topic><topic>Genotype</topic><topic>HIV Infections - complications</topic><topic>Human bacterial diseases</topic><topic>Human immunodeficiency virus</topic><topic>Human infectious diseases. Experimental studies and models</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Mycobacterium tuberculosis</topic><topic>Mycobacterium tuberculosis - genetics</topic><topic>Mycobacterium tuberculosis - isolation & purification</topic><topic>Nosocomial Transmission</topic><topic>Pneumology</topic><topic>Reinfection</topic><topic>Respiratory system : syndromes and miscellaneous diseases</topic><topic>South Africa - epidemiology</topic><topic>Tuberculosis</topic><topic>Tuberculosis and atypical mycobacterial infections</topic><topic>Tuberculosis, Multidrug-Resistant - drug therapy</topic><topic>Tuberculosis, Multidrug-Resistant - microbiology</topic><topic>Tuberculosis, Multidrug-Resistant - transmission</topic><topic>Tuberculosis, Pulmonary - drug therapy</topic><topic>Tuberculosis, Pulmonary - microbiology</topic><topic>Tuberculosis, Pulmonary - transmission</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>PILLAY, M</creatorcontrib><creatorcontrib>STURM, A. W</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Risk Abstracts</collection><collection>Safety Science and Risk</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The international journal of tuberculosis and lung disease</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>PILLAY, M</au><au>STURM, A. W</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Nosocomial transmission of the F15/LAM4/KZN genotype of Mycobacterium tuberculosis in patients on tuberculosis treatment</atitle><jtitle>The international journal of tuberculosis and lung disease</jtitle><addtitle>Int J Tuberc Lung Dis</addtitle><date>2010-02-01</date><risdate>2010</risdate><volume>14</volume><issue>2</issue><spage>223</spage><epage>230</epage><pages>223-230</pages><issn>1027-3719</issn><eissn>1815-7920</eissn><abstract>SETTING: King George V (KGV) Hospital has the largest tuberculosis (TB) facility in KwaZulu-Natal (KZN), the province with the highest prevalence of TB-HIV (human immunodeficiency virus) co-infection in South Africa. During the study, KGV was the only provincial referral hospital for
patients with drug-resistant TB.OBJECTIVE: To determine the role of nosocomial transmission in patients infected with a new strain of Mycobacterium tuberculosis during treatment.DESIGN: Insertion sequence 6110-DNA fingerprinting was performed on stored isolates from patients
with culture-positive pulmonary TB for more than 6 weeks after treatment started and those who relapsed.RESULTS AND CONCLUSION: DNA fingerprints of 14 of 26 patients with differing isolates matched those of other patients. Four of them acquired a F15/LAM4/KZN genotype, while two acquired
fully susceptible Beijing strains. Three of the four F15/LAM4/KZN strains were multidrug-resistant with identical fingerprint patterns, while the fourth was fully susceptible. One of these was acquired during hospitalisation and three after discharge. Both HIV-infected and non-infected patients
are at risk of infection with the F15/LAM4/KZN strain in health care facilities and within the community. Rapid diagnostic tests, separation of TB and non-TB patients on admission and isolation of multidrug-resistant and extensively drug-resistant TB patients are essential to curb nosocomial
transmission.</abstract><cop>Paris, France</cop><pub>IUATLD</pub><pmid>20074415</pmid><tpages>8</tpages></addata></record> |
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| subjects | Adult Antitubercular Agents - pharmacology Bacterial diseases Bacterial Typing Techniques Biological and medical sciences Cross Infection - drug therapy Cross Infection - microbiology Cross Infection - transmission DNA Fingerprinting Drug Resistance, Multiple F15/lam4/kzn Genotype Female General aspects Genotype HIV Infections - complications Human bacterial diseases Human immunodeficiency virus Human infectious diseases. Experimental studies and models Humans Infectious diseases Male Medical sciences Middle Aged Mycobacterium tuberculosis Mycobacterium tuberculosis - genetics Mycobacterium tuberculosis - isolation & purification Nosocomial Transmission Pneumology Reinfection Respiratory system : syndromes and miscellaneous diseases South Africa - epidemiology Tuberculosis Tuberculosis and atypical mycobacterial infections Tuberculosis, Multidrug-Resistant - drug therapy Tuberculosis, Multidrug-Resistant - microbiology Tuberculosis, Multidrug-Resistant - transmission Tuberculosis, Pulmonary - drug therapy Tuberculosis, Pulmonary - microbiology Tuberculosis, Pulmonary - transmission Young Adult |
| title | Nosocomial transmission of the F15/LAM4/KZN genotype of Mycobacterium tuberculosis in patients on tuberculosis treatment |
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