Discovery of Novel Flavonoid Dimers To Reverse Multidrug Resistance Protein 1 (MRP1, ABCC1) Mediated Drug Resistance in Cancers Using a High Throughput Platform with “Click Chemistry”

A 300-member flavonoid dimer library of multidrug resistance-associated protein 1 (MRP1, ABCC1) modulators was rapidly assembled using “click chemistry”. Subsequent high-throughput screening has led to the discovery of highly potent (EC50 ranging from 53 to 298 nM) and safe (selective indexes rangin...

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Veröffentlicht in:	Journal of medicinal chemistry 2018-11, Vol.61 (22), p.9931-9951
Hauptverfasser:	Wong, Iris L. K, Zhu, Xuezhen, Chan, Kin-Fai, Law, Man Chun, Lo, Aya M. Y, Hu, Xuesen, Chow, Larry M. C, Chan, Tak Hang
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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