Effects of Low Level Laser Therapy on Erosive-atrophic Oral Lichen Planus
The erosive-atrophic form of oral lichen planus (OLP) is associated with severe pain and burning sensation and is often unresponsive to treatment. Topical corticosteroids are considered as a medication of first choice but they can produce adverse effects. Therefore, new therapeutic approaches are re...
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| Veröffentlicht in: | Folia Medica 2018-09, Vol.60 (3), p.417-424 |
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| creator | Mutafchieva, Maria Z Draganova-Filipova, Milena N Zagorchev, Plamen I Tomov, Georgi T |
| description | The erosive-atrophic form of oral lichen planus (OLP) is associated with severe pain and burning sensation and is often unresponsive to treatment. Topical corticosteroids are considered as a medication of first choice but they can produce adverse effects. Therefore, new therapeutic approaches are required.
The aim of this study was to investigate the effectiveness of biomodulation with diode laser in patients presenting with long-standing erosive-atrophic OLP.
Twelve patients, clinically and histologically diagnosed with OLP, participated in this study. The level of pain and the clinical scores of total 59 lesions were recorded before treatment using visual analog scale and Thongprasom sign scoring system respectively. All patients received low level laser therapy (LLLT) with diode laser (810 nm) with parameters (0.5 W, 30 s, 1.2 J/cm2) three times weekly for a month. The response rate was assessed according to the decrease in pain and sign scores. Treatment efficacy index was calculated.
There was a significant reduction in pain after LLLT (p |
| doi_str_mv | 10.2478/folmed-2018-0008 |
| format | Article |
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The aim of this study was to investigate the effectiveness of biomodulation with diode laser in patients presenting with long-standing erosive-atrophic OLP.
Twelve patients, clinically and histologically diagnosed with OLP, participated in this study. The level of pain and the clinical scores of total 59 lesions were recorded before treatment using visual analog scale and Thongprasom sign scoring system respectively. All patients received low level laser therapy (LLLT) with diode laser (810 nm) with parameters (0.5 W, 30 s, 1.2 J/cm2) three times weekly for a month. The response rate was assessed according to the decrease in pain and sign scores. Treatment efficacy index was calculated.
There was a significant reduction in pain after LLLT (p<0.0001). Improvement in clinical signs was achieved in 59.3% of the lesions. At the end of the treatment 5.1% of the lesions exhibited score 5; 6.8% - score 4, 11.9% of the lesions were scored 3 and 8.5% and 30.5% showed score 2 and score 1, respectively. Complete resolution was revealed in 37.3% of the lesions. All patients experienced some degree of improvement. Most of the cases showed moderate recovery.
The present results indicate that LLLT is an effective and harmless modality for management of erosive-atrophic OLP.</description><identifier>ISSN: 0204-8043</identifier><identifier>ISSN: 1314-2143</identifier><identifier>EISSN: 1314-2143</identifier><identifier>DOI: 10.2478/folmed-2018-0008</identifier><identifier>PMID: 30355837</identifier><language>eng</language><publisher>Bulgaria: MEDICAL UNIVERSITY- PLOVDIV</publisher><subject>Adult ; Aged ; Female ; Humans ; Inflammation ; Inhibitor drugs ; Lasers ; Lasers, Semiconductor - therapeutic use ; Lichen Planus, Oral - radiotherapy ; Light therapy ; LLLT ; Low-Level Light Therapy - methods ; Male ; Middle Aged ; OLP ; Oral diseases ; Pain ; Pain Measurement ; Signs ; Skin diseases ; Treatment Outcome ; Young Adult</subject><ispartof>Folia Medica, 2018-09, Vol.60 (3), p.417-424</ispartof><rights>Copyright MEDICAL UNIVERSITY- PLOVDIV 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4717-3b9e53e5b26664ab6e093324319fccbd266a714554a2ec28ab1ffe769b7ee0363</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,27907,27908</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30355837$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mutafchieva, Maria Z</creatorcontrib><creatorcontrib>Draganova-Filipova, Milena N</creatorcontrib><creatorcontrib>Zagorchev, Plamen I</creatorcontrib><creatorcontrib>Tomov, Georgi T</creatorcontrib><title>Effects of Low Level Laser Therapy on Erosive-atrophic Oral Lichen Planus</title><title>Folia Medica</title><addtitle>Folia Med (Plovdiv)</addtitle><description>The erosive-atrophic form of oral lichen planus (OLP) is associated with severe pain and burning sensation and is often unresponsive to treatment. Topical corticosteroids are considered as a medication of first choice but they can produce adverse effects. Therefore, new therapeutic approaches are required.
