Multifunctional approaches utilizing polymeric micelles to circumvent multidrug resistant tumors

[Display omitted] •Polymeric micelles (PMs) offer several advantages in targeting anticancer drugs.•Active targeting in PMs utilizes receptor mediated endocytosis.•The reduction sensitive PMs release the drug into cytoplasm.•pH responsive PMs exploit low pH environment of cancer cell due to glycolys...

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Veröffentlicht in:	Colloids and surfaces, B, Biointerfaces B, Biointerfaces, 2019-01, Vol.173, p.581-590
Hauptverfasser:	Kesharwani, Siddharth S., Kaur, Shamandeep, Tummala, Hemachand, Sangamwar, Abhay T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Active targeting Antineoplastic Agents - pharmacokinetics Antineoplastic Agents - pharmacology Cancer Colloids Combined Modality Therapy - methods Drug Delivery Systems - instrumentation Drug Delivery Systems - methods Drug resistance Drug Resistance, Multiple - drug effects Drug Resistance, Neoplasm - drug effects Humans Hydrogen-Ion Concentration Hydrophobic and Hydrophilic Interactions Micelles Nanotechnology Nanotechnology - instrumentation Nanotechnology - methods Neoplasms - pathology Neoplasms - therapy Polymeric micelles Polymers - chemical synthesis Polymers - metabolism Solubility Stimuli-responsive
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