13C NMR Signal Enhancement Using Parahydrogen-Induced Polarization Mediated by a Cobalt Hydrogenation Catalyst
The use of a cobalt-based catalyst for the generation of hyperpolarized 13C NMR resonances by parahydrogenation of ethyl acrylate is presented herein. Comparisons of the carboxylate 13C NMR signal enhancement factor of ethyl propionate between using (MesCCC)Co-py and a commonly utilized cationic di...
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Veröffentlicht in: | Journal of the American Chemical Society 2018-11, Vol.140 (44), p.14844-14850 |
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creator | Tokmic, Kenan Greer, Rianna B Zhu, Lingyang Fout, Alison R |
description | The use of a cobalt-based catalyst for the generation of hyperpolarized 13C NMR resonances by parahydrogenation of ethyl acrylate is presented herein. Comparisons of the carboxylate 13C NMR signal enhancement factor of ethyl propionate between using (MesCCC)Co-py and a commonly utilized cationic diphosphine rhodium complex demonstrates that the cobalt system is a viable PHIP catalyst alternative. Furthermore, the operative hydrogenation mechanism of the cobalt system was examined by using 1H, 13C, and parahydrogen-induced polarization NMR spectroscopies to elucidate reaction intermediates affiliated with the observed 1H and 13C NMR signal enhancements in ethyl propionate. |
doi_str_mv | 10.1021/jacs.8b08614 |
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Furthermore, the operative hydrogenation mechanism of the cobalt system was examined by using 1H, 13C, and parahydrogen-induced polarization NMR spectroscopies to elucidate reaction intermediates affiliated with the observed 1H and 13C NMR signal enhancements in ethyl propionate.</description><issn>0002-7863</issn><issn>1520-5126</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNpF0LFOwzAQBmALgUQpbDyAR5YUnx07yYiiQiu1UEGZo0tybVOlNsTOUJ6eoFZiOt3p_2_4GLsHMQEh4XGPlZ-kpUgNxBdsBFqKSIM0l2wkhJBRkhp1zW683w9rLFMYMQsq56_Ld_7RbC22fGp3aCs6kA380zd2y1fY4e5Yd25LNprbuq-o5ivXYtf8YGic5UuqGwzDtTxy5LkrsQ18dq6cIjkGbI8-3LKrDbae7s5zzNbP03U-ixZvL_P8aRGhMRBlqhLSJBIIq0RAilmpUSlIKEWSoGiz0SaWKESmdCJUZrIKE9KKUCCBVGP2cHr71bnvnnwoDo2vqG3Rkut9IUFqmWWxgv_oYFfsXd8NCr4AUfyJFn-ixVlU_QIWDmj_</recordid><startdate>20181107</startdate><enddate>20181107</enddate><creator>Tokmic, Kenan</creator><creator>Greer, Rianna B</creator><creator>Zhu, Lingyang</creator><creator>Fout, Alison R</creator><general>American Chemical Society</general><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-4669-5835</orcidid></search><sort><creationdate>20181107</creationdate><title>13C NMR Signal Enhancement Using Parahydrogen-Induced Polarization Mediated by a Cobalt Hydrogenation Catalyst</title><author>Tokmic, Kenan ; Greer, Rianna B ; Zhu, Lingyang ; Fout, Alison R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a661-93c026721eac7018a9b5a3317e8ae213eff5642a00935703969ca7e53ea0ae123</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tokmic, Kenan</creatorcontrib><creatorcontrib>Greer, Rianna B</creatorcontrib><creatorcontrib>Zhu, Lingyang</creatorcontrib><creatorcontrib>Fout, Alison R</creatorcontrib><collection>MEDLINE - Academic</collection><jtitle>Journal of the American Chemical Society</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tokmic, Kenan</au><au>Greer, Rianna B</au><au>Zhu, Lingyang</au><au>Fout, Alison R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>13C NMR Signal Enhancement Using Parahydrogen-Induced Polarization Mediated by a Cobalt Hydrogenation Catalyst</atitle><jtitle>Journal of the American Chemical Society</jtitle><addtitle>J. Am. Chem. Soc</addtitle><date>2018-11-07</date><risdate>2018</risdate><volume>140</volume><issue>44</issue><spage>14844</spage><epage>14850</epage><pages>14844-14850</pages><issn>0002-7863</issn><eissn>1520-5126</eissn><abstract>The use of a cobalt-based catalyst for the generation of hyperpolarized 13C NMR resonances by parahydrogenation of ethyl acrylate is presented herein. Comparisons of the carboxylate 13C NMR signal enhancement factor of ethyl propionate between using (MesCCC)Co-py and a commonly utilized cationic diphosphine rhodium complex demonstrates that the cobalt system is a viable PHIP catalyst alternative. Furthermore, the operative hydrogenation mechanism of the cobalt system was examined by using 1H, 13C, and parahydrogen-induced polarization NMR spectroscopies to elucidate reaction intermediates affiliated with the observed 1H and 13C NMR signal enhancements in ethyl propionate.</abstract><pub>American Chemical Society</pub><doi>10.1021/jacs.8b08614</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-4669-5835</orcidid></addata></record> |
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title | 13C NMR Signal Enhancement Using Parahydrogen-Induced Polarization Mediated by a Cobalt Hydrogenation Catalyst |
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