The efficacy and relationship between peak concentration and toxicity profile of fixed-dose-rate gemcitabine plus carboplatin in patients with advanced non-small-cell lung cancer

To investigate the efficacy and relationship between plasma concentrations at the end of infusion (C(end of infusion)) and toxicity profile of fixed-dose-rate gemcitabine plus carboplatin in chemotherapy-naive patients with advanced non-small-cell lung cancer (NSCLC). Patients were given gemcitabine...

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Veröffentlicht in:	Cancer chemotherapy and pharmacology 2007-07, Vol.60 (2), p.211-218
Hauptverfasser:	Wang, Linrun, Wu, Xiuhua, Huang, Mingzhu, Cai, Jie, Xu, Nong, Liu, Jian
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Antimetabolites, Antineoplastic - administration & dosage Antimetabolites, Antineoplastic - adverse effects Antimetabolites, Antineoplastic - pharmacokinetics Antineoplastic agents Antineoplastic Combined Chemotherapy Protocols - adverse effects Antineoplastic Combined Chemotherapy Protocols - pharmacokinetics Biological and medical sciences Carboplatin Carboplatin - administration & dosage Carboplatin - pharmacokinetics Carcinoma, Non-Small-Cell Lung - drug therapy Carcinoma, Non-Small-Cell Lung - metabolism Carcinoma, Non-Small-Cell Lung - mortality Carcinoma, Non-Small-Cell Lung - secondary Chemotherapy Deoxycytidine - administration & dosage Deoxycytidine - adverse effects Deoxycytidine - analogs & derivatives Deoxycytidine - pharmacokinetics Dosage Female Gemcitabine High performance liquid chromatography Humans Infusions, Intravenous Ion pairs Liquid chromatography Lung cancer Lung Neoplasms - drug therapy Lung Neoplasms - metabolism Lung Neoplasms - mortality Lung Neoplasms - pathology Male Medical sciences Middle Aged Neoplasm Staging Non-small cell lung carcinoma Patients Pharmacology. Drug treatments Pneumology Population studies Reduction Small cell lung carcinoma Survival Rate Thrombocytopenia Toxicity Tumors Tumors of the respiratory system and mediastinum
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