Blood-Stage Plasmodium Berghei ANKA Infection Promotes Hepatic Fibrosis by Enhancing Hedgehog Signaling in Mice

Background/Aims: Malaria is the most deadly parasitic infection in the world, resulting in damage to various organs, including the liver, of the infected organism; however, the mechanism causing this damage in the liver remains unclear. Liver fibrosis, a major characteristic of liver diseases, occur...

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Veröffentlicht in:	Cellular physiology and biochemistry 2018-01, Vol.50 (4), p.1414-1428
Hauptverfasser:	Kim, Jieun, Wang, Sihyung, Lee, Chanbin, Sung, Sumi, Shin, Yongbo, Song, Kyoung Seob, Cha, Hee-Jae, Ock, Meesun, Jung, Youngmi
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins - metabolism Adaptor Proteins, Signal Transducing - metabolism Anilides - therapeutic use Animals Cell Cycle Proteins Chemokines, C - metabolism Collagen Type I - metabolism Fibrosis Hedgehog Hedgehog Proteins - antagonists & inhibitors Hedgehog Proteins - metabolism Hepatic Stellate Cells - cytology Hepatic Stellate Cells - metabolism Hepatology Hypoxia Infections Inflammation Kinases Laboratory animals Ligands Liver Liver - metabolism Liver - parasitology Liver cirrhosis Liver Cirrhosis - drug therapy Liver Cirrhosis - metabolism Liver Cirrhosis - pathology Liver diseases Malaria Malaria - parasitology Malaria - pathology Malaria - veterinary Male Mice Mice, Inbred C57BL Mortality Original Paper Oxidative stress Phosphoproteins - metabolism Plasmodium berghei - growth & development Plasmodium berghei - pathogenicity Plasmodium berghei ANKA Pyridines - therapeutic use Signal Transduction - physiology Thymosin - metabolism Transforming Growth Factor beta - metabolism Up-Regulation Vimentin - metabolism
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