AMPA receptors and seizures mediate hippocampal radial glia‐like stem cell proliferation

Neurogenesis is sustained throughout life in the mammalian brain, supporting hippocampus‐dependent learning and memory. Its permanent alteration by status epilepticus (SE) is associated with learning and cognitive impairments. The mechanisms underlying the initiation of altered neurogenesis after SE...

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Veröffentlicht in:	Glia 2018-11, Vol.66 (11), p.2397-2413
Hauptverfasser:	Shtaya, Anan, Sadek, Ahmed‐Ramadan, Zaben, Malik, Seifert, Gerald, Pringle, Ashley, Steinhäuser, Christian, Gray, William Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute effects AMPARs Animals Animals, Newborn Benzodiazepines - pharmacology Brain Cell activation Cell cycle Cell Death - genetics Cell proliferation Cell Proliferation - physiology Cell survival Cells, Cultured Cognitive ability Cycle time Epilepsy Excitatory Amino Acid Agonists - pharmacology Excitatory Amino Acid Antagonists - pharmacology Glial fibrillary acidic protein Hippocampus Hippocampus - cytology Kainate Kainic Acid - pharmacology Ki-67 Antigen - metabolism Learning Male Membrane Potentials - drug effects Membrane Potentials - genetics Memory Nerve Tissue Proteins - metabolism Neural stem cells Neurogenesis Neuroglia - pathology Neuronal-glial interactions Pharmacology Precursors Progeny Proteins Quinoxalines - pharmacology Radial glial cells radial glia‐like rat Rats Rats, Wistar Receptors Receptors, AMPA - genetics Receptors, AMPA - metabolism Seizures Seizures - pathology Stem cells Stem Cells - pathology Survival α-Amino-3-hydroxy-5-methyl-4-isoxazole propionic acid α-Amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors
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