Mitochondrial apoptosis is induced by Alkoxy phenyl-1-propanone derivatives through PP2A-mediated dephosphorylation of Bad and Foxo3A in CLL

Protein phosphatase 2 A (PP2A) is a tumour suppressor whose strong inhibition underlies the phosphorylation-dependent, anti-apoptotic mechanisms in Chronic Lymphocytic Leukemia (CLL). Inactivation of PP2A is due to the cooperative action of the phosphorylation of Y307 of its catalytic subunit by the...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Leukemia 2019-05, Vol.33 (5), p.1148-1160
Hauptverfasser:	Pagano, Mario Angelo, Tibaldi, Elena, Molino, Pierfrancesco, Frezzato, Federica, Trimarco, Valentina, Facco, Monica, Zagotto, Giuseppe, Ribaudo, Giovanni, Leanza, Luigi, Peruzzo, Roberta, Szabò, Ildikò, Visentin, Andrea, Frasson, Martina, Semenzato, Gianpietro, Trentin, Livio, Brunati, Anna Maria
Format:	Artikel
Sprache:	eng
Schlagworte:	631/45 631/67/1990/283/1895 82/29 96 96/1 96/109 96/2 96/31 Acetone AKT protein Apoptosis Apoptosis - drug effects Apoptosis - genetics B cells bcl-Associated Death Protein - metabolism BIM protein Cancer Research Care and treatment Catalysis Cell Line, Tumor Chemical compounds Chronic lymphocytic leukemia Critical Care Medicine Cytochromes c - genetics Cytochromes c - metabolism Deactivation Dephosphorylation Enzyme Activation Family Forkhead Box Protein O3 - metabolism FOXO3 protein Gene Expression Genetic aspects Hematology Humans Inactivation Intensive Internal Medicine Kinases Lead compounds Leukemia Leukemia, Lymphocytic, Chronic, B-Cell - genetics Leukemia, Lymphocytic, Chronic, B-Cell - metabolism Leukemia, Lymphocytic, Chronic, B-Cell - pathology Lymphatic leukemia Lymphocytic leukemia Lyn protein Medicine Medicine & Public Health Mitochondria Mitochondria - drug effects Mitochondria - metabolism Models, Biological Oncology Pharmacology Phosphatases Phosphorylation Protein phosphatase Protein Phosphatase 2 - metabolism Proteins Risk factors Suppressors Transcription (Genetics) Transcription activation Tumors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!