The aim of this study was to investigate the effectiveness of biomodulation with diode laser in patients presenting with long-standing erosive-atrophic OLP.
Twelve patients, clinically and histologically diagnosed with OLP, participated in this study. The level of pain and the clinical scores of total 59 lesions were recorded before treatment using visual analog scale and Thongprasom sign scoring system respectively. All patients received low level laser therapy (LLLT) with diode laser (810 nm) with parameters (0.5 W, 30 s, 1.2 J/cm2) three times weekly for a month. The response rate was assessed according to the decrease in pain and sign scores. Treatment efficacy index was calculated.
There was a significant reduction in pain after LLLT (p<0.0001). Improvement in clinical signs was achieved in 59.3% of the lesions. At the end of the treatment 5.1% of the lesions exhibited score 5; 6.8% - score 4, 11.9% of the lesions were scored 3 and 8.5% and 30.5% showed score 2 and score 1, respectively. Complete resolution was revealed in 37.3% of the lesions. All patients experienced some degree of improvement. Most of the cases showed moderate recovery.
The present results indicate that LLLT is an effective and harmless modality for management of erosive-atrophic OLP.</description><subject>Adult</subject><subject>Aged</subject><subject>Female</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Inhibitor drugs</subject><subject>Lasers</subject><subject>Lasers, Semiconductor - therapeutic use</subject><subject>Lichen Planus, Oral - radiotherapy</subject><subject>Light therapy</subject><subject>LLLT</subject><subject>Low-Level Light Therapy - methods</subject><subject>Male</subject><subject>Middle Aged</subject><subject>OLP</subject><subject>Oral diseases</subject><subject>Pain</subject><subject>Pain Measurement</subject><subject>Signs</subject><subject>Skin diseases</subject><subject>Treatment Outcome</subject><subject>Young Adult</subject><issn>0204-8043</issn><issn>1314-2143</issn><issn>1314-2143</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DOA</sourceid><recordid>eNpdkU1vEzEQhi0EoqFw54QsceGyMPbYa-eIqgCRViqHcra83jHZaBMHO1vUf4-XtBw4jTTzzDsfL2NvBXyUythPMU0HGhoJwjYAYJ-xlUChGikUPmcrkKAaCwqv2KtS9gCtBtAv2RUCam3RrNh2EyOFc-Ep8i795h3d08Q7Xyjzux1lf3rg6cg3OZXxnhp_zum0GwO_zb5iY9jRkX-f_HEur9mL6KdCbx7jNfvxZXN3863pbr9ubz53TVBGmAb7NWkk3cu2bZXvW4I1olQo1jGEfqhpb4TSWnlJQVrfi7qhade9IQJs8ZptL7pD8nt3yuPB5weX_Oj-JlL-6Xw-j2Eip2N9RgDvY7TKEvUDKiBlEJSug4aq9eGidcrp10zl7A5jCTTVgyjNxUkhNUIrDFT0_X_oPs35WC9dKIPaCmsqBRcq1IeVTPHfggLcYpm7WOYWy9xiWW159yg890vlqeHJI_wDVX6QUQ</recordid><startdate>20180901</startdate><enddate>20180901</enddate><creator>Mutafchieva, Maria Z</creator><creator>Draganova-Filipova, Milena N</creator><creator>Zagorchev, Plamen I</creator><creator>Tomov, Georgi T</creator><general>MEDICAL UNIVERSITY- PLOVDIV</general><general>Pensoft Publishers</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>4T-</scope><scope>4U-</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>BYOGL</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>DOA</scope></search><sort><creationdate>20180901</creationdate><title>Effects of Low Level Laser Therapy on Erosive-atrophic Oral Lichen Planus</title><author>Mutafchieva, Maria Z ; Draganova-Filipova, Milena N ; Zagorchev, Plamen I ; Tomov, Georgi T</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4717-3b9e53e5b26664ab6e093324319fccbd266a714554a2ec28ab1ffe769b7ee0363</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Female</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Inhibitor drugs</topic><topic>Lasers</topic><topic>Lasers, Semiconductor - therapeutic use</topic><topic>Lichen Planus, Oral - radiotherapy</topic><topic>Light therapy</topic><topic>LLLT</topic><topic>Low-Level Light Therapy - methods</topic><topic>Male</topic><topic>Middle Aged</topic><topic>OLP</topic><topic>Oral diseases</topic><topic>Pain</topic><topic>Pain Measurement</topic><topic>Signs</topic><topic>Skin diseases</topic><topic>Treatment Outcome</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mutafchieva, Maria Z</creatorcontrib><creatorcontrib>Draganova-Filipova, Milena N</creatorcontrib><creatorcontrib>Zagorchev, Plamen I</creatorcontrib><creatorcontrib>Tomov, Georgi T</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Docstoc</collection><collection>University Readers</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>East Europe, Central Europe Database</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Folia Medica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mutafchieva, Maria Z</au><au>Draganova-Filipova, Milena N</au><au>Zagorchev, Plamen I</au><au>Tomov, Georgi T</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of Low Level Laser Therapy on Erosive-atrophic Oral Lichen Planus</atitle><jtitle>Folia Medica</jtitle><addtitle>Folia Med (Plovdiv)</addtitle><date>2018-09-01</date><risdate>2018</risdate><volume>60</volume><issue>3</issue><spage>417</spage><epage>424</epage><pages>417-424</pages><issn>0204-8043</issn><issn>1314-2143</issn><eissn>1314-2143</eissn><abstract>The erosive-atrophic form of oral lichen planus (OLP) is associated with severe pain and burning sensation and is often unresponsive to treatment. Topical corticosteroids are considered as a medication of first choice but they can produce adverse effects. Therefore, new therapeutic approaches are required.
The aim of this study was to investigate the effectiveness of biomodulation with diode laser in patients presenting with long-standing erosive-atrophic OLP.
Twelve patients, clinically and histologically diagnosed with OLP, participated in this study. The level of pain and the clinical scores of total 59 lesions were recorded before treatment using visual analog scale and Thongprasom sign scoring system respectively. All patients received low level laser therapy (LLLT) with diode laser (810 nm) with parameters (0.5 W, 30 s, 1.2 J/cm2) three times weekly for a month. The response rate was assessed according to the decrease in pain and sign scores. Treatment efficacy index was calculated.
There was a significant reduction in pain after LLLT (p<0.0001). Improvement in clinical signs was achieved in 59.3% of the lesions. At the end of the treatment 5.1% of the lesions exhibited score 5; 6.8% - score 4, 11.9% of the lesions were scored 3 and 8.5% and 30.5% showed score 2 and score 1, respectively. Complete resolution was revealed in 37.3% of the lesions. All patients experienced some degree of improvement. Most of the cases showed moderate recovery.
The present results indicate that LLLT is an effective and harmless modality for management of erosive-atrophic OLP.</abstract><cop>Bulgaria</cop><pub>MEDICAL UNIVERSITY- PLOVDIV</pub><pmid>30355837</pmid><doi>10.2478/folmed-2018-0008</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Folia Medica, 2018-09, Vol.60 (3), p.417-424 |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Adult Aged Female Humans Inflammation Inhibitor drugs Lasers Lasers, Semiconductor - therapeutic use Lichen Planus, Oral - radiotherapy Light therapy LLLT Low-Level Light Therapy - methods Male Middle Aged OLP Oral diseases Pain Pain Measurement Signs Skin diseases Treatment Outcome Young Adult |
| title | Effects of Low Level Laser Therapy on Erosive-atrophic Oral Lichen Planus |
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