Structure-activity relationships of N-substituted ligands for the a7 nicotinic acetylcholine receptor

A series of a7 neuronal nicotinic acetylcholine receptor ligands were designed based on a structural combination of a potent, but non-selective ligand, epibatidine, with a selective lead structure, 2. Three series of compounds in which aryl moieties were attached via a linker to different positions...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2010-01, Vol.20 (1), p.104-107
Hauptverfasser:	Mortell, Kathleen H, Schrimpf, Michael R, Bunnelle, William H, Anderson, David J, Gronlien, Jens Halvard, Hagene, Kirsten Thorin, Gopalakrishnan, Murali
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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